Patents by Inventor John S. Wesolowski, Jr.

John S. Wesolowski, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of using Fc-cytokine fusion proteins
    Patent number: 8043608
    Abstract: Disclosed herein are methods and compositions for enhancing the immunogenicity of a preselected protein or peptide antigen in a mammal. Immunogenicity is enhanced by fusing the preselected antigen to an immunoglobulin heavy chain constant region to produce an Fc-antigen fusion protein. The Fc-antigen fusion proteins bind Fc receptors on the surface of antigen presenting cells, thereby targeting the antigen to the antigen presenting cells in the mammal. In addition, disclosed is a family of adjuvants, for example, an Fc-adjuvant fusion protein, for use in combination with the Fc-antigen fusion proteins to enhance or modulate a particular immune response against the preselected antigen.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: October 25, 2011
    Assignee: Merck Patent GmbH
    Inventors: Stephen D. Gillies, Kin-Ming Lo, John S. Wesolowski, Jr.
  • Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
    Patent number: 7955590
    Abstract: Disclosed herein are methods and compositions for enhancing the immunogenicity of a preselected protein or peptide antigen in a mammal. Immunogenicity is enhanced by fusing the preselected antigen to an immunoglobulin heavy chain constant region to produce an Fc-antigen fusion protein. The Fc-antigen fusion proteins bind Fc receptors on the surface of antigen presenting cells, thereby targeting the antigen to the antigen presenting cells in the mammal. In addition, disclosed is a family of adjuvants, for example, an Fc-adjuvant fusion protein, for use in combination with the Fc-antigen fusion proteins to enhance or modulate a particular immune response against the preselected antigen.
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: June 7, 2011
    Assignee: Merck Patent GmbH
    Inventors: Stephen D. Gillies, Kin-Ming Lo, John S. Wesolowski, Jr.
  • Methods of using Fc-Cytokine fusion proteins
    Publication number: 20100068175
    Abstract: Disclosed herein are methods and compositions for enhancing the immunogenicity of a preselected protein or peptide antigen in a mammal. Immunogenicity is enhanced by fusing the preselected antigen to an immunoglobulin heavy chain constant region to produce an Fc-antigen fusion protein. The Fc-antigen fusion proteins bind Fc receptors on the surface of antigen presenting cells, thereby targeting the antigen to the antigen presenting cells in the mammal. In addition, disclosed is a family of adjuvants, for example, an Fc-adjuvant fusion protein, for use in combination with the Fc-antigen fusion proteins to enhance or modulate a particular immune response against the preselected antigen.
    Type: Application
    Filed: March 25, 2009
    Publication date: March 18, 2010
    Inventors: Stephen D. Gillies, Kin Ming Lo, John S. Wesolowski, JR.
  • Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
    Patent number: 7067110
    Abstract: Disclosed herein are methods and compositions for enhancing the immunogenicity of a preselected protein or peptide antigen in a mammal. Immunogenicity is enhanced by fusing the preselected antigen to an immunoglobulin heavy chain constant region to produce an Fc-antigen fusion protein. The Fc-antigen fusion proteins bind Fc receptors on the surface of antigen presenting cells, thereby targeting the antigen to the antigen presenting cells in the mammal. In addition, disclosed is a family of adjuvants, for example, an Fc-adjuvant fusion protein, for use in combination with the Fc-antigen fusion proteins to enhance or modulate a particular immune response against the preselected antigen.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: June 27, 2006
    Assignee: EMD Lexigen Research Center Corp.
    Inventors: Stephen D. Gillies, Kin Ming Lo, John S. Wesolowski, Jr.