Patents by Inventor John Robert Proudfoot

John Robert Proudfoot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
    Patent number: 7256300
    Abstract: A process for stereoselective synthesis of a compound of Formula (X) or Formula (X?) wherein R1, R2, and R3 are as defined herein, the process comprising: (a) reacting the starting material of formula A with a chiral sulfoxide anion source in a suitable solvent to prepare a compound of formula C or C?; (b) reducing the sulfoxide of formula C or C? in a suitable solvent to obtain the compound of formula D or D?; and (c) cyclizing the compound of formula D or D? in a suitable solvent to form the epoxide compound of Formula (X) or Formula (X?), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: August 14, 2007
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Thomas Wai-Ho Lee, John Robert Proudfoot
  • Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
    Patent number: 7186864
    Abstract: A compound of Formula (IA) or Formula (IB) wherein R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: March 6, 2007
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Thomas Martin Kirrane, Jr., Daniel Kuzmich, John Robert Proudfoot, David Thomson
  • Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
    Patent number: 7074806
    Abstract: A compound of Formula (IA) or Formula (IB) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, or a tautomer prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: July 11, 2006
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Thomas Martin Kirrane, Jr., Daniel Kuzmich, John Robert Proudfoot, Hossein Razavi, David Thomson
  • Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
    Publication number: 20040224992
    Abstract: Compounds of Formula (I) 1
    Type: Application
    Filed: February 24, 2004
    Publication date: November 11, 2004
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Charles Lawrence Cywin, Tina Marie Morwick, John Robert Proudfoot, David Thomson
  • Fluorescence polarization assay
    Patent number: 6794158
    Abstract: This invention is directed to a fluorescence polarization assay useful in the detection and evaluation of soluble epoxide hydrolase (sEH) inhibitors. This invention also relates to novel fluorescent probes used in the fluorescence polarization assay, and methods of manufacturing such fluorescent probes. This fluorescent probe of the invention is a compound having the following formula (I): X-spacer-R1-Y  (I) wherein X is the radical of compound that binds to the active site of soluble epoxide hydrolase, Y is a fluorescent label, and “spacer” and R1 are as defined herein.
    Type: Grant
    Filed: March 28, 2002
    Date of Patent: September 21, 2004
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Richard Harold Ingraham, Mario G. Cardozo, Christine Anne Grygon, Rachel Rebecca Kroe, John Robert Proudfoot
  • Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
    Publication number: 20040162321
    Abstract: Compounds of Formula (I) 1
    Type: Application
    Filed: December 18, 2003
    Publication date: August 19, 2004
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Daniel Kuzmich, Thomas Wai-Ho Lee, John Robert Proudfoot, John Robinson Regan, David S. Thomson, Abdelhakim Hammach, Mark Stephen Ralph, Renee Zindell
  • Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
    Publication number: 20040029932
    Abstract: Compounds of Formula (IA) and Formula (IB) 1
    Type: Application
    Filed: March 21, 2003
    Publication date: February 12, 2004
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Younes Bekkali, Mario G. Cardozo, Christian Hanke Justus Joachim Harcken, Thomas M. Kirrane, Daniel Kuzmich, John Robert Proudfoot, Hossein Razavi, Hidenori Takahashi, David S. Thomson, Ji Wang, Renee Zindell
  • Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
    Publication number: 20040023999
    Abstract: Compounds of Formula (IA) and Formula (IB) 1
    Type: Application
    Filed: March 21, 2003
    Publication date: February 5, 2004
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Younes Bekkali, Rajashehar Betageri, Mario G. Cardozo, Thomas A. Gilmore, Christian Hanke Justus Joachim Harcken, Thomas M. Kirrane, Daniel Kuzmich, John Robert Proudfoot, Doris Riether, Hidenori Takahashi, David S. Thomson, Ji Wang, Renee Zindell, Hossein Razavi
  • Compounds useful as anti-inflammatory agents
    Publication number: 20040019038
    Abstract: Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.
    Type: Application
    Filed: July 21, 2003
    Publication date: January 29, 2004
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Pier F. Cirillo, Steffen Breitfelder, Usha R. Patel, John Robert Proudfoot, Alan D. Swinamer, Hidenori Takahashi, Thomas A. Gilmore, Rajiv Sharma
  • Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
    Publication number: 20040010148
    Abstract: A compound of Formula (IA) or Formula (IB) 1
    Type: Application
    Filed: May 28, 2003
    Publication date: January 15, 2004
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Thomas Martin Kirrane, Daniel Kuzmich, John Robert Proudfoot, Hossein Razavi, David Thomson
  • Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
    Publication number: 20040010020
    Abstract: A compound of Formula (IA) or Formula (IB) 1
    Type: Application
    Filed: May 28, 2003
    Publication date: January 15, 2004
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Thomas Martin Kirrane, Daniel Kuzmich, John Robert Proudfoot, David Thomson
  • Fluorescence polarization assay
    Publication number: 20030082665
    Abstract: This invention is directed to a fluorescence polarization assay useful in the detection and evaluation of soluble epoxide hydrolase (sEH) inhibitors. This invention also relates to novel fluorescent probes used in the fluorescence polarization assay, and methods of manufacturing such fluorescent probes.
    Type: Application
    Filed: March 28, 2002
    Publication date: May 1, 2003
    Inventors: Richard Harold Ingraham, Mario G. Cardozo, Christine Anne Grygon, Rachel Rebecca Kroe, John Robert Proudfoot