Abstract: A process is disclosed for preparing arylpropionic acids of formula Ar--CH(CH.sub.3)--COOH, by reacting an aryl Grignard reagent with a metal pyruvate or with a pyruvamide, to form a hydroxy acid of formula Ar--C(OH)(CH.sub.3)--COOH or its amide, and converting the acid or amide to the product.

Abstract: Disclosed is a process for increasing the proportion of a desired enantiomer of a 2-arylpropionic acid which comprises heating at a temperature of at least 80.degree. C. a mixture comprising an inert liquid organic diluent and a salt of the 2-arylpropionic acid with an enantiomer of a chiral organic nitrogenous base, the base and the diluent being such that the salt of the racemic acid has a solubility of 0.1 to 10% w/v in the diluent at the operating temperature and in which process a proportion of the salt is undissolved in the diluent, whereby a proportion of one optical isomer of the acid component of the salt is converted into its enantiomer, and collecting the salt of which the acid component has an increased proportion of that enantiomer.

Abstract: A process is disclosed for preparing arylpropionic acids of formula Ar--CH(CH.sub.3)--COOH, by reacting an aryl Grignard reagent with a metal pyruvate or with a pyruvamide, to form a hydroxy acid of formula Ar--C(OH)(CH.sub.3)--COOH or its amide, and converting the acid or amide to the product.

Abstract: New compounds which are 2-(halogenated-hydroxy-substituted-4-biphenylyl)propionic acids, having, inter alia, anti-inflammatory activity.

Abstract: 2-[4-(2-Fluorophenoxy)phenyl]propionic acid and salts, esters, the amide and the alcohol derived therefrom, useful as anti-inflammatory agents, and their preparation.

Abstract: Novel trihalosubstituted biphenylyl propionic and acetic acids and their derivatives are described together with processes for their preparation and composition of them. They are useful as anti-inflammatory agents.

Abstract: Therapeutic compositions comprising 2-(hydroxy-substituted-4-biphenylyl)propionic acids and methods of treatment of inflammation, pain, fever and preventing blood platelet aggregation with these compounds.

Abstract: Novel substituted aromatic hydrocarbons and ethers, and pharmaceutical compositions containing them, are described. They have pharmaceutical activity, e.g. as anti-inflammatory agents.

Abstract: New compounds are described that are 2-(hydroxy substituted-4-biphenylyl)propionic acids. Processes of making and using them and pharmaceutical compositions containing them are also described. The compounds have, inter alia, antiinflammatory activity.

Abstract: A novel process for making aryl propionic acids is described. It comprises reaction of a Grignard compound, obtained from an aryl bromide and magnesium, with a lithium, sodium, magnesium or calcium salt of 2-bromopropionic acid, followed by acidification.