Abstract: Disclosed is a cell expressing a modified CD3 subunit chain or a cell expressing a modified non-CD3 subunit chain comprising one or more of: (a) at least one Immuno-receptor Tyrosine-based Activation Motif (ITAM) deletion; or (b) at least one exogenous intracellular hematopoietic cell signaling domain; and (c) at least one modified ITAM comprising an amino acid sequence of Formula I. Related populations of cells, pharmaceutical compositions, methods of making the cells, methods of treating or preventing a condition in a subject, and methods of enhancing an antigen-specific immune response in a subject are also disclosed.

Abstract: 11-ether derivatives of erythromycin, and corresponding 9-(optionally substituted)-amino, 9-imino, and 9-(optionally substituted)-oxime derivatives are novel antibacterially active compounds, and can be prepared by alkylation of the 11-hydroxy group under mild conditions.

Abstract: The compounds of the formula (I): ##STR1## and salts and esters thereof wherein R.sub.1 is a hydrogen atom or a lower alkyl, aryl or aralkyl group, R.sub.2 and R.sub.3 are independently hydrogen, aryl, aralkyl, lower alkyl or substituted lower alkyl, or R.sub.3 is joined to R.sub.1 to form a 5- or 6- membered ring and X is S, SO or SO.sub.2 ; have been found to be .beta.-lactamase inhibitors and antibacterial agents. Their preparation and use is described.

Abstract: The compounds of the formula (I): ##STR1## and pharmaceutically acceptable salts and in-vivo hydrolysable esters thereof wherein X is a sulphur atom or SO or SO.sub.2 group and R is a hydrogen atom or an alkyl group of 1 to 6 carbon atoms have been found to be .beta.-lactamase inhibitors and antibacterial agents. Their preparation and use is described.

Abstract: A heat sensing cable is provided for use in an alarm and/or fire extinguishing system, which is capable of responding to the presence of fire, or excessive heat, and to sound an alarm, actuate fire extinguishing sprinkling equipment, operate other fire extinguishing means, or to perform other emergency functions. The heat sensing cable of the invention comprises two or more multi-strand single conductor plastic coated insulated wires twisted together in a spiral manner, and which are placed under tension when in use. Each insulated wire in the multi-conductor heat sensing cable of the invention consists of a single multi-strand conductor of low electrical resistance, formed of copper or other suitable conductive material, and having any particular gage to suit any particular application.

Abstract: An electrically energized fire and/or intrusion detection system is provided which includes an elongated electrically energized heat sensing element, and which also includes a plurality of spring-biased switching devices mechanically coupled to the heat sensing element to respond to tension variations therein to provide predetermined control effects, such as initiating alarms and/or activating appropriate fire suppression devices.