Patents by Inventor John Shultz

John Shultz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxidized glutathione assay
    Patent number: 10889849
    Abstract: The present invention provides an assay for detection of oxidized glutathione (GSSG).
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: January 12, 2021
    Assignee: PROMEGA CORPORATION
    Inventors: Fen Huang, Dieter Klaubert, John Shultz, Wenhui Zhou
  • Compounds and methods for assaying redox state of metabolically active cells and methods for measuring NAD(P)/NAD(P)H
    Patent number: 9951372
    Abstract: The present invention provides compounds and methods for assaying redox state of metabolically active cells and methods for assaying enzyme activity and/or metabolite level by coupling to redox defining co-factor NAD(P)/NAD(P)H measurement.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: April 24, 2018
    Assignee: PROMEGA CORPORATION
    Inventors: Wenhui Zhou, Jolanta Vidugiriene, Helene A. Benink, James J. Cali, Sarah Duellman, Dieter Klaubert, Donna Leippe, Martha O'Brien, John Shultz, Mary Sobol
  • Protein labeling with cyanobenzothiazole conjugates
    Patent number: 9932365
    Abstract: The invention provides compounds and methods for site-specifically labeling proteins with cyanobenzothiazole derivatives of formula I. For example, the invention provides methods for labeling the N-terminus of a protein that terminates with a cysteine residue. The invention also provides methods for isolating an N-terminally labeled protein and methods for detecting an N-terminally labeled protein.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: April 3, 2018
    Assignee: PROMEGA CORPORATION
    Inventors: Jessica Kelts, Poncho Meisenheimer, John Shultz
  • OXIDIZED GLUTATHIONE ASSAY
    Publication number: 20180030503
    Abstract: The present invention provides an assay for detection of oxidized glutathione (GSSG).
    Type: Application
    Filed: October 5, 2017
    Publication date: February 1, 2018
    Inventors: Fen Huang, Dieter Klaubert, John Shultz, Wenhui Zhou
  • Oxidized glutathione assay
    Patent number: 9816127
    Abstract: The present invention provides an assay for detection of oxidized glutathione (GSSG).
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: November 14, 2017
    Assignee: PROMEGA CORPORATION
    Inventors: Fen Huang, Dieter Klaubert, John Shultz, Wenhui Zhou
  • PROTEIN LABELING WITH CYANOBENZOTHIAZOLE CONJUGATES
    Publication number: 20170283456
    Abstract: The invention provides compounds and methods for site-specifically labeling proteins with cyanobenzothiazole derivatives of formula I. For example, the invention provides methods for labeling the N-terminus of a protein that terminates with a cysteine residue. The invention also provides methods for isolating an N-terminally labeled protein and methods for detecting an N-terminally labeled protein.
    Type: Application
    Filed: June 15, 2017
    Publication date: October 5, 2017
    Inventors: Jessica Kelts, Poncho Meisenheimer, John Shultz
  • Protein labeling with cyanobenzothiazole conjugates
    Patent number: 9689868
    Abstract: The invention provides compounds and methods for site-specifically labeling proteins with cyanobenzothiazole derivatives of formula I. For example, the invention provides methods for labeling the N-terminus of a protein that terminates with a cysteine residue. The invention also provides methods for isolating an N-terminally labeled protein and methods for detecting an N-terminally labeled protein.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: June 27, 2017
    Assignee: PROMEGA CORPORATION
    Inventors: Jessica Kelts, Poncho Meisenheimer, John Shultz
  • Method and apparatus for forming associations and communicating between devices
    Patent number: 9654179
    Abstract: The present invention relates to the field of proximity communications and especially methods for establishing associations, transferring power and communicating data between devices. Devices are proposed to interact with each other, initially by being brought into close proximity to initiate transfer of data that enables the device to communicate with other devices similarly brought together. The devices can be used as a controller or an appliance or both. There is also provided a power transfer mechanism for controller and appliance devices which do not have locally available power at the time the initial proximity action is taking place, so that the processes associated with the data transfer can take place regardless. There is also described a two part device, one part of which provides the proximity communications capability the other part does not have.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: May 16, 2017
    Assignee: XPED HOLDINGS PTY LTD
    Inventors: John Shultz, Christopher Richard Wood
  • PROTEIN LABELING WITH CYANOBENZOTHIAZOLE CONJUGATES
    Publication number: 20170016888
    Abstract: The invention provides compounds and methods for site-specifically labeling proteins with cyanobenzothiazole derivatives of formula I. For example, the invention provides methods for labeling the N-terminus of a protein that terminates with a cysteine residue. The invention also provides methods for isolating an N-terminally labeled protein and methods for detecting an N-terminally labeled protein.
    Type: Application
    Filed: September 30, 2016
    Publication date: January 19, 2017
    Inventors: Jessica Kelts, Poncho Meisenheimer, John Shultz
  • Protein labeling with cyanobenzothiazole conjugates
    Patent number: 9459249
    Abstract: The invention provides compounds and methods for site-specifically labeling proteins with cyanobenzothiazole derivatives of formula I. For example, the invention provides methods for labeling the N-terminus of a protein that terminates with a cysteine residue. The invention also provides methods for isolating an N-terminally labeled protein and methods for detecting an N-terminally labeled protein.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: October 4, 2016
    Assignee: PROMEGA CORPORATION
    Inventors: Jessica Anderson, Poncho Meisenheimer, John Shultz
  • Compounds and methods for assaying redox state of metabolically active cells and methods for measuring NAD(P)/NAD(P)H
    Patent number: 9273343
    Abstract: The present invention provides compounds and methods for assaying redox state of metabolically active cells and methods for assaying enzyme activity and/or metabolite level by coupling to redox defining co-factor NAD(P)/NAD(P)H measurement.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: March 1, 2016
    Assignee: PROMEGA CORPORATION
    Inventors: James J. Cali, Sarah Duellman, Dieter Klaubert, Donna Leippe, Martha O'Brien, John Shultz, Jolanta Vidugiriene, Wenhui Zhou, Mary Sobol
  • METHOD AND APPARATUS FOR FORMING ASSOCIATIONS AND COMMUNICATING BETWEEN DEVICES
    Publication number: 20150044966
    Abstract: The present invention relates to the field of proximity communications and especially methods for establishing associations, transferring power and communicating data between devices. Devices are proposed to interact with each other, initially by being brought into close proximity to initiate transfer of data that enables the device to communicate with other devices similarly brought together. The devices can be used as a controller or an appliance or both. There is also provided a power transfer mechanism for controller and appliance devices which do not have locally available power at the time the initial proximity action is taking place, so that the processes associated with the data transfer can take place regardless. There is also described a two part device, one part of which provides the proximity communications capability the other part does not have.
    Type: Application
    Filed: March 28, 2013
    Publication date: February 12, 2015
    Inventors: John Shultz, Christopher Richard Wood
  • Detection of hydrogen peroxide
    Patent number: 8937183
    Abstract: The present invention provides compounds useful for detection of hydrogen peroxide and methods of using same.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: January 20, 2015
    Assignee: Promega Corporation
    Inventors: Dieter Klaubert, John Shultz, James Unch, Michael P. Valley, Hui Wang, Wenhui Zhou
  • DETECTION OF HYDROGEN PEROXIDE
    Publication number: 20140329257
    Abstract: The present invention provides compounds useful for detection of hydrogen peroxide and methods of using same.
    Type: Application
    Filed: July 21, 2014
    Publication date: November 6, 2014
    Inventors: Dieter Klaubert, John Shultz, James Unch, Michael P. Valley, Hui Wang, Wenhui Zhou
  • Detection of hydrogen peroxide
    Patent number: 8785652
    Abstract: The present invention provides compounds useful for detection of hydrogen peroxide and methods of using same.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: July 22, 2014
    Assignee: Promega Corporation
    Inventors: Dieter Klaubert, John Shultz, James Unch, Michael P. Valley, Hui Wang, Wenhui Zhou
  • COMPOUNDS AND METHODS FOR ASSAYING REDOX STATE OF METABOLICALLY ACTIVE CELLS AND METHODS FOR MEASURING NAD(P)/NAD(P)H
    Publication number: 20140093894
    Abstract: The present invention provides compounds and methods for assaying redox state of metabolically active cells and methods for assaying enzyme activity and/or metabolite level by coupling to redox defining co-factor NAD(P)/NAD(P)H measurement.
    Type: Application
    Filed: September 20, 2013
    Publication date: April 3, 2014
    Applicant: PROMEGA CORPORATION
    Inventors: Helene A. BENINK, James J. CALI, Sarah DUELLMAN, Dieter KLAUBERT, Donna LEIPPE, Martha O'BRIEN, John SHULTZ, Jolanta VIDUGIRIENE, Wenhui ZHOU, Mary SOBOL
  • Bioluminescent assays using cyanobenzothiazole compounds
    Patent number: 8592172
    Abstract: The invention provides methods that employ derivatives of 2-cyano-6-hydroxy- or 2-cyano-6-amino-benzothiazole, for example, in a bioluminogenic reaction. The invention further provides methods for detecting or determining the presence of molecules and/or enzymes, the modulator activity of such molecules, and/or the activity of such enzymes. The methods are adaptable to high-throughput format.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: November 26, 2013
    Assignee: Promega Corporation
    Inventors: Jessica Kelts, Poncho Meisenheimer, John Shultz, James J. Cali, Dongping Ma
  • Bioluminescent detection of cyanohydroxy benzothiazole compounds
    Patent number: 8551721
    Abstract: The invention provides methods that employ derivatives of 2-cyano-6-hydroxy- or 2-cyano-6-amino-benzothiazole, for example, in a bioluminogenic reaction. Also provided are novel compounds that can be used in the methods. The invention further provides methods for detecting or determining the presence of molecules and/or enzymes, the modulator activity of such molecules, and/or the activity of such enzymes. The methods are adaptable to high-throughput format.
    Type: Grant
    Filed: September 9, 2009
    Date of Patent: October 8, 2013
    Assignee: Promega Corporation
    Inventors: Jessica Anderson, Poncho Meisenheimer, John Shultz, James J. Cali, Dongping Ma
  • Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
    Patent number: 8476450
    Abstract: A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided. Compounds and compositions for carrying out the methods of the invention are also provided.
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: July 2, 2013
    Assignee: Promega Corporation
    Inventors: James J. Cali, William Daily, Erika Hawkins, Dieter Klaubert, Jianquan Liu, Poncho Meisenheimer, Michael Scurria, John Shultz, James Unch, Michael P. Valley, Keith V. Wood, Wenhui Zhou
  • COMPOUNDS AND METHODS FOR ASSAYING REDOX STATE OF METABOLICALLY ACTIVE CELLS AND METHODS FOR MEASURING NAD(P)/NAD(P)H
    Publication number: 20130130289
    Abstract: The present invention provides compounds and methods for assaying redox state of metabolically active cells and methods for assaying enzyme activity and/or metabolite level by coupling to redox defining co-factor NAD(P)/NAD(P)H measurement.
    Type: Application
    Filed: August 31, 2012
    Publication date: May 23, 2013
    Applicant: PROMEGA CORPORATION
    Inventors: Helene A. BENINK, James J. CALI, Sarah DUELLMAN, Dieter KLAUBERT, Donna LEIPPE, Martha O'BRIEN, John SHULTZ, Jolanta VIDUGIRIENE, Wenhui ZHOU, Mary SOBOL