Abstract: Apparatus (10) for the preparation of aerated drinks, comprising: an aerator stage (20) comprising: a removable aerator bottle (30) defining a chamber (32) for receiving a liquid to be aerated; an aerator bottle interface (40) operative to engage the removable aerator bottle (30) and seal the chamber (32) thereof; a gas inlet line (60) operative to fluidly connect a gas source (50) to the aerator bottle interface (40); and a gas supply mechanism (70) for controlling supply of gas from the gas source (50) to the aerator bottle interface (40) via the gas inlet line (60); characterised by: an aerated liquid dispenser outlet (110); a liquid outlet line (120) operative to fluidly connect the aerator bottle interface (40) to the aerated liquid dispenser outlet (110) to allow aerated liquid to flow from the chamber (32) of the removable aerator bottle (30) to the aerated liquid dispenser outlet (110); and a liquid flow controller (130) for controlling discharge of aerated liquid from the removable aerator bottle (30

Abstract: A method, apparatus, and system for testing a performance of a device under different load conditions is provided. A load profile to be applied to the device by a linkage system that includes a support member, a load member, and an actuating member is identified. A value for a setting of an actuator of the actuating member is determined based on the load profile. The actuator is operated with the setting having the value determined such that a load is applied to a control surface of the device via the load member. The load applied to the control surface is determined by both the value for the setting of the actuator and a geometry of the linkage system.

Abstract: Pharmaceutical ophthalmic compositions are described, the compositions consisting essentially of a therapeutically effective quantity of an anti-bacterial agent (such as moxifloxacin), a therapeutically effective quantity of an anti-inflammatory agent (such as prednisolone), a combination of at least two solubilizing and suspending agents (of which one is a non-ionic polyoxyethlene-polyoxypropylene block copolymer), and a carrier. Methods for fabricating the compositions and using them are also described.

Abstract: The present invention is based on the finding that subanesthetic doses of N-methyl-D-aspartate (NMDA) receptor antagonists alleviate social interaction deficits associated with behavioral disorders, such as Smith-Magenis Syndrome (SMS). The invention therefore provides methods and compositions for treating SMS. Also provided are methods of selecting NMDA receptor agonists useful in alleviating social interaction deficits associated with such behavioral disorders.

Abstract: The present invention relates to antibodies and antigen binding fragments thereof which bind to the human CD70 protein with high affinity and display potent inhibition of tumour cell growth.

Abstract: The present disclosure generally provides for advanced single camera video conferencing systems and methods related thereto. The advanced single camera video conferencing system features a hybrid optical/digital camera, herein a camera device, having a controller that is configured to execute one or more of the methods set forth herein. In one embodiment, a method includes optically framing a first portion of a video conferencing environment to provide an actual field-of-view, digitally framing a second portion of the video conferencing environment to provide an apparent field-of-view that is encompassed within the actual field-of-view, generating a video stream of the apparent field-of-view, surveying the actual field-of-view to generate survey data, and detecting changes in the survey data over time. The method may be performed using a single camera device using a single image sensor.

Abstract: Described herein is a transport system and method of transporting objects including people between locations. The description also relates to urban and public transport systems for moving large numbers of people and freight or objects between locations. The description also relates to transport systems based on cable and rail elements and moving therebetween. Also described are junction mechanisms, switching and control systems.

Abstract: Disclosed herein are various embodiments relating to devices, systems and methods relating to the mounting and inflating of tires for use in automotive applications. There is a need in the art for improved devices, systems and methods for tire mounting and inflation, so as to allow a user to prepare racing tires without mounting on a rim.

Abstract: Methods, devices and program products are provided for utilizing one or more processors to receive a request from a client device for a network responsive resource. The network responsive resource includes a substitute scripted component. The methods, devices and program products determine whether to implement load sharing based on utilization information indicative of a load and build the network responsive resource with a client-side scripted component as the substitute scripted component.

Abstract: A mixing vial having a hollow interior chamber with a tubular portion having distal and proximal open ends and a stopper positioned in sealing relationship in the tubular portion, the stopper having a hollow interior chamber with an open end and a dislodgeable plug positioned in and sealing the open end.

Abstract: A mooring device with a rod having a first rod end and a second rod end. There is a suction cup assembly having a first suction cup mount with a first mount end and a second mount end. The first mount end is coupled with the first rod end. The assembly also has a first suction cup coupled with the second mount end. The mooring device includes a coupler engaged with the rod. The coupler is configured for at least one of lateral movement with respect to the rod, rotational movement with respect to the rod, and combinations thereof.

Abstract: A system and method for monitoring and controlling build quality during electron beam manufacturing of a build part. The system may include at least one electron beam source to direct at least one electron beam onto a plurality of deposited layers of metallic powder to form a melt pool, a detector to detect in real-time backscattered energy ejected from the melt pool and indicative of a defect in the build part and generate a detection signal representative of the defect. A controller receives and analyzes the detection signal and generates a corrective signal for control of at least one of the actuator and the at least one electron beam source to direct the at least one electron beam onto the plurality of deposited layers of metallic powder to sequentially consolidate patterned portions of the plurality of deposited metallic powder layers to adaptively form the three-dimensional build part.

Abstract: A design is presented for a structured cable suitable for carrying a large electric current in a cable-in-conduit comprising an assembly of rectangular stacks of thin superconducting tapes, with provisions for mechanical support of large mechanical stress and cross-flow of cooling fluid capable of removing large amounts of heat.

Abstract: A mooring device with a rod having a first rod end and a second rod end. There is a suction cup assembly having a first suction cup mount with a first mount end and a second mount end. The first mount end is coupled with the first rod end. The assembly also has a first suction cup coupled with the second mount end. The mooring device includes a coupler engaged with the rod. The coupler is configured for at least one of lateral movement with respect to the rod, rotational movement with respect to the rod, and combinations thereof.

Abstract: Aspects of the disclosure relate to information security by identifying unique or related factors in common between individuals subject to a common threat vector. Data mining and data acquisition of public and non-public user information is performed to prevent, disrupt, and/or address criminal, cyber, and fraudulent threats. The information can be normalized into template(s) to align information across disparate datasets and enable efficient storage of the big data into appropriate fields to be tracked. The information can be stored in data warehouse(s) or in multidimensional data structure(s) for investigation if a threat vector against a group of individuals is detected. The multidimensional data can be analyzed to identify direct connections, common connecting entities, and/or connectivity clusters between individuals who were attacked or who may be attacked in the future.

Abstract: A dispensing closure system includes an upper closure portion and a lower closure portion including an axial flow conduit and a vent conduit. The upper closure portion is axially movable relative to lower closure portion between shipping and dispensing positions. A seal is disposed on the lower closure portion over the flow and vent conduits. A peripheral spacing strip is removably secured to the upper closure portion and engages with either the lower closure or the outside of the container to prevent movement. A piercing probe includes piercing elements in alignment with the flow and vent conduits for piercing the seal. In the shipping position, the piercing elements are spaced from the seal. However, when the spacing strip is removed and the upper closure portion is axially moved to the dispensing position, the piercing elements pierce the seal to open the flow conduit and the vent conduit.

Abstract: The present disclosure relates to amino acid sequences that are directed against (as defined herein) any of IL-17A, IL-17F and/or IL-17A/F including combinations thereof, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed for valve body apparatus for use with fluid valves. An example fluid valve apparatus includes a valve body including a housing positioned on an exterior surface of the valve body, a calibration set screw disposed in the housing via a recessed aperture, and a cover coupled to the housing to seal the calibration set screw from external access.

Abstract: A method for coordinating data between a plurality of sample processing systems is disclosed. In some implementations, the method comprises providing, using a central control unit, data to a pre-analytical sample processing system identifying a sample undergoing pre-analytical processing, receiving data, at the central control unit, indicating the transfer of the sample to an analytical system, providing, from the central control unit (CCU), data associated with the sample to the analytical system, and receiving a result associated with the sample from the analytical system.

Abstract: An apparatus for connecting items, even with irregular surfaces, to each other while maintaining a minimum distance between the items. The apparatus can have a suction cup comprising a cup body, a sealing edge, an internal surface, an external surface, a fluid pathway extending from an interior of the cup body to the exterior of the cup body, and a plurality of cleats positioned on the internal surface of the cup body extending radially inward from proximate the sealing edge. The thickness of each cleat increases distal to the sealing edge. When air is pumped out of the cup body to allow it to seal to a surface, the cleats create a desirable fluid flow profile allowing for a tighter and more efficacious seal.