Patents by Inventor John Silke

John Silke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for Modulating T Cell Activation
    Publication number: 20220193196
    Abstract: The present invention relates to methods, compositions, and kits for increasing the activation of effector T cells in a subject or inhibiting the activation of effector T cells in a subject by increasing or decreasing TNFR2 (CD 120b) signaling respectively. The present invention also relates to methods, compositions, and kits for treating diseases such as cancer, infections, and autoimmune diseases.
    Type: Application
    Filed: May 27, 2020
    Publication date: June 23, 2022
    Inventors: Edwin Hawkins, Najoua Lalaoui, Amanda Elizabeth Light, Mark McKenzie, John Silke
  • Fn14 Binding Proteins and Uses Thereof
    Publication number: 20200239586
    Abstract: The present disclosure provides proteins comprising antibody antigen binding domains that bind to Fn14 and uses thereof. The present disclosure also provides methods for treating wasting disorders, such as cachexia.
    Type: Application
    Filed: January 29, 2020
    Publication date: July 30, 2020
    Applicant: La Trobe University
    Inventors: Nicholas Johannes Hoogenraad, Amelia Jane Johnston, John Silke
  • Fn14 Binding Proteins and Uses Thereof
    Publication number: 20200002430
    Abstract: The present disclosure provides proteins comprising antibody antigen binding domains that bind to Fn14 and uses thereof. The present disclosure also provides methods for treating wasting disorders, such as cachexia.
    Type: Application
    Filed: March 22, 2019
    Publication date: January 2, 2020
    Applicant: La Trobe University
    Inventors: Nicholas Johannes Hoogenraad, Amelia Jane Johnston, John Silke
  • Fn14 binding proteins and uses thereof
    Patent number: 10287359
    Abstract: The present disclosure provides proteins comprising antibody antigen binding domains that bind to Fn14 and uses thereof. The present disclosure also provides methods for treating wasting disorders, such as cachexia.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: May 14, 2019
    Assignee: La Trobe University
    Inventors: Nicholas Johannes Hoogenraad, Amelia Jane Johnston, John Silke
  • Fn14 Binding Proteins and Uses Thereof
    Publication number: 20180057599
    Abstract: The present disclosure provides proteins comprising antibody antigen binding domains that bind to Fn14 and uses thereof. The present disclosure also provides methods for treating wasting disorders, such as cachexia.
    Type: Application
    Filed: October 23, 2017
    Publication date: March 1, 2018
    Applicant: La Trobe University
    Inventors: Nicholas Johannes Hoogenraad, Amelia Jane Johnston, John Silke
  • Fn14 Binding Proteins and Uses Thereof
    Publication number: 20170029519
    Abstract: The present disclosure provides proteins comprising antibody antigen binding domains that bind to Fn14 and uses thereof. The present disclosure also provides methods for treating wasting disorders, such as cachexia.
    Type: Application
    Filed: August 15, 2016
    Publication date: February 2, 2017
    Applicant: La Trobe University
    Inventors: Nicholas Johannes Hoogenraad, Amelia Jane Johnston, John Silke
  • Fn14 Binding Proteins and Uses Thereof
    Publication number: 20150218278
    Abstract: The present disclosure provides proteins comprising antibody antigen binding domains that bind to Fn14 and uses thereof. The present disclosure also provides methods for treating wasting disorders, such as cachexia.
    Type: Application
    Filed: October 31, 2014
    Publication date: August 6, 2015
    Applicant: TransBio Ltd
    Inventors: Nicholas Johannes Hoogenraad, Amelia Jane Johnston, John Silke
  • FN14 binding proteins and uses thereof
    Patent number: 9006397
    Abstract: The present disclosure provides proteins comprising antibody antigen binding domains that bind to Fn14 and uses thereof. The present disclosure also provides methods for treating wasting disorders, such as cachexia.
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: April 14, 2015
    Assignee: TransBio Ltd
    Inventors: Nicholas Johannes Hoogenraad, Amelia Jane Johnston, John Silke
  • Smac Mimetic Therapy
    Publication number: 20140303090
    Abstract: A Smac mimetic therapy wherein the Smac mimetic is selected and developed based at least in part on its poor inhibition of XIAP-dependent processes.
    Type: Application
    Filed: April 7, 2014
    Publication date: October 9, 2014
    Applicant: TETRALOGIC PHARMACEUTICALS CORPORATION
    Inventors: Stephen M. Condon, Srinivas K. Chunduru, Yasuhiro Mitsuuchi, James Vince, John Silke
  • Fn14 Binding Proteins and Uses Thereof
    Publication number: 20130273036
    Abstract: The present disclosure provides proteins comprising antibody antigen binding domains that bind to Fn14 and uses thereof. The present disclosure also provides methods for treating wasting disorders, such as cachexia.
    Type: Application
    Filed: March 27, 2013
    Publication date: October 17, 2013
    Applicant: TransBio Ltd
    Inventors: Nicholas Johannes Hoogenraad, Amelia Jane Johnston, John Silke
  • TNFalpha GENE EXPRESSION AS A BIOMARKER OF SENSITIVITY TO ANTAGONISTS OF INHIBITOR OF APOPTOSIS PROTEINS
    Publication number: 20110008802
    Abstract: TNF? gene expression can be used as a biomarker of a cell's sensitivity to antagonists of inhibitor of apoptosis proteins (IAPs). Methods of the invention are useful for screening patients to identify those who could benefit from administration of an IAP antagonist to treat various malignant or benign tumors, benign proliferative diseases, or autoimmune diseases.
    Type: Application
    Filed: May 7, 2008
    Publication date: January 13, 2011
    Applicant: TETRALOGIC PHARMACEUTICALS CORP.
    Inventors: Alireza Alavi, Mark A. McKinlay, Srinivas K. Chunduru, John Silke, David Vaux, James Vince