Abstract: The present invention is based on the finding that subanesthetic doses of N-methyl-D-aspartate (NMDA) receptor antagonists alleviate social interaction deficits associated with behavioral disorders, such as Smith-Magenis Syndrome (SMS). The invention therefore provides methods and compositions for treating SMS. Also provided are methods of selecting NMDA receptor agonists useful in alleviating social interaction deficits associated with such behavioral disorders.

Abstract: A system for use in automated intraocular lens metrology can include a wet cell having a wet cell base including one or more recesses, a wet cell lid, and an insert configured for placement within the wet cell base. The insert can include a first side, and a second side configured to removably engage with the first side. The insert can include one or more first components configured to align with the one or more recesses to inhibit rotation of the insert within the wet cell base, and one or more second components configured to constrain an intraocular lens (IOL) in a horizontal plane. The insert can be configured to hold the IOL between the first and second sides. The system can further include an assembly configured to removably engage with and reduce the conduction of heat through the wet cell.

Abstract: An automated apparatus for measuring characteristics of an intraocular lens is disclosed. The automated apparatus may include a first robotic assembly configured to place an intraocular lens into a lens holding assembly and a second robotic assembly configured to place the lens holding assembly in a lens carrier. The automated apparatus may also include a first automated station for filling the lens carrier with a solution and a second automated station for performing measurements on the intraocular lens carried by the lens carrier. Further, the automated apparatus may include a third automated station for removing the solution from the lens carrier. In addition, the automated apparatus may include a third robotic assembly configured to remove the lens holding assembly from the lens carrier and a fourth automated station configured to dry the intraocular lens.

Abstract: A method, a system, and a non-transitory computer-readable medium provides an interactive patient-level data visualization and analysis tool that illustrates a patient's health trajectory across multiple organ systems. Data from an electronic medical record system and one or more research databases are integrated into an analytics platform. A visualization tool plots the patient's health trajectory and overlays data from an entire user-defined disease cohort as a reference group to visualize a disease course of the patient compared to courses of other patients, with a same disease, selected by a user.

Abstract: A method of wagering includes the steps of developing an N×N grid based on selections from a bettor, the selections being based on different independent events conducted at different times; receiving a selection of at least one of the events; and displaying specific details of the selection. A non-transitory machine-readable storage medium, having encoded thereon program code, wherein, when the program code is executed by a machine, the machine implements the method is also provided. The method can be performed on any mobile computing device, computer, smart television, or other device properly equipped to perform and display such method.

Abstract: Batch de-identification of unstructured health care documents includes performing optical character recognition (OCR) upon a form-based document so as to produce an initial set of terms. Amongst the initial set of terms, initial specific terms are identified which contain protected information. Each of the identified initial specific terms are then replaced with synthetically generated corresponding terms. Subsequently, additional OCR is performed upon the form-based document so as to produce a new set of terms and new specific terms are identified amongst the new set of terms which are determined to contain protected information. Finally, the new specific terms are compared to the initial specific terms and the form-based document is then added to a repository of de-identified documents only if none of the new specific terms are equivalent to corresponding ones of the initial specific terms. But otherwise, the form-based document is flagged in error.

Abstract: Individual four-sided shaped modules used in an assembly for underground storage of storm water and other fluid storage needs. Modules are assembled into a resultant four-sided tiling shape for maximized structural strength and material use efficiency. Internal four-sided shaped modules are assembled and encased by external four-sided shaped modules. Internal adjacent modules are in direct fluid communications with one another through a channel-less chamber. Internal four-sided shaped modules drain into four-sided shaped modules chamber where fluid is either stored or drained. Assemblies include various top and side pieces along with access ports for entry into said assembly.

Abstract: Individual four-sided shaped modules used in an assembly for underground storage of storm water and other fluid storage needs. Modules are assembled into a resultant four-sided tiling shape for maximized structural strength and material use efficiency. Internal four-sided shaped modules are assembled and encased by external four-sided shaped modules. Internal adjacent modules are in direct fluid communications with one another through a channel-less chamber. Internal four-sided shaped modules drain into four-sided shaped modules chamber where fluid is either stored or drained. Assemblies include various top and side pieces along with access ports for entry into said assembly.

Abstract: A method for providing automatic placement of a lens in a cartridge is provided. The method includes seizing, by a nozzle head of a lifting tool, the lens from a pick position of a platform based on an air flow through the nozzle head and depositing, by the lifting tool, the lens at a delivery point in the cartridge by changing the air flow through the nozzle head. The method includes determining, by a processor coupled to the lifting tool, a location of a haptic of the lens with respect to a feature of the cartridge. The method includes adjusting, by the lifting tool, the haptic from the location to a target orientation on the cartridge when the location of the haptic is determined to be misaligned with the feature. The method can be implemented as an apparatus, a system, and/or a computer program product.

Abstract: A method of allocating a single wager into multiple parlay wagers, each including several different wagering events. Wagering events from the multiple parlay wagers are arranged in easily identifiable patterns that are viewed on a single two-dimensional parlay grid. The method includes the selection of wagering events from a list of wagering events or a bettor's betslip, the placement of a wagering event on a parlay grid betspace, re-arrangement of wagering events on the parlay grid, selection of two-dimensional parlay patterns, allocation of a single wager into multiple parlay wagers, displaying potential and actual payout calculations for each of the parlay wagers on a two-dimensional parlay betslip. The method can be performed on any mobile computing device, computer, smart television, or other device properly equipped to perform and display such method.

Abstract: A turbine with an associated shaftless electric generator includes a rotor and a stator; a mounting plate rotatable with the rotor and a void along a central axis of the rotor. A plurality of blades extend from the mounting plate. Adjustable bearings are interposed between the rotor and the stator, the adjustable bearings being configured to support the mounting plate and the plurality of blades. A threaded adjustor rod located in the void may be manipulated to adjust tension on the adjustable bearings.

Abstract: Batch de-identification of unstructured health care documents includes performing optical character recognition (OCR) upon a form-based document so as to produce an initial set of terms. Amongst the initial set of terms, initial specific terms are identified which contain protected information. Each of the identified initial specific terms are then replaced with synthetically generated corresponding terms. Subsequently, additional OCR is performed upon the form-based document so as to produce a new set of terms and new specific terms are identified amongst the new set of terms which are determined to contain protected information. Finally, the new specific terms are compared to the initial specific terms and the form-based document is then added to a repository of de-identified documents only if none of the new specific terms are equivalent to corresponding ones of the initial specific terms. But otherwise, the form-based document is flagged in error.

Abstract: A synthetic generation of healthcare documents for use in training a classifier is described herein. Initially, a multiplicity of electronic forms are received in memory of a host computing system and data extracted from a specific common field located in each of the forms. A statistical metric is then computed for the specific common field a value synthetically generated for the specific common field according to the computed statistical metric. Finally, the synthetically generated value is inserted into the specific common field of a training version of the electronic forms and the training version of the electronic forms persisted as part of a training data set for a classifier adapted to classify the multiplicity of electronic forms.

Abstract: A turbine with an associated shaftless electric generator is disclosed. The generator includes a rotor and a stator; a mounting plate rotatable with the rotor and a void along a central axis of the rotor. A plurality of blades extend from the mounting plate. Adjustable bearings are interposed between the rotor and the stator, the adjustable bearings being configured to support the mounting plate and the plurality of blades. A threaded adjustor rod located in the void may be manipulated to adjust tension on the adjustable bearings.

Abstract: A dispensing closure system includes an upper closure portion and a lower closure portion including an axial flow conduit and a vent conduit. The upper closure portion is axially movable relative to lower closure portion between shipping and dispensing positions. A seal is disposed on the lower closure portion over the flow and vent conduits. A peripheral spacing strip is removably secured to the upper closure portion and engages with either the lower closure or the outside of the container to prevent movement. A piercing probe includes piercing elements in alignment with the flow and vent conduits for piercing the seal. In the shipping position, the piercing elements are spaced from the seal. However, when the spacing strip is removed and the upper closure portion is axially moved to the dispensing position, the piercing elements pierce the seal to open the flow conduit and the vent conduit.

Abstract: The invention relates to novel compounds of the general formula (I), with Het-2 being an optionally substituted bicyclic heteroaryl of the formula pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the use as ferroportin inhibitors, more particularly for the use in the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.

Abstract: A dispensing closure system includes an upper closure portion and a lower closure portion including an axial flow conduit and a vent conduit. The upper closure portion is axially movable relative to lower closure portion between shipping and dispensing positions. A seal is disposed on the lower closure portion over the flow and vent conduits. A peripheral spacing strip is removably secured to the upper closure portion and engages with either the lower closure or the outside of the container to prevent movement. A piercing probe includes piercing elements in alignment with the flow and vent conduits for piercing the seal. In the shipping position, the piercing elements are spaced from the seal. However, when the spacing strip is removed and the upper closure portion is axially moved to the dispensing position, the piercing elements pierce the seal to open the flow conduit and the vent conduit.

Abstract: The present invention is based on the finding that subanesthetic doses of N-methyl-D-aspartate (NMDA) receptor antagonists alleviate social interaction deficits associated with behavioral disorders, such as Smith-Magenis Syndrome (SMS). The invention therefore provides methods and compositions for treating SMS. Also provided are methods of selecting NMDA receptor agonists useful in alleviating social interaction deficits associated with such behavioral disorders.

Abstract: Disclosed herein are various embodiments relating to devices, systems and methods relating to the mounting and inflating of tires for use in automotive applications. There is a need in the art for improved devices, systems and methods for tire mounting and inflation, so as to allow a user to prepare racing tires without mounting on a rim.

Abstract: A dispensing closure system includes an upper closure portion and a lower closure portion including an axial flow conduit and a vent conduit. The upper closure portion is axially movable relative to lower closure portion between shipping and dispensing positions. A seal is disposed on the lower closure portion over the flow and vent conduits. A peripheral spacing strip is removably secured to the upper closure portion and engages with either the lower closure or the outside of the container to prevent movement. A piercing probe includes piercing elements in alignment with the flow and vent conduits for piercing the seal. In the shipping position, the piercing elements are spaced from the seal. However, when the spacing strip is removed and the upper closure portion is axially moved to the dispensing position, the piercing elements pierce the seal to open the flow conduit and the vent conduit.