Abstract: A method for selecting cancer patient for treatment with Seneca Valley Virus (SVV) by determining expression of ANTXR1 in a cancerous tissue in a cancer patient; and designating the cancer patient as a candidate for treatment with SVV if normal levels or elevated levels of ANTXR1 expression is detected in the cancerous tissue. Also a method for treating a cancer patient with SVV is disclosed.

Abstract: It is an object of the present invention to provide an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody-drug conjugate and having therapeutic effects on a tumor, a method for treating a tumor using the antibody-drug conjugate or the pharmaceutical composition, and the like. The present invention provides an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor.

Abstract: The present invention provides a novel anti-DLL3 antibody-pyrrolodiazepine derivative and a novel anti-DLL3 anti-body-pyrrolodiazepine derivative conjugate using the same.

Abstract: An adaptive camouflage device that includes at least one non-emissive layer which includes a guest-host liquid crystal (GHLC).

Abstract: An adaptive camouflage device that includes at least one non-emissive layer which includes a guest-host liquid crystal (GHLC).

Abstract: A medication reminder system, comprising a control device operable to receive data representing a dosage regime for the medication for use with an electronic tag, the tag communicatively coupled to a display device to be placed on or in association with an item containing the medication, the tag including a transceiver operable to send and receive data to and from the control device, wherein the display device is operable to display an indicator representing the dosage regime or a parameter associated with the dosage regime.

Abstract: The invention includes systems and methods for improving the performance of non-blocking data switching systems. One embodiment of the invention includes a method comprising routing data from a plurality of inputs to a plurality of outputs through a switching core according to a first switching schedule, receiving a first set of reports comprising reports from data sources associated with the plurality of inputs, evaluating one or more reports of the first set of reports, determining a sufficiency of the first switching schedule based on the one or more reports, adapting a second switching schedule, wherein the second switching schedule differs from the first switching schedule, sending the second switching schedule to the data sources, issuing one or more synchronization signals associated with a transition to the second switching schedule to the data sources and routing data from the plurality of inputs to the plurality of outputs through the switching core according to the second switching schedule.

Abstract: A colour display device comprises: a first display substrate (13) and a second display substrate (18), said substrates being spaced apart and opposed to each other; a layer of an electro-optic material (27) between the substrates; a set of first electrodes (17a) on an inner surface of the first display substrate (13) and a set of second electrodes (17b) on an inner surface of the second display substrate (18), the first electrodes (17a) overlapping the second electrodes (17b) to define pixels for selectively applying an electric field across at least some of said electro-optic material; a set of first colour filters (CY) on the first display substrate, each of said first electrodes being in register with one of said first colour filters; and a set of second colour filters (CM) on the second display substrate, each of said second electrodes being in register with one of said second colour filters.

Abstract: A method of applying to a display substrate colour elements and addressing busbars in a defined alignment relative to each other includes: forming said colour elements and said busbars on a surface of a transfer carrier; 10 adhering said colour elements and said busbars to said display substrate; and removing said transfer carrier.

Abstract: A transistor device having a metallic source electrode, a metallic drain electrode, a metallic gate electrode and a channel in a deposited semiconductor material, the transistor device comprising: a first layer comprising the metallic gate electrode, a first metal portion of the metallic source electrode and a first metal portion of the metallic drain electrode; a second layer comprising a second metal portion of the metallic source electrode, a second metal portion of the metallic drain electrode, the deposited semiconductor material and dielectric material between the semiconductor material and the metallic gate electrode; and a third layer comprising a substrate, wherein the first, second and third layers are arranged in order such that the second layer is positioned between the first layer and the third layer.

Abstract: A cross-over (140); of first (142) and second (144) separate elongate conductive interconnects, comprising: a first elongate conductive interconnect (142); a first conductive portion (110a) separate from the first elongate conductive interconnect (142); a second conductive portion (110b) separate from the first elongate conductive interconnect (142); first insulating material (122) adjacent at least a portion (111) of the first elongate conductive interconnect (142); and a third electro-deposited metal portion (124) extending adjacent the first insulating material (122) to interconnect the first (110a) and second (110b) conductive portions, wherein the first (110a), second (110b) and third (124) portions are interconnected portions of the second elongate conductive interconnect (144); and a substrate, wherein the first insulating material and the third electro-deposited metal portion are positioned between the substrate and the first elongate conductive interconnect.

Abstract: A laminated article comprises a first substrate and a second substrate at least one of which is flexible, the substrates being spaced apart from each other by spacing means and enclosing a layer of a fluid material. At least some of the spacing means comprise wall structures enclosing an adhesive material which adheres the substrates together. Fluid material which is outside the wall structures is isolated from the adhesive material and any fluid material within the wall structures. Another aspect of the invention provides a method of manufacturing the article.

Abstract: Methods and systems for dynamically computing a schedule defining interconnections between ports in a switching system. In one embodiment, a switching core requests demand reports from the ingress ports. In response to this request, the ingress ports generate a series of suggested port schedules, beginning with a first choice, then a second choice, and so on. The schedules are transmitted to the switching core, beginning with the first choice. The switching core receives the first choice for each of the ports and determines whether the aggregate schedule defined by the first choices is valid. If the aggregate schedule is valid, then this schedule is implemented. If the aggregate schedule is not valid, portions of it are discarded and the next choice from each of the ports is examined to identify connections to replace the discarded portions. This process is repeated until a valid schedule is obtained.

Abstract: A semiconductor device comprising: a first electrode component; a second electrode component; a first layer comprising at least a portion of the first electrode component and at least a portion of the second electrode component; a second layer having a portion comprising deposited semiconductor material contacting the first and second electrode components; and a third layer comprising a substrate, wherein the first, second and third layers are arranged in order such that the second layer is positioned between the first layer and the third layer and wherein the first and second electrode components comprise electro-deposited metal.

Abstract: A method for forming a metal-insulator-metal device includes imprinting at least one first layer to form a first impression, removing a portion of at least one second layer through the first depression to form a recess in the at least one second layer bordered by a first side, a first overhang along the first side, a second opposite side and a second overhang along the second side. The method also includes depositing a first metal in the recess spaced from the first side and the second side and oxidizing the first metal to create a non-linear dielectric.

Abstract: A non-blocking optical matrix core switching method that includes maintaining a schedule for routing data through an optical matrix core and receiving and analyzing reports from peripheral devices. The method determines whether the schedule is adequate for the current data traffic patterns and if the schedule is not adequate a new schedule is implemented. The new schedule is then transferred to the peripheral devices for implementation and the new schedule is transferred to the optical matrix core scheduler. Implementation of the new schedule as the schedule on the peripheral devices and the optical matrix core scheduler is then performed.

Abstract: A metal-insulator-metal device includes a layer having a major dimensional surface. The layer has a first portion having a first boundary, a second metal portion having a second boundary facing the first boundary in a direction parallel to the surface and a non-linear dielectric between the first boundary and the second boundary and having a thickness orthogonal to the surface.

Abstract: A process is described for fabricating an active addressing component such as a metal-insulator-metal (MIM) device by creating surface relief levels to form trenches, and depositing a metal in the trenches. The metal is anodized to create a non-linear dielectric. A second metal is deposited in the trenches to create an electrical with the dielectric which a contact is provided, and transferring the MIM device to a substrate by adhesive transfer.

Abstract: A process is described for fabricating an active addressing component such as a metal-insulator-metal (MIM) device by creating surface relief levels to form trenches, and depositing a metal in the trenches. The metal is anodized to create a non-linear dielectric. A second metal is deposited in the trenches to create an electrical with the dielectric which a contact is provided, and transferring the MIM device to a substrate by adhesive transfer.

Abstract: A projection screen is provided that includes a display surface having a plurality of elements. Each element has an optical property that is responsive to an appropriate applied voltage. The display surface may be configured so that the optical properties of each element may be coordinated with the projected image.