Patents by Inventor John Shumaker

John Shumaker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Parallel primer extension approach to nucleic acid sequence analysis
    Patent number: 7001722
    Abstract: A method of analyzing a polynucleotide of interest, comprising providing one or more sets of consecutive oligonucleotide primers differing within each set by one base at the growing end therof; annealing a single strand of the polynucleotide or a fragment of the polynucleotide to the oligonucleotide primers under hybridization conditions; subjecting the primers to single base extension reactions with a polymerase and terminating nucleotides, the terminating nucleotides being mutually distinguishable; and observing the location and identity of each terminating nucleotide to thereby analyze the sequence or a part of the nucleotide sequence of the polynucleotide of interest, is disclosed. An apparatus comprising a solid support to which is attached at defined locations thereon one or more sets of consecutive oligonucleotide primers differing within each set by one base at the growing end thereof is also described.
    Type: Grant
    Filed: November 13, 2000
    Date of Patent: February 21, 2006
    Assignees: Baylor College of Medicine, Pharmacia Biotech AB
    Inventors: C. Thomas Caskey, John Shumaker, Andres Metspalu
  • Parallel primer extension approach to nucleic acid sequence analysis
    Publication number: 20030082613
    Abstract: A method of analyzing a polynucleotide of interest, comprising providing one or more sets of consecutive oligonucleotide primers differing within each set by one base at the growing end therof, annealing a single strand of the polynucleotide or a fragment of the polynucleotide to the oligonucleotide primers under hybridization conditions; subjecting the primers to single base extension reactions with a polymerase and terminating nucleotides, the terminating nucleotides being mutually distinguishable; and observing the location and identity of each terminating nucleotide to thereby analyze the sequence or a part of the nucleotide sequence of the polynucleotide of interest, is disclosed. An apparatus comprising a solid support to which is attached at defined locations thereon one or more sets of consecutive oligonucleotide primers differing within each set by one base at the growing end thereof is also described.
    Type: Application
    Filed: September 25, 2002
    Publication date: May 1, 2003
    Applicant: Baylor College of Medicine
    Inventors: C. Thomas Caskey, John Shumaker, Andres Metspalu
  • Parallel primer extension approach to nucleic acid sequence analysis
    Patent number: 6153379
    Abstract: A method of analyzing a polynucleotide of interest, comprising providing one or more sets of consecutive oligonucleotide primers differing within each set by one base at the growing end therof; annealing a single strand of the polynucleotide or a fragment of the polynucleotide to the oligonucleotide primers under hybridization conditions; subjecting the primers to single base extension reactions with a polymerase and terminating nucleotides, the terminating nucleotides being mutually distinguishable; and observing the location and identity of each terminating nucleotide to thereby analyze the sequence or a part of the nucleotide sequence of the polynucleotide of interest, is disclosed. An apparatus comprising a solid support to which is attached at defined locations thereon one or more sets of consecutive oligonucleotide primers differing within each set by one base at the growing end thereof is also described.
    Type: Grant
    Filed: March 6, 1996
    Date of Patent: November 28, 2000
    Assignees: Baylor College of Medicine, Pharmacia Biotech AB
    Inventors: C. Thomas Caskey, John Shumaker, Andres Metspalu
  • Multi-site detection apparatus
    Patent number: 5891630
    Abstract: A method and apparatus for identifying molecular structures within a sample substance using an array having a plurality of test sites upon which the sample substance is applied. Each test site includes a probe formed therein to bond with an associated target molecular structure. An electrical signal is applied to the test site and the electrical properties of the test sites are detected to determine which probes have bonded to an associated target molecular structure.
    Type: Grant
    Filed: April 15, 1996
    Date of Patent: April 6, 1999
    Inventors: Mitchell D. Eggers, Michael E. Hogan, Kenneth Loren Beattie, John Shumaker, Daniel J. Ehrlich, Mark Hollis
  • Multi site molecule detection method
    Patent number: 5670322
    Abstract: A method and apparatus for identifying molecular structures within a sample substance using an array having a plurality of test sites upon which the sample substance is applied. Each test site includes a probe formed therein to bond with an associated target molecular structure. An electrical signal is applied to the test site and the electrical properties of the test sites are detected to determine which probes have bonded to an associated target molecular structure.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: September 23, 1997
    Inventors: Mitchell D. Eggers, Michael E. Hogan, Kenneth Loren Beattie, John Shumaker, Daniel J. Ehrlich, Mark Hollis
  • Multi-site detection apparatus
    Patent number: 5532128
    Abstract: A method and apparatus for identifying molecular structures within a sample substance using an array having a plurality of test sites upon which the sample substance is applied. Each test site includes a probe formed therein to bond with an associated target molecular structure. An electrical signal is applied to the test site and the electrical properties of the test sites are detected to determine which probes have bonded to an associated target molecular structure.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: July 2, 1996
    Assignee: Houston Advanced Research Center
    Inventors: Mitchell D. Eggers, Michael E. Hogan, Kenneth L. Beattie, John Shumaker, Daniel J. Ehrlich, Mark Hollis