Patents by Inventor John Sellstedt

John Sellstedt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of chirally pure amino alcohol intermediates, derivatives thereof, and uses thereof
    Patent number: 7737303
    Abstract: A method of selectively preparing a chiral 2S-amino alcohol useful in preparation of an amide sulfonated or acylated with alkyl, substituted aryl or substituted heteroaryl is described. The method involves reacting a di-tert-butyl diazene-1,2-dicarboxylate with a (4S)-4-benzyl-3-[(S)-trifluoromethyl-alkyl substituted alkanoyl]-1,3-oxazolidin-2-one to afford a di-tert-butyl 1-(1S,2S)-([(4S)-4-benzyl-2-oxo-1,3-oxazolidine-3-yl]-carbonyl}-trifluoromethyl-alkyl substituted alkyl)hydrazine-1,2-dicarboxylate. This dicarboxylate is then reduced to yield di-tert-butyl 1-(1S,2S)-[trifluoromethyl-alkyl substituted alkyl]hydrazine-1-(hydroxymethyl)-1,2-dicarboxylate. The resulting product is deblocked with an acid to yield the acid addition salt of (2S,3S)-trifluoro-hydrazino-methyl alkan-1-ol. The acid addition salt of (2S,3S)-trifluoro-2-hydrazino-methyl alkan-1-ol is hydrogenated in the presence of a suitable metal catalyst to yield the amino alcohol (2S,3S)-2-amino-trifluoro-methyl alkan-1-ol HCl.
    Type: Grant
    Filed: August 24, 2009
    Date of Patent: June 15, 2010
    Assignee: Wyeth LLC
    Inventors: John Sellstedt, Gloria Cheal, Razzak Noureldin, Anita Wai-Yin Chan, Panolil Raveendranath, Thomas Joseph Caggiano
  • PRODUCTION OF CHIRALLY PURE AMINO ALCOHOL INTERMEDIATES, DERIVATIVES THEREOF, AND USES THEREOF
    Publication number: 20100016639
    Abstract: A method of selectively preparing a chiral 2S-amino alcohol useful in preparation of an amide sulfonated or acylated with alkyl, substituted aryl or substituted heteroaryl is described. The method involves reacting a di-tert-butyl diazene-1,2-dicarboxylate with a (4S)-4-benzyl-3-[(S)-trifluoromethyl-alkyl substituted alkanoyl]-1,3-oxazolidin-2-one to afford a di-tert-butyl 1-(1S,2S)-([(4S)-4-benzyl-2-oxo-1,3-oxazolidine-3-yl]-carbonyl}-trifluoromethyl-alkyl substituted alkyl)hydrazine-1,2-dicarboxylate. This dicarboxylate is then reduced to yield di-tert-butyl 1-(1S,2S)-[trifluoromethyl-alkyl substituted alkyl]hydrazine-1-(hydroxymethyl)-1,2-dicarboxylate. The resulting product is deblocked with an acid to yield the acid addition salt of (2S,3S)-trifluoro-hydrazino-methyl alkan-1-ol. The acid addition salt of (2S,3S)-trifluoro-2-hydrazino-methyl alkan-1-ol is hydrogenated in the presence of a suitable metal catalyst to yield the amino alcohol (2S,3S)-2-amino-trifluoro-methyl alkan-1-ol HCl.
    Type: Application
    Filed: August 24, 2009
    Publication date: January 21, 2010
    Applicant: Wyeth
    Inventors: John Sellstedt, Gloria Cheal, Razzak Noureldin, Anita Wai-Yin Chan, Panolil Raveendranath, Thomas Joseph Caggiano
  • Production of chirally pure amino alcohol intermediates, derivatives thereof, and uses thereof
    Patent number: 7598422
    Abstract: A method of selectively preparing a chiral 2S-amino alcohol useful in preparation of an amide sulfonated or acylated with alkyl, substituted aryl or substituted heteroaryl is described. The method involves reacting a di-tert-butyl diazene-1,2-dicarboxylate with a (4S)-4-benzyl-3-[(S)-trifluoromethyl-alkyl substituted alkanoyl]-1,3-oxazolidin-2-one to afford a di-tert-butyl 1-(1S,2S)-([(4S)-4-benzyl-2-oxo-1,3-oxazolidine-3-yl]-carbonyl}-trifluoromethyl-alkyl substituted alkyl)hydrazine-1,2-dicarboxylate. This dicarboxylate is then reduced to yield di-tert-butyl 1-(1S,2S)-[trifluoromethyl-alkyl substituted alkyl]hydrazine-1-(hydroxymethyl)-1,2-dicarboxylate. The resulting product is deblocked with an acid to yield the acid addition salt of (2S,3S)-trifluoro-hydrazino-methyl alkan-1-ol. The acid addition salt of (2S,3S)-trifluor-2-hydrazino-methyl alkan-1-ol is hydrogenated in the presence of a suitable metal catalyst to yield the amino alcohol (2S,3S)-2-amino-trifluoro-methyl alkan-1-ol HCl.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: October 6, 2009
    Assignee: Wyeth
    Inventors: John Sellstedt, Gloria Cheal, Razzak Noureldin, Anita Wai-Yin Chan, Panolil Raveendranath, Thomas Joseph Caggiano
  • Production of chirally pure amino alcohol intermediates, derivatives thereof, and uses thereof
    Publication number: 20070249869
    Abstract: A method of selectively preparing a chiral 2S-amino alcohol useful in preparation of an amide sulfonated or acylated with alkyl, substituted aryl or substituted heteroaryl is described. The method involves reacting a di-tert-butyl diazene-1,2-dicarboxylate with a (4S)-4-benzyl-3-[(S)-trifluoromethyl-alkyl substituted alkanoyl]-1,3-oxazolidin-2-one to afford a di-tert-butyl 1-(1S,2S)-([(4S)-4-benzyl-2-oxo-1,3-oxazolidine-3-yl]-carbonyl}-trifluoromethyl-alkyl substituted alkyl)hydrazine-1,2-dicarboxylate. This dicarboxylate is then reduced to yield di-tert-butyl 1-(1S,2S)-[trifluoromethyl-alkyl substituted alkyl]hydrazine-1-(hydroxymethyl)-1,2-dicarboxylate. The resulting product is deblocked with an acid to yield the acid addition salt of (2S,3S)-trifluoro-hydrazino-methyl alkan-1-ol. The acid addition salt of (2S,3S)-trifluor-2-hydrazino-methyl alkan-1-ol is hydrogenated in the presence of a suitable metal catalyst to yield the amino alcohol (2S,3S)-2-amino-trifluoro-methyl alkan-1-ol HCl.
    Type: Application
    Filed: April 18, 2007
    Publication date: October 25, 2007
    Applicant: Wyeth
    Inventors: John Sellstedt, Gloria Cheal, Razzak Noureldin, Anita Wai-Yin Chan, Panolil Raveendranath, Thomas Joseph Caggiano
  • Process for the Synthesis of Derivatives of 2,3-Dihydro-1,4-Dioxino-[2,3-f] Quinolines
    Publication number: 20070123705
    Abstract: Methods of preparing compounds of Formula I are provided.
    Type: Application
    Filed: December 4, 2006
    Publication date: May 31, 2007
    Applicant: Wyeth
    Inventors: Anita Chan, Timothy Curran, Silvio Iera, Warren Chew, John Sellstedt, Galina Vid, Gregg Feigelson, Zhixian Ding
  • Quinoxaline dihydrohalide dihydrates and synthetic methods therefor
    Publication number: 20060211699
    Abstract: Crystalline polymorph forms of Gonadotropin Releasing Hormone receptor antagonists, including crystalline polymorphs of quinoxaline dihydrohalide dihydrates, in particular crystalline polymorphs of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]-piperazin-1-yl}methyl)-quinoxaline dihydrochloride dihydrate, methods of making the same, as well as pharmaceutical compositions, and dosage forms containing them are disclosed.
    Type: Application
    Filed: March 7, 2006
    Publication date: September 21, 2006
    Applicant: Wyeth
    Inventors: Silvio Iera, Abdolsamad Tadayon, John Sellstedt, Subodh Deshmukh
  • Process for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino-[2,3-f] quinoline
    Publication number: 20060074240
    Abstract: Methods of preparing compounds of Formula I are provided.
    Type: Application
    Filed: November 18, 2005
    Publication date: April 6, 2006
    Applicant: Wyeth
    Inventors: Anita Chan, Timothy Curran, Silvio Iera, Warren Chew, John Sellstedt, Galina Vid, Gregg Feigelson, Zhixian Ding
  • Regioselective synthesis of rapamycin derivatives
    Publication number: 20010039338
    Abstract: This invention provides a regioselective process for preparing a 42-ester or ether of rapamycin, and 31-silyl ether intermediates.
    Type: Application
    Filed: June 7, 2001
    Publication date: November 8, 2001
    Applicant: American Home Products Corporation
    Inventors: Chia-Cheng Shaw, John Sellstedt, Razzak Noureldin, Gloria K. Cheal, Genevieve Fortier
  • Regioselective synthesis of rapamycin derivatives
    Patent number: 6277983
    Abstract: This invention provides a regioselective process for preparing a 42-ester or ether of rapamycin, and 31-silyl ether intermediates.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: August 21, 2001
    Assignee: American Home Products Corporation
    Inventors: Chia-Cheng Shaw, John Sellstedt, Razzak Noureldin, Gloria K. Cheal, Genevieve Fortier