Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

Abstract: A method of communicating frames of management information includes loading a frame of management information from one of a plurality of stations into a respective one of a plurality of buffers. Whether the frame contains more than a predetermined number of bytes is determined. If an end of the frame is loaded into the respective one of the buffers, then a frame presence flag associated with said one of the plurality of stations is set. A request signal is transmitted to a station management module if the frame contains more than the predetermined number of bytes or if the buffer already contains management information associated with a previously loaded frame. The plurality of stations is polled to determine whether respective frame presence flags have been set.