Patents by Inventor John S. Emtage

John S. Emtage has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4816397
    Abstract: Multichain polypeptides or proteins and processes for their production in cells of host organisms which have been transformed by recombinant DNA techniques. According to a first aspect of the present invention, there is provided a process for producing a heterologous multichain polypeptide or protein in a single host cell, which comprises transforming the host cell with DNA sequences coding for each of the polypeptide chains and expressing said polypeptide chains in said transformed host cell. According to another aspect of the present invention there is provided as a product of recombinant DNA technology an Ig heavy or light chain or fragment thereof having an intact variable domain. The invention also provides a process for increasing the level of protein expression in a transformed host cell and vectors and transformed host cells for use in the processes.
    Type: Grant
    Filed: November 14, 1984
    Date of Patent: March 28, 1989
    Assignee: Celltech, Limited
    Inventors: Michael A. Boss, John H. Kenten, John S. Emtage, Clive R. Wood
  • Patent number: 4357421
    Abstract: A process for the production of a synthetic gene for an influenza haemagglutinin which comprises:(a) subjecting isolated vRNA to the action of reverse transcriptase to produce a double-stranded RNA/DNA hybrid;(b) digesting the RNA component of the hybrid;(c) treating the residual DNA component of the hybrid to produce a double-stranded DNA molecule having one "hairpin" end; and(d) treating the "hairpin" structure with a single-strand specific nuclease to produce a bimolecular double-stranded copy of the vRNA.
    Type: Grant
    Filed: March 24, 1980
    Date of Patent: November 2, 1982
    Assignee: G. D. Searle & Co.
    Inventors: John S. Emtage, Norman H. Carey
  • Patent number: 4349629
    Abstract: A plasmid having an insertion site for a eukaryotic DNA fragment adjacent to a bacterial promoter and downstream from a prokaryotic ribosome binding site and initiator codon such that the bacterial promoter controls transcription and translation of an inserted DNA fragment is disclosed.The production and use of such plasmids is also disclosed.In general terms, one aspect of the present invention relates to a series of plasmid vectors having the basic characteristic of a Hind III insertion site adjacent to a tryptophan promoter and also a gene for tetracycline resistance. The plasmid vectors are by virtue of the structure thereof ideally suited to receive at the Hind III site an inserted eukaryotic DNA fragment the transcription and translation of which is under the control of the tryptophan promotor.
    Type: Grant
    Filed: May 29, 1980
    Date of Patent: September 14, 1982
    Assignee: G.D. Searle & Co.
    Inventors: Norman H. Carey, John S. Emtage, William C. A. Tacon, Robert A. Hallewell