Abstract: Disclosed herein are compositions comprising an oligonucleotide that targets MST1. The oligonucleotide may include a small interfering RNA (siRNA) or an antisense oligonucleotide (ASO). Also provided herein are methods of treating conditions associated with MST1 mutations that include providing an oligonucleotide that targets MST1 to a subject.

Abstract: A molding arrangement is provided for multi-level stack molds wherein mold sets and runners are made up of modular sections interchangeable individually or as larger assemblies for exchanging molds for one part for those for different parts or exchanging runners between hot tip and valve gate designs to accommodate different molding arrangements. The arrangement has discrete melt paths for each mold level, at least some of which extend around rather than through the mold levels and which incorporate readily separable connectors. This enables one set of molds and possibly as well the runners for one mold level to be interchanged without interfering with the mold and runner arrangement for an adjacent level.

Abstract: A network capacity management system and method are disclosed. In one form, a capacity management system for use with an optical network includes a network capacity management engine operable to actively access a network element. The system further includes a network-based application interface associated with the network capacity management engine. The application may facilitate providing information associated with a network element to a user in near real-time.

Abstract: A process for the preparation of a compound (I) ##STR1## wherein R is a hydroxyl protecting group which comprises isomerising a compound of formula (I) wherein R is a hydroxyl protecting group by reacting the compound of formula (I) with a sterically hindered organic base in the presence of a Lewis acid and a compound of forumula (III) ##STR2## wherein R.sub.1 and R.sub.2 each independently represent cyano, COR.sub.5 or COR.sub.2 R.sub.6 or R.sub.1 andR.sub.2 together with the carbon atom to which they are attached from a C.dbd.O group;R.sub.5 represents alkyl, cycloalkyl, amino, alkylamino, dialkyl amino or optionally substituted phenyl or phenylalkyl group;R.sub.6 represents alkyl, cycloalkyl or optionally substituted phenyl or phenylalkyl group;R.sub.3 and R.sub.4 represent each independently hydrogen, alkyl, alkoxy or optionally substituted phenyl group.