Abstract: A compound according to Formula (Ia), wherein Cy, L1, G, and R1 are as described herein. The present invention relates to novel compounds according to Formula (I) that antagonize GPR84, a G-protein-coupled receptor that is involved in inflammatory conditions, and methods for the production of these novel compounds, pharmaceutical compositions comprising these compounds, and methods for the prevention and/or treatment of inflammatory conditions (for example inflammatory bowel diseases (IBD), rheumatoid arthritis, vasculitis), lung diseases (e.g. chronic obstructive pulmonary disease (COPD) and lung interstitial diseases (e.g. idiopathic pulmonary fibrosis (IPF))), neuroinflammatory conditions, infectious diseases, autoimmune diseases, endocrine and/or metabolic diseases, and/or diseases involving impairment of immune cell functions by administering a compound of the invention.

Abstract: A compound according to Formula Ia: wherein L1, G, and R1 are as described herein. The present invention relates to novel compounds according to Formula I that antagonize GPR84, a G-protein-coupled receptor that is involved in inflammatory conditions, and methods for the production of these novel compounds, pharmaceutical compositions comprising these compounds, and methods for the prevention and/or treatment of inflammatory conditions (for example inflammatory bowel diseases (IBD), rheumatoid arthritis, vasculitis, lung diseases (e.g. chronic obstructive pulmonary disease (COPD) and lung interstitial diseases (e.g. idiopathic pulmonary fibrosis (IPF))), neuroinflammatory conditions, infectious diseases, autoimmune diseases, endocrine and/or metabolic diseases, and/or diseases involving impairment of immune cell functions by administering a compound of the invention.

Abstract: A compound according to Formula Ia: wherein L1, G, and R1 are as described herein. The present invention relates to novel compounds according to Formula I that antagonize GPR84, a G-protein-coupled receptor that is involved in inflammatory conditions, and methods for the production of these novel compounds, pharmaceutical compositions comprising these compounds, and methods for the prevention and/or treatment of inflammatory conditions (for example inflammatory bowel diseases (IBD), rheumatoid arthritis, vasculitis, lung diseases (e.g. chronic obstructive pulmonary disease (COPD) and lung interstitial diseases (e.g. idiopathic pulmonary fibrosis (IPF))), neuroinflammatory conditions, infectious diseases, autoimmune diseases, endocrine and/or metabolic diseases, and/or diseases involving impairment of immune cell functions by administering a compound of the invention.

Abstract: A compound according to Formula Ia: wherein L1, G, and R1 are as described herein. The present invention relates to novel compounds according to Formula I that antagonize GPR84, a G-protein-coupled receptor that is involved in inflammatory conditions, and methods for the production of these novel compounds, pharmaceutical compositions comprising these compounds, and methods for the prevention and/or treatment of inflammatory conditions (for example inflammatory bowel diseases (IBD), rheumatoid arthritis, vasculitis, lung diseases (e.g. chronic obstructive pulmonary disease (COPD) and lung interstitial diseases (e.g. idiopathic pulmonary fibrosis (IPF))), neuroinflammatory conditions, infectious diseases, autoimmune diseases, endocrine and/or metabolic diseases, and/or diseases involving impairment of immune cell functions by administering a compound of the invention.

Abstract: A method for forming vertical stacks of documents and then conveying the stacks serially along a conveyor to further processing stations. The stacks are rapidly ejected onto a conveyor which is driven at a relatively slow delivery speed, and to avoid longitudinal shingling of the stacks caused by their rapid ejection onto the conveyor, and to correct any lateral misalignment of each stack, there is provided a pair of rotatably mounted resilient guide rolls along respective opposite sides of the conveyor for rotation about vertical axes. The rolls are spaced apart a distance such that the rolls resiliently engage the opposite sides of the stacks as they pass therebetween. Also, the guide rolls are rotated at an initial peripheral speed which closely approximates the speed of the advancing stacks when the stacks engage the two guide rolls, which serves to square the stacks.

Abstract: A method for forming vertical stacks of documents and then conveying the stacks serially along a conveyor to further processing stations. The stacks are rapidly ejected onto a conveyor which is driven at a relatively slow delivery speed, and to avoid longitudinal shingling of the stacks caused by their rapid ejection onto the conveyor, and to correct any lateral misalignment of each stack, there is provided a pair of rotatably mounted resilient guide rolls along respective opposite sides of the conveyor for rotation about vertical axes. The rolls are spaced apart a distance such that the rolls resiliently engage the opposite sides of the stacks as they pass therebetween. Also, the guide rolls are rotated at an initial peripheral speed which closely approximates the speed of the advancing stacks when the stacks engage the two guide rolls, which serves to square the stacks.

Abstract: An apparatus for forming vertical stacks of documents and then conveying the stacks serially along a conveyor to further processing stations. The stacks are rapidly ejected onto a conveyor which is driven at a relatively slow delivery speed, and to avoid longitudinal shingling of the stacks caused by their rapid ejection onto the conveyor, and to correct any lateral misalignment of each stack, there is provided a pair of rotatably mounted resilient guide rolls along respective opposite sides of the conveyor for rotation about vertical axes. The rolls are spaced apart a distance such that the rolls resiliently engage the opposite sides of the stacks as they pass therebetween. Also, the guide rolls are rotated at an initial peripheral speed which closely approximates the speed of the advancing stacks when the stacks engage the two guide rolls, which serves to square the stacks.

Abstract: An apparatus for forming and conveying stacks of documents includes a stacking machine positioned above a conveying machine. The stacking machine includes a compartment for receiving documents to be stacked. Two rotor assemblies are rotated in opposite directions to repeatedly define a closed configuration in which the documents are stacked within the compartment, and an open configuration in which a stack is dropped from the rotor assemblies to the conveying machine. The conveying machine includes a support surface upon which the stacks are sequentially dropped, and a pusher assembly for moving the stacks along the support surface. The pusher assembly includes two chain assemblies that travel around similar yet offset travel paths and carry multiple pusher bars. Each pusher bar is pivotally connected to both chain assemblies such that the pusher bars define a continuous pusher travel path, and the pusher bars remain generally upright around the entire pusher travel path.

Abstract: A gate for rejecting from a gathering conveyor folded printed products which are found to be defective. The gate includes several mating pairs of ejector rolls positioned to form a nip above the gathering conveyor, and an air ejection system for lifting a defective product into the nip so that the ejector rolls engage the lifted product and convey it to a reject receptacle.