Abstract: A pump for pumping fluid includes a tube platen, a plunger, a bias member, inlet and outlet valves, an actuator mechanism, a position sensor, and a processor. The plunger is configured for actuation toward and away from the infusion-tube when the tube platen is disposed opposite to the plunger. The tube platen can hold an intravenous infusion tube. The bias member is configured to urge the plunger toward the tube platen.

Abstract: The present invention relates to efficient synthetic processes useful in the preparation of antiviral nucleosides, particularly uridine 4-oxime 5?-(2-methylpropanoate) {(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl]oxolan-2-yl}methyl 2-methylpropanoate and pharmaceutically acceptable salts, derivatives, tautomers, isomers, and prodrugs of, which may be active as antiviral agents, as well as compositions and methods thereof. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

Abstract: Methods are provided herein for assembling at least two nucleic acids using a sequence specific nuclease agent (e.g., a gRNA-Cas complex) to create end sequences having complementarity and subsequently assembling the overlapping complementary sequences. The nuclease agent (e.g., a gRNA-Cas complex) can create double strand breaks in dsDNA in order to create overlapping end sequences or can create nicks on each strand to produce complementary overhanging end sequences. Assembly using the method described herein can assemble any nucleic acids having overlapping sequences or can use a joiner oligo to assemble sequences without complementary ends.

Abstract: The present disclosure provides MTR kinase polypeptides having improved properties as compared to a naturally occurring wild-type MTR kinase polypeptide including the capability of phosphorylating D-ribose and 5?-D-isobutyrylribose to give alpha-D-ribose-1-phosphate and alpha 5?-D-isobutyrylribose-1-phosphate. Also provided are polynucleotides encoding the MTR kinase polypeptides, host cells capable of expressing the MTR kinase polypeptides, and methods of using the MTR kinase polypeptides to synthesize alpha-D-ribose-1-phosphate and alpha 5?-D-isobutyrylribose-1-phosphate.

Abstract: An imaging system and a method of imaging are provided. The imaging system includes a single optics module configured for focusing light reflected or emanated from a dynamic scene in the infrared spectrum and a synchronous focal plane array for receiving the focused light and acquiring infrared images having a high spatial resolution and a low temporal resolution from the received focused light. The imaging system further includes an asynchronous neuromorphic vision system configured for receiving the focused light and acquiring neuromorphic event data having a high temporal resolution, and a read-out integrated circuit (ROIC) configured to readout both the infrared images and event data.

Abstract: Redundant electrochemical systems and methods for vehicles are described. The systems include a first electrochemical device located at a first position on the vehicle wherein the first electrochemical device is configured to generate at least one of inert gas, oxygen, and electrical power and a second electrochemical device located at a second position on the vehicle wherein the second electrochemical device is configured to generate at least one of inert gas, oxygen, and electrical power. The first electrochemical device is configured to operate in a first mode during normal operation of the vehicle and a second mode when the second electrochemical device fails, wherein in the second mode, the first electrochemical device provides the at least one of inert gas, oxygen, and electrical power for at least one vehicle critical system of the vehicle.

Abstract: An imaging system and a method of imaging are provided. The imaging system includes a single optics module configured for focusing light reflected or emanated from a dynamic scene in the infrared spectrum and a synchronous focal plane array for receiving the focused light and acquiring infrared images having a high spatial resolution and a low temporal resolution from the received focused light. The imaging system further includes an asynchronous neuromorphic vision system configured for receiving the focused light and acquiring neuromorphic event data having a high temporal resolution, and a read-out integrated circuit (ROIC) configured to readout both the infrared images and event data.

Abstract: Redundant electrochemical systems and methods for vehicles are described. The systems include a first electrochemical device located at a first position on the vehicle wherein the first electrochemical device is configured to generate at least one of inert gas, oxygen, and electrical power and a second electrochemical device located at a second position on the vehicle wherein the second electrochemical device is configured to generate at least one of inert gas, oxygen, and electrical power. The first electrochemical device is configured to operate in a first mode during normal operation of the vehicle and a second mode when the second electrochemical device fails, wherein in the second mode, the first electrochemical device provides the at least one of inert gas, oxygen, and electrical power for at least one vehicle critical system of the vehicle.

Abstract: A system is disclosed for aircraft life support and generating inert gas. The system includes an electrochemical cell with a cathode and an anode separated by a proton transfer medium. A cathode supply fluid flow path is between an air source and a cathode fluid flow path inlet, and an inerting gas flow path is in operative fluid communication with a cathode fluid flow path outlet and a protected space. An anode supply fluid flow path is between a water source and an anode fluid flow path inlet, and an oxygen gas flow path is in operative fluid communication with an anode fluid flow path outlet and an aircraft occupant breathing device. An electrical connection is between a power source and the electrochemical cell.

Abstract: A floor cleaning device (10) includes a housing (40) and a container (43) removably received by the housing. A suction nozzle (18, 18?, 18?) is fluidly connected with the container and with a suction source (52) when the container is received by the housing. A filter (114) is selectively fluidly connected with the container and with the suction source. A float (170) selectively closes the fluid connection of the filter with the container. The filter and the float may be removable as a unit (42) from the cleaning device. The nozzle may be removable, allowing an appropriate nozzle to be selected according to the type of floor surface to be cleaned.

Abstract: An upright vacuum cleaner includes a nozzle base having a main suction opening formed in an underside thereof. A housing is hingedly connected to the nozzle base. The housing includes a dirt separation chamber and a dirt receptacle for receiving dirt and dust separated by the dirt separation chamber. A conduit connects the nozzle base to the housing. A suction source is located in one of the housing and the nozzle base. The suction source is in fluid communication with the dirt separation chamber. A generally conically shaped filter extends into the dirt separation chamber along a longitudinal axis of the dirt separation chamber.

Abstract: A floor cleaning device (10) includes a housing (40) and a container (43) removably received by the housing. A suction nozzle (18, 18?, 18?) is fluidly connected with the container and with a suction source (52) when the container is received by the housing. A filter (114) is selectively fluidly connected with the container and with the suction source. A float (170) selectively closes the fluid connection of the filter with the container. The filter and the float may be removable as a unit (42) from the cleaning device. The nozzle may be removable, allowing an appropriate nozzle to be selected according to the type of floor surface to be cleaned.

Abstract: The present invention provides a ligating band dispenser that is mounted on the distal end of an endoscope. The ligator is configured to deliver multiple ligating bands to a plurality of internal sites in a patient. The ligating bands are carried on a tubular band carrier member that is retractable relative to the distal end of the endoscope in order to preserve visibility through the endoscope during navigation, then extendable to define a suction chamber for tissue aspiration during band delivery. A tubular band driver member is slidable over the band carrier member and engages bands individually to push them off the distal end of the band carrier and onto a selected treatment site. A single-hand operated control handle for selectively operating the extension of the band carrier and movement of the band driver to release a band is also provided and is slidably and removably mounted to the endoscope shaft.

Abstract: A vacuum cleaner has a suction nozzle, a housing connected to the suction nozzle and a suction fan and motor assembly mounted to the housing. A dirt collecting receptacle is mounted to the housing and is in communication with the suction nozzle and suction fan and motor assembly. A support plate is pivotally mounted to the housing and selectively holds a cleaning sheet for collecting dust and debris from a surface to be cleaned.

Abstract: A bagless canister vacuum cleaner includes a selectively removable dirt cup, and an airstream flows rotationally through the dirt cup between an interior wall of the dirt cup and a filter assembly selectively mounted in the dirt cup so that entrained contaminants are separated from the airstream flowing through the dirt cup and collected by the dirt cup. The filter lies substantially parallel to the support surface on which the vacuum cleaner is supported. A cover member is connected to the main housing, and the cover member is selectively movable to and held in an operative position in covering relation with an open first end of a dirt cup. The main housing defines a base conformed to self-support the main housing on a support surface with the dirt cup arranged with its open first end at a higher elevation than its closed second end. The removable dirt cup includes a handle adapted for being held by a user, and the dirt cup defines or includes a spout to facilitate emptying dirt therefrom.

Abstract: A bagless canister vacuum cleaner includes a selectively removable dirt cup, and an airstream flows rotationally through the dirt cup between an interior wall of the dirt cup and a filter assembly selectively mounted in the dirt cup so that entrained contaminants are separated from the airstream flowing through the dirt cup and collected by the dirt cup. The filter lies substantially parallel to the support surface on which the vacuum cleaner is supported. A cover member is connected to the main housing, and the cover member is selectively movable to and held in an operative position in covering relation with an open first end of a dirt cup. The main housing defines a base conformed to self-support the main housing on a support surface with the dirt cup arranged with its open first end at a higher elevation than its closed second end. The removable dirt cup includes a handle adapted for being held by a user, and the dirt cup defines or includes a spout to facilitate emptying dirt therefrom.

Abstract: An upright vacuum cleaner includes a floor nozzle having a suction inlet and a handle. A housing has a first portion connected to the floor nozzle, a second portion connected to the handle and defines a cavity and at least one chamber. A dirt cup assembly is releasably connected to the housing and is at least partially received by the cavity. The dirt cup assembly defines a cyclonic airflow chamber and includes a wall. An inlet duct is defined on the dirt cup assembly wall and a filter assembly is removably positioned in the dirt cup assembly.

Abstract: A floor nozzle for a vacuum cleaner includes a central housing. A left nozzle head is movably secured to the central housing. A right nozzle head is movably secured to the central housing, wherein a portion of the left nozzle head and a portion of the right nozzle head extend into the central housing and move around a vertical axis passing through the central housing.

Abstract: An upright vacuum cleaner includes a nozzle base having a main suction opening formed in an underside thereof. A housing is hingedly connected to the nozzle base. The housing includes a dirt separation chamber and a dirt receptacle for receiving dirt and dust separated by the dirt separation chamber. A conduit connects the nozzle base to the housing. A suction source is located in one of the housing and the nozzle base. The suction source is in fluid communication with the dirt separation chamber. A generally conically shaped filter extends into the dirt separation chamber along a longitudinal axis of the dirt separation chamber.