Abstract: Disclosed herein are system, apparatus, article of manufacture, method and/or computer program product embodiments, and/or combinations and sub-combinations thereof, for an application pre-launch system. An example embodiment operates by detecting a user interaction associated with launching an app configured to operate on a computing device. A first launch command is provided to a server associated with the app. The first launch command is configured to instruct the server to begin loading application data for the app into a cache. Application code of the app is executed, wherein the application code is configured to provide a second launch command to the server. The application data is received from the cache responsive to the second launch command. The app is launched on the computing device using the application data received from the cache. After the launching, the app is configured to receive a user command.

Abstract: Computer implemented systems and methods for providing dynamic lighting through lighting fixtures are provided herein. In one aspect, one or more characteristics of light provided from a lighting fixture or a plurality of lighting fixtures changes over time to shape the environment of an indoor space according to simulated environment illumination parameters and general illumination parameters. Dynamic lighting may improve the health or wellbeing of individuals in an indoor space, for example, by simulating an outdoor environment to reduce stress, by providing circadian entrainment to improve sleep and wakefulness, or the like. Other aspects of the present disclosure enable lighting fixtures to provide light that is synchronized with one or more other devices that simulate an environment and shape the environment of an indoor space.

Abstract: A method for performing magnetic resonance-guided thermal therapy includes selecting a first set of sampling characteristics for acquiring a first set of slabs covering a first anatomical region of interest. Additionally, a second set of sampling characteristics is selected for acquiring a second set of slabs covering a second anatomical region of interest. This second set of sampling characteristics is distinct from the first set of sampling characteristics. An interleaved acquisition of the first set of slabs and the second set of slabs may then be performed using the first set of sampling characteristics and the second set of sampling characteristics.

Abstract: A method that can be used for preparing a poly(dimethyl/methylvinyl) siloxane copolymer is provided. The method includes use of Raman spectroscopy.

Abstract: A multifunctional organosilicon compound is provided which has the general formula XSi([OSiR2]p-0-SiR2Y)a(R1)3-a— ln the formula, X is selected from H and ethylenically un saturated moieties; each Y independently comprises a functional moiety selected from alkoxysilyl moieties, acryloxy moieties, and epoxide moieties; each R is an independently selected hydrocarbyl group; each R1 is an independently selected hydrocarbyl group; subscript a is 1, 2, or 3; and each subscript b is independently 0, 1, or 2. A method of preparing the multifunctional organosilicon compound is also provided. The method comprises reacting (A) an organosilanol compound and (B) a silane compound having at least two hydrolysable groups. A functionalized siloxane compound prepared from the multifunctional organosilicon compound, a method of preparing the functionalized siloxane compound, and an adhesive comprising the functionalized siloxane compound are also provided.

Abstract: A branched organosilanol compound and method for its preparation are provided. The branched organosilanol compound may be used as a starting material in a method for preparing a functionalized polymer.

Abstract: A method of preparing an organosilanol compound is disclosed. The method comprises reacting (A) an initial organosilicon compound and (B) water in the presence of (C) a catalyst. The catalyst (C) is selected from: (C1) [(C8H12irCl]2[(p-cymene)RuCl2]2; and (C3) Pd/C. The initial organosilicon compound (A) has the general formula HO—Si(R)2—[Si(R)2O]a—OSi(R)2—Y and the organosilanol compound has the general formula HO—Si(R)2-[Si(R)2O]a—OSi(R)2—Y, where each R is an independently selected hydrocarbyl group; Y comprises a functional moiety selected from alkoxysilyl moieties, epoxide moieties, and acryloxy moieties, with the proviso that Y is other than the acryloxy moieties when the catalyst (C) is (C3) Pd/C; and subscript a is 0 or 1. The organosilanol compound prepared by the method is also provided.

Abstract: This disclosure provides a method of preparing a silanol-functional organosilicon compound with a cytochrome P450 variant that facilitates the oxidization of a silyl hydride group to a silanol group in the presence of oxygen. The method includes combining the cytochrome P450 variant and an organosilicon compound having at least one silicon-bonded hydrogen atom to give a reaction mixture and exposing the reaction mixture to oxygen to oxidize the organosilicon compound, thereby preparing the silanol-functional organosilicon compound. Cytochrome P450 variants suitable for use in the method are also disclosed, along with methods for engineering and optimizing the same. Nucleic acids encoding the cytochrome P450 variants and compositions, expression vectors, and host cells including the same are also disclosed.

Abstract: Disclosed herein are system, apparatus, article of manufacture, method and/or computer program product embodiments, and/or combinations and sub-combinations thereof, for display dynamic splash screens using a media device during a launch sequence of an application without interrupting or delaying processing of the launch sequence. A launch sequence may be considered to include operations for compiling code associated with the application and operations for displaying splash screens. An example embodiment operates by the media device launching the application responsive to receiving a request and while code for the application is being compiled, selecting and displaying a dynamic splash screen. Operations of compiling code and displaying the splash screen may be performed under the control of the media device operating system and control is passed from the operating system to the application after launch sequence is completed.

Abstract: Disclosed herein are system, apparatus, article of manufacture, method and/or computer program product embodiments, and/or combinations and sub-combinations thereof, for operating a user application including a user rendered context operating on a user device and maintaining a current render tree, and a user programmer context operating on a cloud computing system. The user rendered context of the user application can receive an input; and send, responsive to receiving the input, an event notification to the user programmer context of the user application. The user rendered context can further receive, from the user programmer context, a difference tree to update the current render tree, and update the current render tree based on the difference tree.

Abstract: Disclosed herein are system, apparatus, article of manufacture, method and/or computer program product embodiments, and/or combinations and sub-combinations thereof, for display dynamic splash screens using a media device during a launch sequence of an application without interrupting or delaying processing of the launch sequence. A launch sequence may be considered to include operations for compiling code associated with the application and operations for displaying splash screens. An example embodiment operates by the media device launching the application responsive to receiving a request and while code for the application is being compiled, selecting and displaying a dynamic splash screen. Operations of compiling code and displaying the splash screen may be performed under the control of the media device operating system and control is passed from the operating system to the application after launch sequence is completed.

Abstract: Disclosed herein are system, apparatus, article of manufacture, method and/or computer program product embodiments, and/or combinations and sub-combinations thereof, for operating a user application including a user rendered context operating on a user device and maintaining a current render tree, and a user programmer context operating on a cloud computing system. The user rendered context of the user application can receive an input; and send, responsive to receiving the input, an event notification to the user programmer context of the user application. The user rendered context can further receive, from the user programmer context, a difference tree to update the current render tree, and update the current render tree based on the difference tree.

Abstract: A cooling assembly includes an evaporator containing a primary cooling medium, a passive condenser, and a heat exchanger. When a secondary cooling medium is provided to the heat exchanger, the primary cooling medium in the gas phase switches from being received by the passive condenser to the heat exchanger without operating any valves located between the evaporator and the passive condenser and between the evaporator and the heat exchanger. The primary cooling medium circulates between the evaporator and the passive condenser and between the evaporator and the heat exchanger by natural circulation and gravity without a pump in the flow path of the primary cooling medium between the heat exchanger and the evaporator and between the passive condenser and the evaporator to circulate the primary cooling medium.

Abstract: This disclosure relates to methods for preventing or reducing the risk of development of graft versus host disease (GVHD) in patients receiving hematopoietic cell transplantation (HCT) by particular methods of administering alpha-1 antitrypsin (A1AT or AAT) to patients both prior to and following and HCT procedure. The disclosure also relates to specific methods of treating acute GVHD (aGVHD) after HCT with A1AT.

Abstract: A method for ordering the vehicles of a fleet of vehicles according to a maintenance need includes determining a time series for each vehicle in the fleet. The time series includes, for each time step, an instantaneous value of at least one quantity of interest obtained from monitoring events acquired by a system for monitoring the vehicles of the fleet. The time series is analyzed over a predetermined time interval, considering the time series determined for all the vehicles of the fleet, and considering that at each time step, the state of a vehicle is either a “normal” state or an “abnormal” state. An optimal sequence of states over the predetermined time interval can thereby be obtained. A list of the vehicles of the fleet can be ordered according to the properties of bursts detected for each of the vehicles.

Abstract: An anti-collision system for railcars and locomotives provides a distance ranging and worker coupling protection system utilizing remote-sensing radar techniques for use with a locomotive and railcar. The anti-collision system may include an object detector device attached to a railcar or a locomotive that detects objects in a path of the railcar and the locomotive and a train display device electrically connected to the object detector device. The anti-collision system may also include an emergency action device which enables a crew member to stop the railcar or locomotive without communication to a locomotive operator when a hazard is recognized. The object detector device may include a remote sensor, a radio, and a microprocessor programmed to include data-logging to record and log all data from the anti-collision system.

Abstract: A cooling assembly includes an evaporator containing a primary cooling medium, a passive condenser, and a heat exchanger. When a secondary cooling medium is provided to the heat exchanger, the primary cooling medium in the gas phase switches from being received by the passive condenser to the heat exchanger without operating any valves located between the evaporator and the passive condenser and between the evaporator and the heat exchanger. The primary cooling medium circulates between the evaporator and the passive condenser and between the evaporator and the heat exchanger by natural circulation and gravity without a pump in the flow path of the primary cooling medium between the heat exchanger and the evaporator and between the passive condenser and the evaporator to circulate the primary cooling medium.

Abstract: A method includes the steps of obtaining a frame from an image sensor, the frame comprising a number of pixel values, detecting a change in a first subset of the pixel values, detecting a change in the second subset of the pixel values near the first subset of the pixel values, and determining an occupancy state based on a relationship between the change in the first subset of the pixel values and the second subset of the pixel values. The occupancy state may be determined to be occupied when the change in the first subset of the pixel values is in a first direction and the change in the second subset of the pixel values is in a second direction opposite the first direction.

Abstract: The invention relates to methods of treating antibody-mediated rejection in a subject comprising administering C1-INH to the subject according to a schedule with the following steps: (a) intravenously administering one or more iv-doses of C1-INH, (b) subcutaneously administering at least 10 sc-doses of C1-INH over several weeks, wherein each week at least one sc-dose is administered. The invention further relates to a method of treating antibody-mediated rejection in a transplant recipient comprising subcutaneously administering C1-INH over at least 10 weeks, wherein each week at least one sc-dose is administered.

Abstract: This disclosure relates to methods for preventing or reducing the risk of development of graft versus host disease (GVHD) in patients receiving hematopoietic cell transplantation (HCT) by particular methods of administering alpha-1 antitrypsin (A1AT or AAT) to patients both prior to and following and HCT procedure. The disclosure also relates to specific methods of treating acute GVHD (aGVHD) after HCT with A1AT.