Patents by Inventor John Rosazza

John Rosazza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polypeptides and biosynthetic pathways for the production of monatin and its precursors
    Patent number: 9034610
    Abstract: Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
    Type: Grant
    Filed: April 4, 2013
    Date of Patent: May 19, 2015
    Assignee: CARGILL, INCORPORATED
    Inventors: Timothy W. Abraham, Douglas C. Cameron, Paula M. Hicks, Sara C. McFarlan, James R. Millis, John Rosazza, David P. Weiner, Lishan Zhao
  • Polypeptides and biosynthetic pathways for the production of monatin and its precursors
    Patent number: 8435765
    Abstract: Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
    Type: Grant
    Filed: May 20, 2008
    Date of Patent: May 7, 2013
    Assignee: Cargill, Incorporated
    Inventors: Timothy W. Abraham, Douglas C. Cameron, Paula M. Hicks, Sara C. McFarlan, James R. Millis, John Rosazza, David P. Weiner, Lishan Zhao
  • Polypeptides and biosynthetic pathways for the production of monatin and its precursors
    Patent number: 8372989
    Abstract: Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
    Type: Grant
    Filed: November 3, 2004
    Date of Patent: February 12, 2013
    Assignee: Cargill, Incorporated
    Inventors: Timothy W. Abraham, Douglas C. Cameron, Paula M. Hicks, Sara C. McFarlan, John Rosazza, Lishan Zhao, David P. Weiner
  • Production of monatin and monatin precursors
    Patent number: 8206955
    Abstract: Methods and compositions that can be used to make monatin or salt thereof from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
    Type: Grant
    Filed: October 21, 2004
    Date of Patent: June 26, 2012
    Assignee: Cargill, Incorporated
    Inventors: Sara C. McFarlan, Paula M. Hicks, Mary Jo Zidwick, Fernando A. Sanchez-Riera, Douglas C. Cameron, Mervyn L. deSouza, John Rosazza, Steven J. Gort, Timothy W. Abraham
  • Polypeptides and biosynthetic pathways for the production of monatin and its precursors
    Patent number: 7572607
    Abstract: Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
    Type: Grant
    Filed: April 26, 2005
    Date of Patent: August 11, 2009
    Assignee: Cargill, Incorporated
    Inventors: Paula M. Hicks, Sara C. McFarlan, Timothy W. Abraham, Douglas C. Cameron, James R. Millis, John Rosazza, Lishan Zhao, David Paul Weiner
  • Beverage Compositions Comprising Monatin and Methods of Making Same
    Publication number: 20090130285
    Abstract: The present invention relates to novel beverage compositions comprising monatin and methods for making such compositions. The present invention also relates to beverage compositions comprising specific monatin stereoisomers, specific blends of monatin stereoisomers, and/or monatin produced via a biosynthetic pathway in vivo (e.g., inside cells) or in vitro.
    Type: Application
    Filed: November 14, 2008
    Publication date: May 21, 2009
    Inventors: Timothy W. Abraham, Douglas C. Cameron, Melanie J. Goulson, Paula M. Hicks, Michael G. Lindley, Sara C. McFarlan, James R. Millis, John Rosazza, Lishan Zhao, David P. Weiner
  • Polypeptides and Biosynthetic Pathways for the Production of Monatin and Its Precursors
    Publication number: 20090117625
    Abstract: Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
    Type: Application
    Filed: May 20, 2008
    Publication date: May 7, 2009
    Applicant: Cargill, Incorporated
    Inventors: Timothy W. Abraham, Douglas C. Cameron, Paula M. Hicks, Sara C. McFarlan, Jim Millis, John Rosazza, Lishan Zhao, David P. Weiner
  • Carboxylic acid reductase polypeptide, nucleotide sequence encoding same and methods of use
    Publication number: 20060199254
    Abstract: The invention provides the nucleotide sequence and amino acid sequence for the enzyme carboxylic acid reductase isolated from bacteria. Expression cassettes, vectors, transformed cells, and variants are also provided as methods for use of recombinant biocatalytic reagents in production of synthetic, aromatic, aliphatic and alicyclic aldehydes and alcohols.
    Type: Application
    Filed: May 10, 2006
    Publication date: September 7, 2006
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION, INC.
    Inventors: John Rosazza, Ian Fotheringham, Tao Li, Lacy Daniels, Aimin He
  • Polypeptides and biosynthetic pathways for the production of monatin and its precursors
    Publication number: 20050244937
    Abstract: Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for produding the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
    Type: Application
    Filed: November 3, 2004
    Publication date: November 3, 2005
    Inventors: Timothy Abraham, Douglas Cameron, Paula Hicks, Sara McFarlan, Jim Millis, John Rosazza, Lishan Zhao, David Weiner
  • Production of monatin and monatin precursors
    Publication number: 20050221455
    Abstract: Methods and compositions that can be used to make monatin or salt thereof from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
    Type: Application
    Filed: October 21, 2004
    Publication date: October 6, 2005
    Inventors: Sara McFarlan, Paula Hicks, Mary Zidwick, Fernando Sanchez-Riera, Douglas Cameron, Mervyn deSouza, John Rosazza, Steven Gort, Timothy Abraham
  • Chewing gum compositions comprising monatin and methods for making same
    Publication number: 20050170041
    Abstract: Chewing gum compositions are described that include one or more stereoisomers of monatin, a naturally occurring high-intensity sweetener.
    Type: Application
    Filed: August 16, 2004
    Publication date: August 4, 2005
    Inventors: Timothy Abraham, Douglas Cameron, Melanie Goulson, Paula Hicks, Michael Lindley, Sara McFarlan, James Millis, John Rosazza, Lishan Zhao, David Weiner
  • Monatin tabletop sweetener compositions and methods of making same
    Publication number: 20050112260
    Abstract: The present invention relates to novel sweetener compositions comprising monatin and methods for making such compositions. The present invention also relates to sweetener compositions comprising specific monatin stereoisomers, specific blends of monatin stereoisomers, and/or monatin produced via a biosynthetic pathway in vivo (e.g., inside cells) or in vitro.
    Type: Application
    Filed: August 2, 2004
    Publication date: May 26, 2005
    Inventors: Timothy Abraham, Douglas Cameron, Melanie Goulson, Paula Hicks, Michael Lindley, Sara McFarlan, James Millis, John Rosazza, Lishan Zhao, David Weiner
  • Beverage compositions comprising monatin and methods of making same
    Publication number: 20050106305
    Abstract: The present invention relates to novel beverage compositions comprising monatin and methods for making such compositions. The present invention also relates to beverage compositions comprising specific monatin stereoisomers, specific blends of monatin stereoisomers, and/or monatin produced via a biosynthetic pathway in vivo (e.g., inside cells) or in vitro.
    Type: Application
    Filed: August 25, 2004
    Publication date: May 19, 2005
    Inventors: Timothy Abraham, Douglas Cameron, Melanie Goulson, Paula Hicks, Michael Lindley, Sara McFarlan, James Millis, John Rosazza, Lishan Zhao, David Weiner