Abstract: The present invention is related to the production of bio-based carotenoids, particularly to methods for enhancing the titer and purity of beta-carotene fermentation in a suitable host cell.

Abstract: The present invention provides genetically engineered host organisms capable of producing terpenoids. The present invention also relates terpenoids obtained from such genetically engineered organisms. Examples of the produced terpenoids include carotenoids, ionones, abienol, and other isoprenoid derived compounds. In addition, the invention relates to a methods of for the preparation of terpenoids using such a genetically engineered organism.

Abstract: Aspects of the present disclosure relate to detecting an optical signal and/or optical power in a ferrule-less optical fiber. In certain embodiments, one or more optical detectors are incorporated into an adapter that is configured to interface with a connectorized or non-connectorized ferrule-less optical fiber. The optical detector detects the presence or absence, and/or the optical power level, of the optical signal being transmitted through ferrule-less optical fiber and produces an electrical output representative of the detected optical signal.

Abstract: The present disclosure relates to a novel method, expression vectors, and host cells for producing abienol by converting geranylgeranyl diphosphate (GGPP) to abienol in the presence of a combination of a class II diterpene synthase and a bifunctional class I/II abienol synthase.

Abstract: Aspects of the present disclosure relate to detecting an optical signal and/or optical power in a ferrule-less optical fiber. In certain embodiments, one or more optical detectors are incorporated into an adapter that is configured to interface with a connectorized or non-connectorized ferrule-less optical fiber. The optical detector detects the presence or absence, and/or the optical power level, of the optical signal being transmitted through ferrule-less optical fiber and produces an electrical output representative of the detected optical signal.

Abstract: The present invention provides genetically engineered host organisms capable of producing terpenoids. The present invention also relates terpenoids obtained from such genetically engineered organisms. Examples of the produced terpenoids include carotenoids, ionones, abienol, and other isoprenoid derived compounds. In addition, the invention relates to a methods of for the preparation of terpenoids using such a genetically engineered organism.

Abstract: The present invention relates to a recombinant host capable of producing a steviol glycoside comprising a recombinant nucleic acid sequence encoding a polypeptide having geranylgeranyl pyrophosphate (GGPP) synthase activity which comprises the amino acid sequence set forth in SEQ ID NO: 1 or an amino acid sequence having at least about 45% sequence identity thereto.

Abstract: The present disclosure relates to a novel method, expression vectors, and host cells for producing abienol by converting geranylgeranyl diphosphate (GGPP) to abienol in the presence of a combination of a class II diterpene synthase and a bifunctional class I/II abienol synthase.

Abstract: Implementations described and claimed herein provide a system and methods for balancing network loads across distinct provider networks. In one implementation, a virtual network representative of at least a first provider network is established having at least one interconnection point where network traffic is exchanged between the first provider network and a second provider network and having at least one provider edge port and at least one potential interconnection point. A measurement of a bandwidth between the at least one provider edge port and the at least one interconnection point is obtained. A measurement of a distance between the at least one provider edge port and a geographically closest of the at least one potential interconnection point or the at least one interconnection point is obtained. A network load indication for the first provider network as a function of the bandwidth measurement and the distance measurement is obtained.

Abstract: Implementations described and claimed herein provide systems and methods for balancing network loads across distinct provider networks using enriched network traffic flow data. In one implementation, network traffic flow data representative of network traffic exchanged between a first provider network and a second provider network is generated. The network traffic flow data is enriched using at least one enrichment feed. A network load indication for the first provider network is calculated using the enriched network traffic flow data. The network load indication is a function of a bandwidth measurement and a distance measurement.

Abstract: Implementations described and claimed herein provide a system and methods for balancing network loads across distinct provider networks. In one implementation, a virtual network representative of at least a first provider network is established having at least one interconnection point where network traffic is exchanged between the first provider network and a second provider network and having at least one provider edge port and at least one potential interconnection point. A measurement of a bandwidth between the at least one provider edge port and the at least one interconnection point is obtained. A measurement of a distance between the at least one provider edge port and a geographically closest of the at least one potential interconnection point or the at least one interconnection point is obtained. A network load indication for the first provider network as a function of the bandwidth measurement and the distance measurement is obtained.

Abstract: Implementations described and claimed herein provide a system and methods for balancing network loads across distinct provider networks. In one implementation, a virtual network representative of at least a first provider network is established having at least one interconnection point where network traffic is exchanged between the first provider network and a second provider network and having at least one provider edge port and at least one potential interconnection point. A measurement of a bandwidth between the at least one provider edge port and the at least one interconnection point is obtained. A measurement of a distance between the at least one provider edge port and a geographically closest of the at least one potential interconnection point or the at least one interconnection point is obtained. A network load indication for the first provider network as a function of the bandwidth measurement and the distance measurement is obtained.

Abstract: Implementations described and claimed herein provide systems and methods for balancing network loads across distinct provider networks using enriched network traffic flow data. In one implementation, network traffic flow data representative of network traffic exchanged between a first provider network and a second provider network is generated. The network traffic flow data is enriched using at least one enrichment feed. A network load indication for the first provider network is calculated using the enriched network traffic flow data. The network load indication is a function of a bandwidth measurement and a distance measurement.

Abstract: Implementations described and claimed herein provide a system and methods for balancing network loads across distinct provider networks. In one implementation, a virtual network representative of at least a first provider network is established having at least one interconnection point where network traffic is exchanged between the first provider network and a second provider network and having at least one provider edge port and at least one potential interconnection point. A measurement of a bandwidth between the at least one provider edge port and the at least one interconnection point is obtained. A measurement of a distance between the at least one provider edge port and a geographically closest of the at least one potential interconnection point or the at least one interconnection point is obtained. A network load indication for the first provider network as a function of the bandwidth measurement and the distance measurement is obtained.

Abstract: The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.

Abstract: Methods for improving secondary metabolite production by modulating certain genes involved in secondary metabolite production, including genes encoding CreA, AreA, GanB, Gna3, FadA, Gna1, Gpa1, RfeH, An09, PacC, Lys14, LovU, Ste7, Pde2, Nc1, Vps34 and fungal homologs thereof.

Abstract: The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.

Abstract: The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a mutant of a parent filamentous fungal cell under conditions conducive for the production of the polypeptide, wherein (i) the mutant cell comprises a first nucleic acid sequence encoding the polypeptide and a second nucleic acid sequence comprising a modification of at least one of the genes involved in the production of a trichothecene and (ii) the mutant produces less of the trichothecene than the parent filamentous fungal cell when cultured under the same conditions; and (b) isolating the polypeptide from the cultivation medium. The present invention also relates to mutants of filamentous fungal cells and methods for obtaining the mutant cells. The present invention also relates to isolated trichodiene synthases and isolated nucleic acid sequences encoding the trichodiene synthases.

Abstract: The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.

Abstract: An oscillating sprinkler having improved provision for confining fluid discharge to a predetermined arc through which the sprinkler reciprocates, including a nozzle adapted to direct a stream along an axis in predetermined relation thereto, a pair of cooperative concave vanes; and means mounting the vanes in fixed spaced relation for integral movement to and from the stream with their concavities disposed toward a predetermined fluid path therebetween, one of the vanes being adjacent to the nozzle and having an inner end disposed theretoward in acute angular relation to the axis when in the stream and an opposite end curved laterally from the axis, the other vane being spaced laterally and longitudinally of the axis from said one vane in the direction of curvature thereof having an inner end substantially parallel to said opposite end of said one vane and an opposite end substantially parallel to the inner end of said one vane.