Patents by Inventor John S. Abrams

John S. Abrams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5
    Patent number: 6451982
    Abstract: A monoclonal antibody is provided which specifically binds to human interleukin-5. Also provided are a hybridoma which produces the monoclonal antibody; complementary DNAs which encode the heavy and light chain variable regions of the monoclonal antibody and CDRs therefrom; humanized monoclonal antibodies; and pharmaceutical compositions comprising the monoclonal antibody or anti-idiotypic antibodies directed against it, humanized monoclonal antibodies, binding fragments, binding compositions or single-chain binding proteins derived from the antibody and a physiologically acceptable carrier.
    Type: Grant
    Filed: March 28, 2000
    Date of Patent: September 17, 2002
    Assignee: Schering Corporation
    Inventors: Chuan-Chu Chou, Nicholas J. Murgolo, John S. Abrams, Chung-Her Jenh, Mary E. Petro, Jon E. Silver, Stephen Tindall, William T. Windsor, Paul J. Zavodny
  • Cytokine antagonists
    Publication number: 20020068060
    Abstract: Antagonists of a cytokine signaling system have been found which exhibit favorable properties. In particular, antibody antagonists raised against the receptor are effective in blocking various signaling processes.
    Type: Application
    Filed: April 12, 2001
    Publication date: June 6, 2002
    Inventors: Johannes Eduard Maria Antonius Debets, John S. Abrams, Robert A. Kastelein, Anne O'Garra
  • Humanized monoclonal antibodies against human interleukin-5
    Patent number: 6056957
    Abstract: A monoclonal antibody is provided which specifically binds to human interleukin-5. Also provided are a hybridoma which produces the monoclonal antibody; complementary DNAs which encode the heavy and light chain variable regions of the monoclonal antibody and CDRs therefrom; humanized monoclonal antibodies; and pharmaceutical compositions comprising the monoclonal antibody or anti-idiotypic antibodies directed against it, humanized monoclonal antibodies, binding fragments, binding compositions or single-chain binding proteins derived from the antibody and a physiologically acceptable carrier.
    Type: Grant
    Filed: August 4, 1994
    Date of Patent: May 2, 2000
    Assignee: Schering Corporation
    Inventors: Chuan-Chu Chou, Nicholas J. Murgolo, John S. Abrams, Chung-Her Jenh, Mary E. Petro, Jon E. Silver, Stephen Tindall, William T. Windsor, Paul J. Zavodny
  • Monoclonal antibodies against human interleukin-4 and hybridomas producing the same
    Patent number: 5912136
    Abstract: Monoclonal antibodies are provided which are specific for human interleukin-4. Kits and methods are also provided for detecting, measuring and immunopurifying human interleukin-4.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: June 15, 1999
    Assignee: Schering Corporation
    Inventors: John S. Abrams, Isabelle Chretien, Frank D. Lee
  • Human interleukin immunopurification processes
    Patent number: 5700915
    Abstract: Monoclonal antibodies are provided which are specific for human interleukin-4. Kits and methods are also provided for detecting, measuring and immunopurifying human interleukin-4, and for blocking the biological activity of human interleukin-4.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: December 23, 1997
    Assignee: Schering Corporations
    Inventors: John S. Abrams, Isabelle Chretien, Frank D. Lee, Michael K. Pearce
  • Immunochemical assay for human granulocyte-macrophage colony stimulating factor
    Patent number: 5070013
    Abstract: Monoclonal antibodies and compositions thereof are provided for detecting, measuring, and immunopurifying human GM-CSF.
    Type: Grant
    Filed: May 31, 1988
    Date of Patent: December 3, 1991
    Assignee: Schering Corporation
    Inventors: John S. Abrams, Robert E. Van Dyke
  • Monoclonal antibodies against human interleukin-4 and hybridomas producing the same
    Patent number: 5041381
    Abstract: Monoclonal antibodies are provided which are specific for human interleukin-4. Kits and methods are also provided for detecting, measuring and immunopurifying human interleukin-4.
    Type: Grant
    Filed: October 26, 1987
    Date of Patent: August 20, 1991
    Assignee: Schering Corporation
    Inventors: John S. Abrams, Isabelle Chretien, Frank D. Lee
  • Human interleukin-4 peptides and conjugates thereof
    Patent number: 5013824
    Abstract: Peptides derived from human interleukin-4 are provided comprising from 6 to 40 amino acids. Conjugates of the peptides and carriers are also provided for the production of polyclonal and/or monoclonal antisera to human interleukin-4.
    Type: Grant
    Filed: September 19, 1986
    Date of Patent: May 7, 1991
    Assignee: Schering Corporation
    Inventors: John S. Abrams, Takashi Yokota, Frank Lee, Ken-ichi Arai