Abstract: Apparatus (1) for permitting release of a motor vehicle foot pedal, in a frontal crash, having a primary pedal arm (12) carrying a foot pad (14) and a secondary pedal arm (2) linked to the primary pedal arm (12) and provided at its lower end an open aperture (5) to receive a portion of a linkage pin (17). A trigger lever (6) is mounted on the secondary pedal arm (15) to be struck in a crash situation, and displaced, by a non-deformable portion (20) of a motor vehicle. The trigger lever (6) is provided at its other end with an open aperture (10) also to receive the linkage pin (17) and, in normal operation of the arrangement, to captivate the linkage pin (17) within the open aperture (5). A shearable rivet (7) connects the trigger lever (6) and the secondary pedal arm (2), restraining displacement of the trigger lever (6) with respect to the secondary pedal arm (2) so as to retain captivation of the linkage pin (17) until a crash occurs.

Abstract: The invention provides isolated nucleic acids encoding a variety of proteins and nucleic acids having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

Abstract: The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

Abstract: The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: An arrangement (1) for permitting release of a motor vehicle foot pedal, in a frontal crash of sufficient magnitude, comprising a primary pedal arm (12) carrying a foot pad (14) and a secondary pedal arm (2) linked to the primary pedal arm (12) and provided at its lower end an open aperture (5) to receive a portion of a linkage pin (17). A trigger lever (6) mounted on the secondary pedal arm (15) (struck in a crash situation), and displaced, by a portion (20) of a motor vehicle designed not to deform. The trigger lever (6) is provided at its other end with an open aperture (10) also to receive the linkage pin (17) and, in normal operation of the arrangement, to captivate the linkage pin (17) within the open aperture (5). A shearable rivet (7) connects the trigger lever (6) and the secondary pedal arm (2), restraining displacement of the trigger lever (6) with respect to the secondary pedal arm (2) so as to retain captivation of the linkage pin (17) until a crash occurs.

Abstract: The healing of chronic wounds, such as leg ulcers, is accelerated via topical administration of a serine protease inhibitor, such as PAI-2. Wound healing also is promoted using combinations of protease inhibitors, such as PAI-2 with other serine protease inhibitors and/or with protease inhibitors such inhibitors of metalloproteinases, acid proteases, and thiol proteases, respectively.

Abstract: Psoriasis may be treated by topical administration of a urokinase inhibitor, such as PAI-2, or a combination of protease inhibitors, such as PAI-2 with other serine protease inhibitors and/or with protease inhibitors such as inhibitors of metalloproteinases, acid proteases, and thiol proteases.

Abstract: A shaft (14) is formed with a magnetically transparent portion within its length, so as to enable passage therethrough of electromagnetic flux from stator poles, to a further shaft (20) to cause shaft (20) to move to a position in space, coaxial with the shaft (20).

Abstract: Disclosed is a substantially purified antigen derived from a first species of parasitic nematodes, which antigen is capable of providing protection to a host from parasitism infestation by a second nematode species, which may be the same as or different from the first nematode species, following vaccination of the host with the antigen, characterized in that the antigen is proteinaceous, has a pI between 3.8 and 4.4, can be bound by lentil lectin and Helix promatia and has a molecular weight of approximately 45 kD as determined by SDS-PAGE.

Abstract: Disclosed is a substantially purified antigen derived from a first parasitic nematode species which, when administered to a host animal, is capable of protecting the host animal from infestation by a second parasitic nematode species, wherein the first and second parasitic nematode species may be the same or different, and the antigen has an apparent molecular weight of 40 kD as determined by SDS-PAGE under reducing conditions.

Abstract: An aircraft mounted gas turbine engine system comprises a three shaft propulsive gas turbine engine having three electrical generators; each one respectively associated with one shaft of the engine. Two of the electrical generators are additionally configured so as to function as electric motors so as to facilitate power transfer between the engine shafts. One of the electric generators provides the primary source of electrical power for the aircraft, while the remaining electrical generators provide electrical power for the engine and back-up power for the aircraft.

Abstract: Disclosed is a substantially purified antigen derived from a first parasitic nematode species which, when administered to a host animal, is capable of protecting the host animal from infestation by a second parasitic mematode species, wherein the first and second parasitic nematode species may be the same or different, and the antigen has an apparent molecular weight of 40 kD as determined by SDS-PAGE under reducing conditions.

Abstract: A flow control device ?1! for insertion into a conduit to control the flow rate of fluid flow therethrough. The device ?1! includes two opposed dished baffle plates ?2! and ?3! defining a chamber ?4! therebetween. Each baffle plate has a generally centrally located orifice ?6! and ?7! respectively. The device ?1! is adapted for positioning substantially transverse to the longitudinal extent of the conduit by means of, for example, flanges ?10 and 11! or a pre-connected threaded sleeve ?15!, such that fluid flow along the conduit is diverted through the orifices ?6! and ?7!. Additional spaced baffle plates ?5! may be added on the downstream side to fine tune the flow rate.

Abstract: Services, such as electricity and water, are supplied through conduits to moving machinery such as a longwall mining machine which moves along a conveyor or other fixed path. A channel having an open mouth which is flexibly sealed is disposed alongside the path and contains supply conduits for the machine. A sleeve projects through the channel seals into the body of the channel and guides the conduits to the machine. A gas may be fed to the machine via the channel and sleeve. As the machine moves the conduits bend over themselves.

Abstract: A plate type solar absorber is provided with two sets of ducts each with its own header system. The ducts of each set are proportioned to provide for greater and lesser flow rates of liquid to be heated and may be selectively operated to provide heated liquid at differing temperatures. Means are provided to enable air for room heating to be drawn into a building through the set of larger ducts.

Abstract: A method of manufacturing a disc wheel which is of generally Y-shape in cross sections radial of the rotary axis of the wheel, the stem of the Y providing the central disc of the wheel and having holes for the normal wheel bolts or studs, and the bifurcations of the Y providing the wheel rim. The wheel has an annular metal reinforcement having parts located in the stem and in one of the bifurcations of the Y, the reinforcement including holes corresponding to the holes in the finished wheel for the bolts or studs. A covering of plastics material is moulded over the reinforcement, the covering having an integral extension which provides the other bifurcation of the Y. The plastics covering is moulded onto the reinforcement in a mould cavity defined between first and second mould portions which are movable towards and away from one another in directions parallel to the rotary axis of the wheel between open and closed positions.

Abstract: A method of injection moulding a pallet comprising a reinforcement or reinforcing frame provided with an encapsulation of thermoplastic polymeric material, wherein the reinforcement is held in an open mould cavity by vertical projections before the mould cavity is closed and after closure of the cavity is supported in the cavity by horizontal projections whereupon said material is injected into the cavity to encapsulate the reinforcement, the projections subsequently being withdrawn the cavity opened and the pallet removed. The reinforcement or reinforcing frame of the pallet is in the form of two interconnected assemblies of crossed rods.