Patents by Inventor John Salogiannis

John Salogiannis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of promoting excitatory synapse formation with an anti-Ephexin5 phospho-Y361 antibody
    Patent number: 9541546
    Abstract: The invention provides methods of screening a compound that can increase spine/excitatory synapse formation and/or numbers. The compound is identified by contacting Ephexin5 with a test compound and selecting the compounds that inhibit Rho GEF activity of Ephexin5. Additionally, the invention also provides methods for increasing spine/excitatory synapse formation and/or numbers by contacting a neuron with an Ephexin5 inhibitor.
    Type: Grant
    Filed: February 5, 2015
    Date of Patent: January 10, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: John Salogiannis, Michael E. Greenberg, Seth S. Margolis
  • METHOD FOR DETERMINING ACTIVATORS OF EXCITATORY SYNAPSE FORMATION
    Publication number: 20150219630
    Abstract: The invention provides methods of screening a compound that can increase spine/excitatory synapse formation and/or numbers. The compound is identified by contacting Ephexin5 with a test compound and selecting the compounds that inhibit Rho GEF activity of Ephexin5. Additionally, the invention also provides methods for increasing spine/excitatory synapse formation and/or numbers by contacting a neuron with an Ephexin5 inhibitor.
    Type: Application
    Filed: February 5, 2015
    Publication date: August 6, 2015
    Inventors: John SALOGIANNIS, Michael E. GREENBERG, Seth S. MARGOLIS
  • Method for determining activators of excitatory synapse formation
    Patent number: 8980861
    Abstract: The invention provides methods of screening a compound that can increase spine/excitatory synapse formation and/or numbers. The compound is identified by contacting Ephexin5 with a test compound and selecting the compounds that inhibit Rho GEF activity of Ephexin5. Additionally, the invention also provides methods for increasing spine/excitatory synapse formation and/or numbers by contacting a neuron with an Ephexin5 inhibitor.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: March 17, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: John Salogiannis, Michael E. Greenberg, Seth S. Margolis
  • METHOD FOR DETERMINING ACTIVATORS OF EXCITATORY SYNAPSE FORMATION
    Publication number: 20130273076
    Abstract: The invention provides methods of screening a compound that can increase spine/excitatory synapse formation and/or numbers. The compound is identified by contacting Ephexin5 with a test compound and selecting the compounds that inhibit Rho GEF activity of Ephexin5. Additionally, the invention also provides methods for increasing spine/excitatory synapse formation and/or numbers by contacting a neuron with an Ephexin5 inhibitor.
    Type: Application
    Filed: October 25, 2011
    Publication date: October 17, 2013
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: John Salogiannis, Michael E. Greenberg, Seth S. Margolis