Abstract: Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.

Abstract: A secondary battery is provided for cycling between a charged and a discharged state, the secondary battery including a battery enclosure, an electrode assembly, carrier ions, a non-aqueous liquid electrolyte within the battery enclosure, and a set of electrode constraints. The set of electrode constraints includes a primary constraint system having first and second primary growth constraints and at least one primary connecting member, the first and second primary growth constraints separated from each other in the longitudinal direction, wherein the primary constraint array restrains growth of the electrode assembly in the longitudinal direction such that any increase in the Feret diameter of the electrode assembly in the longitudinal direction over 20 consecutive cycles of the secondary battery is less than 20%.

Abstract: The present disclosure relates generally to modulators of human glycolate oxidase enzyme and methods of use and manufacture thereof.

Abstract: Robotic technology has been applied in many aspects of human life and industries. Putting robots in service business such as waiter serving in a restaurant is very promising industry in the near future. A serving robot is designed on the size and appearance requirement at local restaurants. The serving robot is programmed to come to a specific table by mapping data. The robot uses the multiple sensors, laser technology and mapping technology to move to the desired table position and returns to the service counter after completing the task like delivery of the food or other items. Some other robots required a QR code to be placed on the ceiling or a corner for the robot to move from table to tables, where our robot does not require a QR code to be placed on a ceiling or to a corner to move around autonomously. The robot is the ultimate helper that every restaurant owner needs for different states, according to settings.

Abstract: Disclosed herein are methods and systems for cross-web headless transactions. One method comprises in response to an interaction with a commerce object of a media element, retrieving a user identifier and metadata associated with a product depicted within the media element, the metadata indicating at least an attribute of the product, the media element displaying a graphical element indicating at least one attribute of the product retrieved from the metadata; retrieving payment data and a purchase preference based on the retrieved user identifier and metadata, the purchase preference being extracted from at least one previously completed purchase associated with the user identifier; generating a message containing transaction attributes corresponding to the payment data and the purchase preference; and transmitting the message to a server hosting the media element, wherein the message initiates a checkout process using at least one of the transaction attributes.

Abstract: The inventors have discovered that both soluble erythropoietin-binding protein and antibodies against the erythropoietin-binding protein, when they are administered to a mammal along with erythropoietin (Epo), prevent or reduce the blood pressure increase normally caused by erythropoietin, while not affecting the hematocrit increase that is the purpose of Epo treatment. The invention provides a method of treating anemia in a mammal involving: administering erythropoietin (Epo) to the mammal; and administering to the mammal an agent selected from a soluble Epo-binding protein (Epo-bp), a recognition protein that binds Epo receptor on an extracellular soluble portion of the Epo receptor, and a combination thereof. The invention also provides a method of reducing hypertension in a mammal receiving Epo, and pharmaceutical compositions containing a soluble Epo-bp and/or a recognition protein that binds Epo receptor on an extracellular soluble portion of the Epo receptor.

Abstract: The inventors have discovered that both soluble erythropoietin-binding protein and antibodies against the erythropoietin-binding protein, when they are administered to a mammal along with erythropoietin (Epo), prevent or reduce the blood pressure increase normally caused by erythropoietin, while not affecting the hematocrit increase that is the purpose of Epo treatment. The invention provides a method of treating anemia in a mammal involving: administering erythropoietin (Epo) to the mammal; and administering to the mammal an agent selected from a soluble Epo-binding protein (Epo-bp), a recognition protein that binds Epo receptor on an extracellular soluble portion of the Epo receptor, and a combination thereof. The invention also provides a method of reducing hypertension in a mammal receiving Epo, and pharmaceutical compositions containing a soluble Epo-bp and/or a recognition protein that binds Epo receptor on an extracellular soluble portion of the Epo receptor.

Abstract: The inventors have discovered that both soluble erythropoietin-binding protein and antibodies against the erythropoietin-binding protein, when they are administered to a mammal along with erythropoietin (Epo), prevent or reduce the blood pressure increase normally caused by erythropoietin, while not affecting the hematocrit increase that is the purpose of Epo treatment. The invention provides a method of treating anemia in a mammal involving: administering erythropoietin (Epo) to the mammal; and administering to the mammal an agent selected from a soluble Epo-binding protein (Epo-bp), a recognition protein that binds Epo receptor on an extracellular soluble portion of the Epo receptor, and a combination thereof. The invention also provides a method of reducing hypertension in a mammal receiving Epo, and pharmaceutical compositions containing a soluble Epo-bp and/or a recognition protein that binds Epo receptor on an extracellular soluble portion of the Epo receptor.

Abstract: The inventors have discovered that both soluble erythropoietin-binding protein and antibodies against the erythropoietin-binding protein, when they are administered to a mammal along with erythropoietin (Epo), prevent or reduce the blood pressure increase normally caused by erythropoietin, while not affecting the hematocrit increase that is the purpose of Epo treatment. The invention provides a method of treating anemia in a mammal involving: administering erythropoietin (Epo) to the mammal; and administering to the mammal an agent selected from a soluble Epo-binding protein (Epo-bp), a recognition protein that binds Epo receptor on an extracellular soluble portion of the Epo receptor, and a combination thereof. The invention also provides a method of reducing hypertension in a mammal receiving Epo, and pharmaceutical compositions containing a soluble Epo-bp and/or a recognition protein that binds Epo receptor on an extracellular soluble portion of the Epo receptor.

Abstract: Using the nontoxic PA protein from B. anthracis, a method and composition for use in inducing an immune response which is protective against anthrax in subjects is described.

Abstract: Using nucleic acids encoding mutant SEA and SEB exotoxins from Staphylococcus aureus, compositions and methods for use in inducing an immune response which is protective against staphylococcal aureus intoxication in subjects is described.

Abstract: Apparatus and methods are provided. At least one clamping finger of a movable tray of a compact disc printer pushes against an outer periphery of a compact disc disposed on a surface of the tray to clamp the compact disc between the clamping finger and a pair of studs that protrude from the surface of the tray and engage a periphery of a hole passing through a center of the compact disc. A carriage of the printer for moving an ink jet cartridge attached thereto across the compact disc to deposit an image on the compact disc may include a sensor. The sensor can be used to determine the presence of a compact disc on the tray, whether the compact disc is clamped to the tray, and a dimension of the compact disc, and to perform a calibration method.

Abstract: The invention is based on the development of several sensitive and simple methods for detecting erythropoietin and the erythropoietin receptor and associated antibodies. The methods and reagents are useful for differential diagnosis in Epo and EpoR related clinical problems. Methods and kits for simultaneous measurement of erythropoietin and erythropoietin receptor in a biological sample are described.

Abstract: A compact disc processing system allows for more efficient processing of compact discs. The system included a transporter mechanism that can grip and transport more than one compact disc at a time. As such, a second disc can be gripped while a first disc is being processed. This eliminates the need to wait for processing operations, such as recording or printing, to be completed prior to transporting the second disc. The system includes a gripping head with at least two vacuum controlled mechanisms for selectively gripping the discs. A disc organizer can be provided which includes trays that can be used to store discs for selective retrieval. The organizer eliminates the difficulty encountered in locating a processed disc from a large stack of discs.

Abstract: A hair extension device is provided wherein the hair extension device comprises: at least one comb; at least one bendable member having opposing ends, a first end being attached to the comb; and at least one length of hair attached to the second end of the bendable member wherein the end user forms a ponytail and the comb is attached onto the end user's existing hair adjacent to the ponytail and the bendable member is bent around the ponytail and shaped to provide for a plurality of hairstyles.

Abstract: The invention provides for a hair extension device and a method of manufacture of the hair extension device. The hair extension device includes at least one length of hair attached to a bendable wire and a comb attached to the wire. The method of manufacture provides the steps for attaching the hair to the formable wire and attaching the formable wire to a comb.

Abstract: The invention provides for a hair extension device and a method of manufacture of the hair extension device. The hair extension device includes at least one length of hair attached to a bendable wire and a comb attached to the wire. The method of manufacture provides the steps for attaching the hair to the formable wire and attaching the formable wire to a comb.

Abstract: Using the nontoxic PA protein from B. anthracis, a method and composition for use in inducing an immune response which is protective against anthrax in subjects is described.

Abstract: Using the nontoxic PA protein from B. anthracis, a method and composition for use in inducing an immune response which is protective against anthrax in subjects is described.