Abstract: A disposable valve assembly configured for use with an endoscope is disclosed. The disposable valve assembly may include a stem comprised of thermoplastic material, a spring stanchion configured to receive the stem and allow movement of the stem in an upward and downward position relative to the spring stanchion, a spring configured to contact that spring stanchion and the stem. In some embodiments, a lubricant is disposed on the stem, the spring stanchion and/or the spring. The disposable valve assembly may also include an antimicrobial agent disposed in the lubricant, or in the thermoplastic material and/or can be coated thereon. A method for manufacturing the disposable valve assemblies for use with an endoscope may include several steps.

Abstract: Provided is a fitting for a medical scoping device, the fitting comprising a body defining a longitudinal axis, the body having an interior having an opening to receive an endoscope along the longitudinal axis, the body having a cylindrical portion comprising protuberances being spaced apart and circumferentially arrayed with respect to one another and extending from the cylindrical portion, each of the protuberances having an outer edge to engage tissue.

Abstract: Provided is a fitting for a medical scoping device, the fitting comprising a body defining a longitudinal axis, the body having an interior having an opening to receive an endoscope along the longitudinal axis, the body having a cylindrical portion comprising protuberances being spaced apart and circumferentially arrayed with respect to one another and extending from the cylindrical portion, each of the protuberances having an outer edge to engage tissue.

Abstract: Provided is a fitting for a medical scoping device, the fitting comprising a body defining a longitudinal axis, the body having an interior having an opening to receive an endoscope along the longitudinal axis, the body having a cylindrical portion comprising protuberances being spaced apart and circumferentially arrayed with respect to one another and extending from the cylindrical portion, each of the protuberances having an outer edge to engage tissue, wherein optionally (i) the interior comprises a plurality of raised surfaces disposed thereon; and/or (ii) each protuberance having a bottom surface having a plurality of raised surfaces disposed thereon. Methods of making and using the fitting are also disclosed.

Abstract: A method is described for correlating microscopy images from a number of modalities in a sub diffraction resolution environment. The method may include receiving a number of datasets that may represent microscopy captures from a number of different modalities. The microscopy captures may contain feature markers that may be used to register a number of data points contained in a dataset with data points from another dataset. Upon registering the data points of the datasets, a combined dataset may be produced and a visual image of the combined dataset may be provided.

Abstract: A fixed wire dilatation catheter for treating the vasculature of a patient. The dilatation catheter includes an elongated member that has a distal end portion which can be elongated to puncture through blockages within the blood vessels. The dilatation catheter also includes an expandable device located along the elongated member at a location proximal the distal end portion of the elongated member.

Abstract: A method is described for correlating microscopy images from a number of modalities in a sub diffraction resolution environment. The method may include receiving a number of datasets that may represent microscopy captures from a number of different modalities. The microscopy captures may contain feature markers that may be used to register a number of data points contained in a dataset with data points from another dataset. Upon registering the data points of the datasets, a combined dataset may be produced and a visual image of the combined dataset may be provided.

Abstract: The invention is directed to a guidewire having a distal section with multiple distally tapered core segments with at least two contiguous distally tapering core segments in which the most distal tapered core segment preferably has a greater degree of taper than the proximally contiguous tapered core segment. The invention is also directed to an elongated intracorporeal device, preferably a guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal section of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that preferably is configured to produce a linear change in stiffness of the core over a longitudinal section of the device.

Abstract: The invention is directed to a guidewire having a distal section with multiple distally tapered core segments with at least two contiguous distally tapering core segments in which the most distal tapered core segment preferably has a greater degree of taper than the proximally contiguous tapered core segment. The invention is also directed to an elongated intracorporeal device, preferably a guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal section of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that preferably is configured to produce a linear change in stiffness of the core over a longitudinal section of the device.

Abstract: The invention is directed to a guidewire having a distal section with multiple distally tapered core segments with at least two contiguous distally tapering core segments in which the most distal tapered core segment preferably has a greater degree of taper than the proximally contiguous tapered core segment. The invention is also directed to an elongated intracorporeal device, preferably a guidewire or section thereof, that has a core member with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal section of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that preferably is configured to produce a linear change in stiffness of the core over a longitudinal section of the device.

Abstract: An occlusion system, method, and apparatus which treats an aneurysm in a primary vessel such as an intracranial vessel. Aneurysm types treatable by means of this invention include bulge (sometimes referred to as a true aneurysm), dissecting aneurysms in which the layers of vessel wall are partially delaminated, and what are referred to a “false” aneurysm defined by a relatively small opening in the parent vessel wall fluridically coupled to a bulb-shaped sac, also defined by the vessel wall. The system includes an occlusion device configured for deployment in the parent vessel that restricts fluid flow to the aneurysm. A patch on the device covers the neck of the aneurysm. The system includes a marker in a defined relationship with the patch, which allows for axial and rotational positioning of the device.

Abstract: The invention is directed to a guidewire having a distal section with multiple distally tapered core segments with at least two contiguous distally tapering core segments in which the most distal tapered core segment preferably has a greater degree of taper than the proximally contiguous tapered core segment. The invention is also directed to an elongated intracorporeal device, preferably a guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal section of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that preferably is configured to produce a linear change in stiffness of the core over a longitudinal section of the device.

Abstract: A guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal portion of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that is configured to produce a linear change in stiffness of the core over a longitudinal portion of the device. An embodiment has a plurality of radiopaque elements that may be intermittent, continuous or in the form of a helical ribbon for scaled measurement of intracorporeal structure under fluoroscopic imaging. Another embodiment has at least one layer of polymer over the distal end of the device.

Abstract: A guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal portion of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that is configured to produce a linear change in stiffness of the core over a longitudinal portion of the device. An embodiment has a plurality of radiopaque elements that may be intermittent, continuous or in the form of a helical ribbon for scaled measurement of intracorporeal structure under flouroscopic imaging. Another embodiment has at least one layer of polymer over the distal end of the device.

Abstract: A fixed wire dilatation catheter for treating the vasculature of a patient. The dilatation catheter includes an elongated member that has a distal end portion which can be elongated to puncture through blockages within the blood vessels. The dilatation catheter also includes an expandable device located along the elongated member at a location proximal the distal end portion of the elongated member.

Abstract: A guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal portion of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that is configured to produce a linear change in stiffness of the core over a longitudinal portion of the device. An embodiment has a plurality of radiopaque elements that may be intermittent, continuous or in the form of a helical ribbon for scaled measurement of intracorporeal structure under fluoroscopic imaging. Another embodiment has at least one layer of polymer over the distal end of the device.

Abstract: A guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal portion of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that is configured to produce a linear change in stiffness of the core over a longitudinal portion of the device. An embodiment has a plurality of radiopaque elements that may be intermittent, continuous or in the form of a helical ribbon for scaled measurement of intracorporeal structure under flouroscopic imaging. Another embodiment has at least one layer of polymer over the distal end of the device.