Patents by Inventor John Secrist

John Secrist has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of thioarabinofuranosyl compounds and use thereof
    Publication number: 20060287320
    Abstract: Patients suffering from cancer are treated by being administered a compound represented by the following formula: wherein each R individually is H or an aliphatic or aromatic acyl group; A is selected from the group consisting of wherein X is selected from the group consisting of hydrogen, fluorine, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, cyano and nitro. The above compounds also inhibit DNA replication in mammalian cells.
    Type: Application
    Filed: August 24, 2006
    Publication date: December 21, 2006
    Applicant: Southern Research Institute
    Inventors: John Secrist, Kamal Tiwari, John Montgomery, William Hinds
  • Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-B-D-arabinofuranosyl)-9H-purin-6-amine
    Publication number: 20050288500
    Abstract: 2-Chloro-9-(2-deoxy-2-fluoro-?-D-arabinofuranosyl)-9H-purin-6-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofiranose; and reacting with a base such as ammonia to provide 2-chloro-9-(2-deoxy-2-fluoro-?-D-arabinofuranosyl)-9H-purin-6-amine. When the purine reactant is substituted in the 6 position with a halogen, a reaction step with an alkoxide is carried out prior to the reaction with ammonia.
    Type: Application
    Filed: August 16, 2005
    Publication date: December 29, 2005
    Applicant: Southern Research Institute
    Inventors: John Montgomery, Anita Fowler, John Secrist
  • 4'-Thio-L-xyloy furanosyl nucleosides, precursors thereof, preparation and use thereof
    Publication number: 20050130969
    Abstract: Compounds represented by the formula 1: A is selected from the group consisting of wherein each R individually is H or acyl, Y is X, N3, NH2, monoalkylamino, or dialkylamino; Z is O or S; and X is selected from the group consisting of hydrogen, halo, hydroxy, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, thioaryl, thioalkyl, allylamino, cyano and nitro; tautomers thereof; and pharmaceutically acceptable salts thereof are provided along with methods for their fabrication. Various of these compounds can be used as anticancer agents, or antiviral agents or to inhibit DNA replication.
    Type: Application
    Filed: January 31, 2005
    Publication date: June 16, 2005
    Applicant: Southern Research Institute
    Inventors: John Secrist, Kamal Tiwari, John Montgomery
  • Thioarabinofuranosyl compounds and use thereof
    Publication number: 20050038025
    Abstract: Patients suffering from cancer are treated by being administered a compound represented by the following formula: wherein each R individually is H or an aliphatic or aromatic acyl group; A is selected from the group consisting of wherein X is selected from the group consisting of hydrogen, fluorine, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, cyano and nitro. The above compounds also inhibit DNA replication in mammalian cells.
    Type: Application
    Filed: September 13, 2004
    Publication date: February 17, 2005
    Applicant: SOUTHERN RESEARCH INSTITUTE
    Inventors: John Secrist, Kamal Tiwari, John Montgomery