Patents by Inventor John Russell Falck

John Russell Falck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYP-eicosanoid derivatives
    Patent number: 11130772
    Abstract: The present invention relates to compounds according to general formula (I) which are analogues of epoxymetabolites produced by cytochrome P450 (CYP) enzymes from omega-3 (n-3) polyunsaturated fatty acids (PUFAs). The present invention further relates to compositions containing one or more of these compounds and to the use of these compounds or compositions for the treatment or prevention of conditions and diseases associated with inflammation, proliferation, hypertension, coagulation, immune function, pathologic angiogenesis, heart failure and cardiac arrhythmias.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: September 28, 2021
    Inventors: Wolf-Hagen Schunck, Dominik Mueller, Robert Fischer, Gerd Wallukat, Anne Konkel, John Russell Falck
  • Metabolically robust analogs of CYP-eicosanoids for the treatment of cardiac disease
    Patent number: 11096910
    Abstract: The present invention relates to compounds according to general formula (I) which are metabolically robust analogues of bioactive lipid mediators derived from omega-3 polyunsaturated fatty acids (n-3 PUFAs). The present invention further relates to compositions containing one or more of these compounds and to the use of these compounds or compositions for the treatment or prevention of cardiovascular diseases.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: August 24, 2021
    Assignees: Max Delbruck-Centrum Fur Molekulare Medizin, The Board of Regents of the University of Texas System, Omeicos Therapeutics GmbH
    Inventors: Robert Fischer, Anne Konkel, Tim Wesser, Philipp Westphal, Wolf-Hagen Schunk, Christina Westphal, John Russell Falck
  • METABOLICALLY ROBUST ANALOGS OF CYP-EICOSANOIDS FOR THE TREATMENT OF CARDIAC DISEASE
    Publication number: 20190133976
    Abstract: The present invention relates to compounds according to general formula (I) which are metabolically robust analogues of bioactive lipid mediators derived from omega-3 polyunsaturated fatty acids (n-3 PUFAs). The present invention further relates to compositions containing one or more of these compounds and to the use of these compounds or compositions for the treatment or prevention of cardiovascular diseases.
    Type: Application
    Filed: July 22, 2016
    Publication date: May 9, 2019
    Inventors: Robert FISCHER, Anne KONKEL, Tim WESSER, Philipp WESTPHAL, Wolf-Hagen SCHUNK, Christina WESTPHAL, John Russell FALCK
  • Direct stereospecific synthesis of unprotected aziridines from olefins
    Patent number: 9988349
    Abstract: A method for the direct stereospecific conversion of structurally diverse mono-, di-, tri- and tetra-substituted olefins to N—H, N-alkyl, N-cycloalkyl, or N-aralkyl aziridines using a hydroxylamine amination agent with transition metal catalyst. The method is operationally simple (i.e., one-pot), scalable and fast at ambient temperature.
    Type: Grant
    Filed: January 3, 2015
    Date of Patent: June 5, 2018
    Inventors: Daniel Halsell Ess, John Russell Falck, Jawahar Lal Jat, Laszlo Kurti
  • NOVEL CYP-EICOSANOID DERIVATIVES
    Publication number: 20170008918
    Abstract: The present invention relates to compounds according to general formula (I) which are analogues of epoxymetabolites produced by cytochrome P450 (CYP) enzymes from omega-3 (n-3) polyunsaturated fatty acids (PUFAs). The present invention further relates to compositions containing one or more of these compounds and to the use of these compounds or compositions for C the treatment or prevention of conditions and diseases associated with inflammation, proliferation, hypertension, coagulation, immune function, pathologic angiogenesis, heart failure and cardiac arrhythmias.
    Type: Application
    Filed: January 21, 2015
    Publication date: January 12, 2017
    Inventors: Wolf-Hagen Schunck, Dominik Mueller, Robert Fischer, Gerd Wallukat, Anne Konkel, John Russell Falck
  • DIRECT STEREOSPECIFIC SYNTHESIS OF UNPROTECTED AZIRIDINES FROM OLEFINS
    Publication number: 20160340305
    Abstract: A method for the direct stereospecific conversion of structurally diverse mono-, di-, tri- and tetra-substituted olefins to N—H, N-alkyl, N-cycloalkyl, or N-aralkyl aziridines using a hydroxylamine amination agent with transition metal catalyst. The method is operationally simple (i.e., one-pot), scalable and fast at ambient temperature.
    Type: Application
    Filed: January 3, 2015
    Publication date: November 24, 2016
    Inventors: Daniel Halsell ESS, John Russell FALCK, Jawahar Lal JAT, Laszlo URTI
  • Epoxyeicosatrienoic acid analogs and methods of making and using the same
    Patent number: 9422318
    Abstract: Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of making and using the compounds and compositions are further described.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: August 23, 2016
    Assignees: The Medical College of Wisconsin, Inc., The Board of Regents of the University of Texas System
    Inventors: John David Imig, William B. Campbell, John Russell Falck
  • EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20150336916
    Abstract: Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of making and using the compounds and compositions are further described.
    Type: Application
    Filed: July 30, 2015
    Publication date: November 26, 2015
    Inventors: John David Imig, William B. Campbell, John Russell Falck
  • Epoxyeicosatrienoic acid analogs and methods of making and using the same
    Patent number: 9127027
    Abstract: Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of making and using the compounds and compositions are further described.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: September 8, 2015
    Assignees: The Medical College of Wisconsin, Inc., The Board of Regents of the University of Texas System
    Inventors: John David Imig, William B. Campbell, John Russell Falck
  • EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20140113884
    Abstract: Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of making and using the compounds and compositions are further described.
    Type: Application
    Filed: April 4, 2012
    Publication date: April 24, 2014
    Inventors: John David Imig, William B. Campell, John Russell Falck