Abstract: Some embodiments provided herein are chimeric costimulatory antigen receptor (CoStAR), useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. In some embodiments, the CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. In some embodiments, CoStAR and/or fusion proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof are also provided.

Abstract: The present invention provides for a method for producing a 4-vinylphenol (4VP) and/or 4-vinylguaiacol (4VG), the method comprising: (a) providing a host cell capable of expressing a polypeptide having a phenolic acid decarboxylase (PAD) enzymatic activity wherein the polypeptide is capable of converting p-coumaric (CA) and/or ferulic acid (FA) into 4-vinylphenol (4VP) and/or 4-vinylguaiacol (4VG), respectively; and (b) culturing the host cell in a culture medium to express the polypeptide such that the polypeptide converts CA and/or FA into 4VP and/or 4VG, respectively; wherein the culture medium comprises an organic overlay or phase.

Abstract: Techniques for tracking compute capacity of a scalable application service platform to perform dynamic bandwidth allocation for data flows associated with applications hosted by the service platform are disclosed. Some of the techniques may include allocating a first amount of bandwidth of a physical underlay of a network for data flows associated with an application. The techniques may also include receiving, from a scalable application service hosting the application, an indication of an amount of computing resources of the scalable application service that are allocated to host the application. Based at least in part on the indications, a second amount of bandwidth of the physical underlay to allocate for the data flows may be determined. The techniques may also include allocating the second amount of bandwidth of the physical underlay of the network for the data flows associated with the application.

Abstract: A cloud-native global file system, in which one or more filers are associated with a volume of a versioned files system in a private, public or hybrid cloud object store, is augmented to include a rapid ransomware recovery service. Upon detecting a ransomware attack associated with one or more files or directories of the volume, read and write access to the volume is restricted. A recovery filer is then activated or designated in the cloud. A restore operation is then initiated at the recovery filter. Following completion of the restore operation, a new clean (healthy) snapshot of the volume is then created using the recovery filer For any filer other than the recovery filer, a determination is made whether the filer has completed a merge operation with respect to the new clean snapshot. If so, read and write access to the volume is re-enabled from that filer.

Abstract: Apparatus for transdermal delivery of a powdered agent to a patient, the apparatus comprising a fluid source comprising a fluid; a nozzle extending distally from the fluid source, the nozzle comprising a proximal end, a distal end and a lumen extending from the proximal end to the distal end; a blister containing a powdered agent disposed within the lumen of the nozzle; and an actuation element for releasing the fluid from the fluid source, wherein the actuation element causes the released fluid to be propelled through the blister with sufficient pressure to entrain the powdered agent into the released fluid and move the entrained powdered agent through the lumen of the nozzle and out the distal end of the nozzle.

Abstract: Disclosed embodiments pertain to protecting sensitive information. A browser extension associated with a web browser can detect a user entering information associated with the user into an electronic form. The browser extension can monitor the user entering sensitive information into the electronic form and detect that the user has entered sensitive information incorrectly. In response, the browser extension can provide a warning to the user that sensitive information has been incorrectly entered. Instructions can be displayed to a user on how incorrectly entered sensitive information is to be corrected. The incorrectly entered sensitive information is corrected based on a response from the user before the sensitive information propagates beyond the electronic form.

Abstract: The present invention provides compounds of the formula: wherein A, B, D1, X, Y, Z, G, R1, R2, and R3a are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients for cancer.

Abstract: Aggregate processing systems, methods and apparatus are described. Some embodiments include a plurality of equipment criteria sensors, product quantity sensors, product characteristic sensors, and/or actuators. Some embodiments include a control system incorporating algorithm logic. Some embodiments include a control system incorporating artificial intelligence logic.

Abstract: Curing of a passivation layer applied to the surface of a ferroelectric integrated circuit so as to enhance the polarization characteristics of the ferroelectric structures. A passivation layer, such as a polyimide, is applied to the surface of the ferroelectric integrated circuit after fabrication of the active devices. The passivation layer is cured by exposure to a high temperature, below the Curie temperature of the ferroelectric material, for a short duration such as on the order of ten minutes. Variable frequency microwave energy may be used to effect such curing. The cured passivation layer attains a tensile stress state, and as a result imparts a compressive stress upon the underlying ferroelectric material. Polarization may be further enhanced by polarizing the ferroelectric material prior to the cure process.

Abstract: A MIPI CSI-2/D-PHY receiving device is configured to handle being hot plugged to MIPI CSI-2/D-PHY transmitting device. During a hot plugging event, the MIPI CSI-2/D-PHY receiving device has not been initialized by receipt from the MIPI CSI-2/D-PHY transmitting device of a Stop State signal of duration TINIT. Though the MIPI CSI-2/D-PHY transmitting device is already transmitting data associated with a partial frame, the MIPI CSI-2/D-PHY receiving device will not enter into an error or unknown state, and will ignore line start/end and frame end events and drop the data packets associated with the partial frame until a frame start event corresponding to a full frame is received from the MIPI CSI-2/D-PHY transmitting device.

Abstract: Example systems, apparatuses, methods, and computer program products are disclosed for electroporating cells in a tissue using a set of voltage pulses generated by capacitor charge circuitry based on a voltage supply. An example method includes continuously monitoring a set of characteristics of the voltage supply and the set of voltage pulses; generating a first set of monitor signals based on the set of characteristics; detecting a first fault condition based on the first set of monitor signals; and generating a first crowbar trigger activation signal. The example computer method further includes: detecting a second fault condition based on a second set of monitor signals generated based on the first set of monitor signals; and generating a second crowbar trigger activation signal. Subsequently, the example computer method includes electrically disconnecting the capacitor charge circuitry from electroporation electrode circuitry based on either the first or second crowbar trigger activation signal.

Abstract: A MIPI CSI-2/D-PHY receiving device is configured to handle being hot plugged to MIPI CSI-2/D-PHY transmitting device. During a hot plugging event, the MIPI CSI-2/D-PHY receiving device has not been initialized by receipt from the MIPI CSI-2/D-PHY transmitting device of a Stop State signal of duration TINIT. Though the MIPI CSI-2/D-PHY transmitting device is already transmitting data associated with a partial frame, the MIPI CSI-2/D-PHY receiving device will not enter into an error or unknown state, and will ignore line start/end and frame end events and drop the data packets associated with the partial frame until a frame start event corresponding to a full frame is received from the MIPI CSI-2/D-PHY transmitting device.

Abstract: Example systems, apparatuses, methods, and computer program products are disclosed for electroporating cells in a tissue using a set of voltage pulses generated by capacitor charge circuitry based on a voltage supply. An example method includes continuously monitoring a set of characteristics of the voltage supply and the set of voltage pulses; generating a first set of monitor signals based on the set of characteristics; detecting a first fault condition based on the first set of monitor signals; and generating a first crowbar trigger activation signal. The example computer method further includes: detecting a second fault condition based on a second set of monitor signals generated based on the first set of monitor signals; and generating a second crowbar trigger activation signal. Subsequently, the example computer method includes electrically disconnecting the capacitor charge circuitry from electroporation electrode circuitry based on either the first or second crowbar trigger activation signal.

Abstract: Example systems, apparatuses, methods, and computer program products are disclosed for electroporating cells in a tissue using a set of voltage pulses generated by capacitor charge circuitry based on a voltage supply. An example method includes continuously monitoring a set of characteristics of the voltage supply and the set of voltage pulses; generating a first set of monitor signals based on the set of characteristics; detecting a first fault condition based on the first set of monitor signals; and generating a first crowbar trigger activation signal. The example computer method further includes: detecting a second fault condition based on a second set of monitor signals generated based on the first set of monitor signals; and generating a second crowbar trigger activation signal. Subsequently, the example computer method includes electrically disconnecting the capacitor charge circuitry from electroporation electrode circuitry based on either the first or second crowbar trigger activation signal.

Abstract: A system includes a ferroelectric random access memory (FRAM) array having one or more memory elements. A cycle controller cycles data to be fixed in a subset of the one or more memory elements by reading or writing the data a predetermined number of times to fix the data to a non-volatile stable state.

Abstract: Disclosed embodiments include a testing system that electrically connects to an integrated circuit (IC) having ferroelectric memory (FRAM) cells. The testing system programs the FRAM cells to a first data state and then iteratively reads the programmed cells at a plurality of reference voltages to identify a reference voltage limit that indicates a first occurrence at which at least one of the cells fails to return the first data state when read. Iteratively reading the cells includes reading each cell at an initial reference voltage at which all the cells return the first data state, and then reading each of the programmed cells at each of the remaining reference voltages by incrementally changing the initial reference voltage in one direction until the reference voltage limit is identified. The testing system sets the reference in the IC at an operating level based on the reference voltage limit.

Abstract: A system includes a ferroelectric random access memory (FRAM) array having one or more memory elements. A cycle controller cycles data to be fixed in a subset of the one or more memory elements by reading or writing the data a predetermined number of times to fix the data to a non-volatile stable state.

Abstract: A data retention reliability screen of integrated circuits including ferroelectric random access memory (FRAM) arrays. Sampled groups of cells in the FRAM array are tested at various reference voltage levels, after programming to a high polarization capacitance data state and a relaxation time at an elevated temperature. Fail bit counts of the sample groups at the various reference voltage levels are used to derive a test reference voltage, against which all of the FRAM cells in the integrated circuit are then tested after preconditioning (i.e., programming) and another relaxation interval at the elevated temperature, to determine those cells in the integrated circuit that are vulnerable to long-term data retention failure.

Abstract: Described herein are compositions and methods related to isolated Trichoderma harzianum and strains thereof.

Abstract: The present invention provides thieno[2,3-c]pyrrol-4-one compounds that inhibit activity of extracellular-signal-regulated kinase (ERK) and may be useful in the treatment of cancer.