Patents by Inventor John Rudolph Desjarlais

John Rudolph Desjarlais has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fc variants with altered binding to FcRn
    Patent number: 8802820
    Abstract: The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: August 12, 2014
    Assignee: Xencor, Inc.
    Inventors: Aaron Keith Chamberlain, Bassil I. Dahiyat, John Rudolph Desjarlais, Sher Bahadur Karki, Gregory Alan Lazar
  • OPTIMIZED Fc VARIANTS AND METHODS FOR THEIR GENERATION
    Publication number: 20120230980
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: January 9, 2012
    Publication date: September 13, 2012
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John Rudolph Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Methods for rational pegylation of proteins
    Patent number: 7587286
    Abstract: The present invention relates to the use of simulation technology to rationally optimize the locations and sizes of attached polymeric moieties for modification of therapeutic proteins and the proteins generated from this method.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: September 8, 2009
    Assignee: Xencor, Inc.
    Inventors: John Rudolph Desjarlais, Jonathan Zalevsky
  • Optimized Fc variants and methods for their generation
    Publication number: 20090092599
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: October 31, 2007
    Publication date: April 9, 2009
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John Rudolph Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Optimized Fc variants and methods for their generation
    Publication number: 20090081208
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: October 31, 2007
    Publication date: March 26, 2009
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John Rudolph Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Optimized Fc variants and methods for their generation
    Publication number: 20090068177
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: October 31, 2007
    Publication date: March 12, 2009
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John Rudolph Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Fc VARIANTS WITH ALTERED BINDING TO FcRn
    Publication number: 20090041770
    Abstract: The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes.
    Type: Application
    Filed: October 31, 2007
    Publication date: February 12, 2009
    Inventors: Aaron Keith CHAMBERLAIN, Bassil I. Dahiyat, John Rudolph Desjarlais, Sher Bahadur Karki
  • Methods for rational pegylation of proteins
    Publication number: 20040249576
    Abstract: The present invention relates to the use of simulation technology to rationally optimize the locations and sizes of attached polymeric moieties for modification of therapeutic proteins and the proteins generated from this method.
    Type: Application
    Filed: March 31, 2004
    Publication date: December 9, 2004
    Applicant: Xencor
    Inventors: John Rudolph Desjarlais, Jonathan Zalevsky
  • Novel proteins with altered immunogenicity
    Publication number: 20040230380
    Abstract: The present invention provides methods for combining computational methods for modulating protein immunogenicity with computational methods for identifying sequences with desired structural and functional properties. More specifically, the methods of the present invention may be used to identify modifications that increase or decrease the immunogenicity of a protein by affecting antigen uptake, MHC binding, T-cell binding, or antibody binding, while retaining or enhancing functional properties.
    Type: Application
    Filed: January 8, 2004
    Publication date: November 18, 2004
    Applicant: Xencor
    Inventors: Arthur J. Chirino, Bassil I. Dahiyat, John Rudolph Desjarlais, Shannon Alicia Marshall
  • Novel proteins with antiviral, antineoplastic, and/or immunomodulatory activity
    Publication number: 20040175359
    Abstract: The invention relates to interferon variants with improved properties and methods for their use.
    Type: Application
    Filed: September 30, 2003
    Publication date: September 9, 2004
    Inventors: John Rudolph Desjarlais, Shannon Alicia Marshall, Yirong Mo, Adam Read Thomason
  • Interferon variants with improved properties
    Publication number: 20040137581
    Abstract: The invention relates to interferon variants with improved properties and methods for their use.
    Type: Application
    Filed: September 30, 2003
    Publication date: July 15, 2004
    Applicant: Xencor
    Inventors: Anna Marie Aguinaldo, Amelia Joy Beyna, Ho Sung Cho, John Rudolph Desjarlais, Shannon Alicia Marshall, Umesh Muchhal, Michael Francis Aquino Villegas, Eugene Zhukovsky
  • Optimized Fc variants and methods for their generation
    Publication number: 20040132101
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: September 26, 2003
    Publication date: July 8, 2004
    Applicant: Xencor
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John Rudolph Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa