Abstract: A drug injection device includes a last dose setting having a main drive pin, a drive wheel, a driven wheel, an abutment element fixedly coupled to, or integrally formed with, the driven wheel. The drive wheel has a rotation axis parallel to a longitudinal axis and is configured to be driven about the longitudinal axis by a knob and to be periodically driven in rotation about the rotation axis by the main drive pin, during a drug dose setting. The driven wheel has a second rotation axis parallel or coaxial to said longitudinal axis and is configured to be periodically driven about the longitudinal axis by the drive wheel. The abutment element is configured to prevent the rotation of the drive wheel about the longitudinal axis when the knob has made a predetermined number of full and/or partial rotations about the longitudinal axis correlated to the predetermined drug volume.

Abstract: The invention relates to the use of a single heavy chain variable domain antibody against human cytomegalovirus protein US28, which antibody binds to the extracellular region including, for example, the N-terminal extracellular region and/or the extracellular loops of US28, for isolation of cells that are infected with cytomegalovirus and/or for ex vivo reactivation of cytomegalovirus in latently infected cells. The invention further relates to the anti-US28 antibody for use in a method of reactivating cytomegalovirus in infected cells, or in a method of eliminating infected cells. The invention further relates to a tissue, organ, or cells such as bone marrow stem cells, from which cells that were infected with CMV have been removed with the use of the anti-US28 antibody.

Abstract: A carriage arranged to walk along an elongate member while carrying a payload includes individually-operable clamps that are spaced axially along a common longitudinal axis. An axially-extensible frame connects the clamps. At least one of the clamps is attached to the frame via a rotationally-displaceable coupling for relative angular movement between that clamp and the frame about the longitudinal axis. The carriage can carry the payload to a subsea worksite by opening and closing the clamps to release and grip the elongate member in a sequence that includes moving the leading clamp forward when the leading clamp is open and moving the trailing clamp forward when the leading clamp is closed. At the worksite, installation force can be applied to the payload in a forward direction by moving the leading clamp forward when the leading clamp is open and the trailing clamp is closed.

Abstract: A carriage arranged to walk along an elongate member while carrying a payload includes individually-operable clamps that are spaced axially along a common longitudinal axis. An axially-extensible frame connects the clamps. At least one of the clamps is attached to the frame via a rotationally-displaceable coupling for relative angular movement between that clamp and the frame about the longitudinal axis. The carriage can carry the payload to a subsea worksite by opening and closing the clamps to release and grip the elongate member in a sequence that includes moving the leading clamp forward when the leading clamp is open and moving the trailing clamp forward when the leading clamp is closed. At the worksite, installation force can be applied to the payload in a forward direction by moving the leading clamp forward when the leading clamp is open and the trailing clamp is closed.

Abstract: A password breach registry is utilized to secure a service provided by a service provider. The password breach registry is a publicly accessible registry and includes password tokens written by breached service providers. The password tokens indicate passwords used to access breached service providers that may have been breached. A service provider can subscribe to the password breach registry and periodically query the password breach registry to determine if a password token corresponding to a user of a service provided by the service provider has been written to the password breach registry. This may indicate that the user of the service utilizes the same password on other services that have been breached. Upon determining that the password token has been written to the password breach registry, the user can be locked out from the service to prevent a malicious actor from gaining access to the account of the user.

Abstract: A registry is utilized to identify personally identifiable information (PII) that has been breached. The registry is a distributed database shared by multiple organizations to track which PII has been breached in other organizations. A first service provider initially receives PII and corresponding signed descriptor from a user. The PII is used to verify an identity of the user and the signed descriptor describes the type of PII that is received. The first service provider queries the registry to determine if the signed descriptor of the user has been written to the registry by a second service provider, indicating that it has been breached at a service provided by the second service provider. If the first service provider uses the breached PII, the breached PII is invalidated by the first service provider.

Abstract: A password breach registry is utilized to secure a service provided by a service provider. The password breach registry is a publicly accessible registry and includes password tokens written by breached service providers. The password tokens indicate passwords used to access breached service providers that may have been breached. A service provider can subscribe to the password breach registry and periodically query the password breach registry to determine if a password token corresponding to a user of a service provided by the service provider has been written to the password breach registry. This may indicate that the user of the service utilizes the same password on other services that have been breached. Upon determining that the password token has been written to the password breach registry, the user can be locked out from the service to prevent a malicious actor from gaining access to the account of the user.

Abstract: A method includes identifying a set of computing-resistant puzzles and receiving human-input proposed solutions to at least a subset of the puzzles. The method further includes confirming the validity of the human-input proposed solutions and producing a proof-of-work based on at least a threshold quantity of validated human-input proposed solutions. A new block including the produced proof-of-work is added to a blockchain database.

Abstract: A method includes obtaining a plurality of proof-of-stake blocks that include user data to be added to a blockchain database, and each of the proof-of-stake blocks is confirmed. In response to confirming each of the proof-of-stake blocks, each of the proof-of-stake blocks is added to the blockchain database. The method further includes obtaining a proof-of-work block that includes a representation of each of the proof-of-stake blocks added to the blockchain database and confirming the proof-of-work block. In response to confirming the proof-of-work block, the method adds the proof-of-work block to the blockchain database.

Abstract: A method includes distributing a plurality of key pieces associated with an encryption key to a plurality of key piece holders, adding release data to a blockchain database including sensitive data encrypted with the encryption key and a specified release date. The method further includes providing instructions to key piece holders to add respective key pieces to the blockchain database at the specified release date to facilitate time-based release of the sensitive data.

Abstract: A registry is utilized to identify personally identifiable information (PII) that has been breached. The registry is a distributed database shared by multiple organizations to track which PII has been breached in other organizations. A first service provider initially receives PII and corresponding signed descriptor from a user. The PII is used to verify an identity of the user and the signed descriptor describes the type of PII that is received. The first service provider queries the registry to determine if the signed descriptor of the user has been written to the registry by a second service provider, indicating that it has been breached at a service provided by the second service provider. If the first service provider uses the breached PII, the breached PII is invalidated by the first service provider.

Abstract: A password breach registry is utilized to secure a service provided by a service provider. The password breach registry is a publicly accessible registry and includes password tokens written by breached service providers. The password tokens indicate passwords used to access breached service providers that may have been breached. A service provider can subscribe to the password breach registry and periodically query the password breach registry to determine if a password token corresponding to a user of a service provided by the service provider has been written to the password breach registry. This may indicate that the user of the service utilizes the same password on other services that have been breached. Upon determining that the password token has been written to the password breach registry, the user can be locked out from the service to prevent a malicious actor from gaining access to the account of the user.

Abstract: A registry is utilized to identify personally identifiable information (PII) that has been breached. The registry is a distributed database shared by multiple organizations to track which PII has been breached in other organizations. A first service provider initially receives PII and corresponding signed descriptor from a user. The PII is used to verify an identity of the user and the signed descriptor describes the type of PII that is received. The first service provider queries the registry to determine if the signed descriptor of the user has been written to the registry by a second service provider, indicating that it has been breached at a service provided by the second service provider. If the first service provider uses the breached PII, the breached PII is invalidated by the first service provider.

Abstract: A submersible mixing and sampling apparatus with submersible supply systems (12, 14) for first and second liquid components such as a thermoset resin and a curing agent is disclosed. Each supply system has a respective submersible tank (24) for holding a respective one of the liquid components. Submersible mixers (46, 48, 50) downstream of the supply systems mix the liquid components underwater to form a curable mixture for injection into a subsea chamber such as a tee (102). Submersible sampling devices downstream of the mixers take samples (94) of the mixture underwater before, during and after injection, and optionally also at the surface. The samples may be cured and tested underwater or may be lifted to the surface for testing. The apparatus may be mounted on a subsea skid (100) or basket.

Abstract: In a computer-implemented method for endpoint management, a plurality of messages communicated between a target endpoint and a client are recorded, in a computer-readable memory. Ones of the messages are clustered into respective groups, where the respective groups correspond to respective operation types of the ones of the messages included therein. For the respective operation types, respective message structures used by the target endpoint are determined based on commonalities among the ones of the messages of the respective groups corresponding to the operation types. For one of the respective operation types, a request to the target endpoint is generated in accordance with a corresponding one of the respective message structures used by the target endpoint. Related computer systems and computer program products are also discussed.

Abstract: A carriage arranged to walk along an elongate member while carrying a payload includes individually-operable clamps that are spaced axially along a common longitudinal axis. An axially-extensible frame connects the clamps. At least one of the clamps is attached to the frame via a rotationally-displaceable coupling for relative angular movement between that clamp and the frame about the longitudinal axis. The carriage can carry the payload to a subsea worksite by opening and closing the clamps to release and grip the elongate member in a sequence that includes moving the leading clamp forward when the leading clamp is open and moving the trailing clamp forward when the leading clamp is closed. At the worksite, installation force can be applied to the payload in a forward direction by moving the leading clamp forward when the leading clamp is open and the trailing clamp is closed.

Abstract: A registry is utilized to identify personally identifiable information (PII) that has been breached. The registry is a distributed database shared by multiple organizations to track which PII has been breached in other organizations. A first service provider initially receives PII and corresponding signed descriptor from a user. The PII is used to verify an identity of the user and the signed descriptor describes the type of PII that is received. The first service provider queries the registry to determine if the signed descriptor of the user has been written to the registry by a second service provider, indicating that it has been breached at a service provided by the second service provider. If the first service provider uses the breached PII, the breached PII is invalidated by the first service provider.

Abstract: A password breach registry is utilized to secure a service provided by a service provider. The password breach registry is a publicly accessible registry and includes password tokens written by breached service providers. The password tokens indicate passwords used to access breached service providers that may have been breached. A service provider can subscribe to the password breach registry and periodically query the password breach registry to determine if a password token corresponding to a user of a service provided by the service provider has been written to the password breach registry. This may indicate that the user of the service utilizes the same password on other services that have been breached. Upon determining that the password token has been written to the password breach registry, the user can be locked out from the service to prevent a malicious actor from gaining access to the account of the user.

Abstract: A carriage arranged to walk along elongate member while carrying a payload includes individually-operable clamps that are spaced axially along a common longitudinal axis. An axially-extensible frame connects the clamps. At least one of the clamps is attached to the frame via a rotationally-displaceable coupling for relative angular movement between that clamp an the frame about the longitudinal axis. The carriage can carry the payload to a subsea worksite by opening and closing the clamps to release and grip the elongate member in a sequence that includes moving the leading clamp forward when the leading clamp is open and moving the trailing clamp forward when the leading clamp is closed. At the worksite, installation force can be applied to the payload in a forward direction by moving the leading clamp forward when the leading clamp is open and the trailing clamp is closed.

Abstract: A registry is utilized to identify personally identifiable information (PII) that has been breached. The registry is a distributed database shared by multiple organizations to track which PII has been breached in other organizations. A first service provider initially receives PII and corresponding signed descriptor from a user. The PII is used to verify an identity of the user and the signed descriptor describes the type of PII that is received. The first service provider queries the registry to determine if the signed descriptor of the user has been written to the registry by a second service provider, indicating that it has been breached at a service provided by the second service provider. If the first service provider uses the breached PII, the breached PII is invalidated by the first service provider.