Abstract: The invention relates to the use of a single heavy chain variable domain antibody against human cytomegalovirus protein US28, which antibody binds to the extracellular region including, for example, the N-terminal extracellular region and/or the extracellular loops of US28, for isolation of cells that are infected with cytomegalovirus and/or for ex vivo reactivation of cytomegalovirus in latently infected cells. The invention further relates to the anti-US28 antibody for use in a method of reactivating cytomegalovirus in infected cells, or in a method of eliminating infected cells. The invention further relates to a tissue, organ, or cells such as bone marrow stem cells, from which cells that were infected with CMV have been removed with the use of the anti-US28 antibody.

Abstract: The present invention includes a system and process to visualize an event. The event visualization includes one or more physical entities that generate data experienced thereby and generate executable files related to their vantage points. A file manipulation engines normalizes data both existing in pure data form as well as data within the executable files. A visual display renders a representation of the data along with executable files that are correlated to the data. A relationship between two or more physical entities may be determined, and multimedia files of one entity that includes the other may be determined. Entities with no relationship between them, other than physical proximity (or other relationship) at a particular time, may offer multimedia files to the other entity that includes that entity.

Abstract: The present invention includes a system and process to visualize an event. The event visualization includes one or more physical entities that generate data experienced thereby and generate executable files related to their vantage points. A file manipulation engines normalizes data both existing in pure data form as well as data within the executable files. A visual display renders a representation of the data along with executable files that are correlated to the data. A relationship between two or more physical entities may be determined, and multimedia files of one entity that includes the other may be determined. Entities with no relationship between them, other than physical proximity (or other relationship) at a particular time, may offer multimedia files to the other entity that includes that entity.

Abstract: The present invention includes a system and process to visualize an event. The event visualization includes one or more physical entities that generate data experienced thereby and generate executable files related to their vantage points. A file manipulation engines normalizes data both existing in pure data form as well as data within the executable files. A visual display renders a representation of the data along with executable files that are correlated to the data.

Abstract: This invention relates to a non-coding RNA (ncRNA) sequence from Human cytomegalovirus (HCMV) (termed “TRL4”) that specifically protects neuronal cells from cell death and may therefore be useful in the treatment of neurodegenerative disorders, such as Parkinson's disease.

Abstract: A method for conducting an e-mail campaign is provided. The method includes the steps of: (a) sending e-mails to a plurality of intended recipients; (b) determining a number of the e-mails that have been indicated as nondeliverable; (c) determining a number of the e-mails that have been identified as bulk and not delivered to the intended recipients; (d) determining, from the determinations made in steps (b) and (c), a number of the e-mails that have reached the intended recipients; and (e) billing only for the number of e-mails determined in step (d).

Abstract: Protein structures 1 repeating regularly in one, two or three dimensions comprise protein protomers 2 which each comprise at least two monomers 5, 6 genetically fused together. The monomers 5, 6 are monomers of respective oligomer assemblies 3, 4 into which the monomers are assembled to assembly of the protein structure. The first oligomer assembly 3 has rotational symmetry axes including a set of rotational symmetry axes of order N, where N equals 2, 3, 4 or 6. The second oligomer assembly 4 has a rotational symmetry axis of the same order N as said set of rotational symmetry axes of said first oligomer assembly 3. Due to the symmetry of the oligomer assemblies 3, 4, the rotational symmetry axis axes of each second oligomer assembly 4 is aligned with one of said set of rotational symmetry axes of a first oligomer assembly 3 with N protomers being arranged symmetrically therearound.

Abstract: A communication and control system for use by the disabled and their caretakers. The system has at least two communication modules, each module having a processing unit which has a unique identification code. Each communication module also has a unique hierarchical address corresponding to the identification code, the address defining the physical location of the module. The hierarchical address represents at least two physical domains. Each commnunication module further includes a processing unit having coupled to it one or both of a signal receiver and a signal transmitter, and at least one transducer for detecting a physical parameter and for broadcasting packets of data indicative of the status of a module or for controlling a remote module.

Abstract: Protein lattice (1) having a regular structure with a repeating unit repeating in three dimensions may have many uses, for example to support an array of macromolecular entities for x-ray crystallography. The repeating unit comprises protein protomers (2) which each comprise at least two monomers (5, 6) fused together. The monomers (5, 6) are each monomers of a respective oligomer assembly (3, 4) into which the monomers are assembled for assembly of the protomers into the lattice. The first oligomer assembly (3) has a set of rotational symmetry axes extending in three dimensions. In said protomers (2), further monomers (6) fused to said first monomers (5) are monomers of respective further oligomer assemblies (4) which have a rotational symmetry axis of the same order as a respective one of said set of rotational symmetry axes of said first oligomer assembly (3).

Abstract: A method for treating eating disorders by repeatedly administering naloxone in a dosage sufficient to block the effects of opiate agonists to a subject suffering from an eating disorder caused by one or more related problem responses; while the amount of naloxone in the subject's body is sufficient to block opiate effects, having the subject make one of the problem responses from which the subject suffers in the presence of stimuli similar to those to which it had been learned, after the amount of naloxone is no longer sufficient to block opiate effects, having the subject make healthy eating responses to food items that do not trigger the problem responses; and continuing the steps of administration of naloxone and having one after another of the problem responses made, followed by having a naloxone-free period in which healthy eating occurs, until the problem responses are extinguished.

Abstract: An elongate electrical conductor (2) is disclosed that is adapted for electrically connecting with an electrical contact, the conductor (2) includes a longitudinally extending elongate body (61) for defining a first contact surface (62); and a plurality of longitudinally spaced apart ribs (66) that extend from the body (61) to respective free ends (67) that are spaced apart from the first contact surface (62) for allowing the contact to be progressed between the body (61) and one or more of the ribs (66), each rib (66) including a respective second contact surface (68) that is opposed with the first surface (62) wherein, upon progression of the contact between the body (61) and the one or more ribs (66), the first surface (62) and the respective one or more second surfaces (68) are resiliently biased into engagement with the contact.

Abstract: An apparatus method and system are described for categorising Uniform Resource Locators (URLs) when accessing the Internet 20 from a client 12. A request message 500 is generated to request categorisation of a specified URL, and a category is provided in a reply message 600. The specified URL and the category are added to a category cache. In a second or subsequent instance of a URL request referring to the specified URL, the category is determined from the category cache. This reduces communication traffic in a network such as the Internet 20.

Abstract: A system method and apparatus are provided for use in monitoring or controlling internet access at a client device 12. A request message 500 is generated to request categorisation of a specified URL, and a reply message 600 is returned denoting a category of the specified URL amongst a predetermined set of categories. The request message 500 comprises a UDP package including a sequence number, a time stamp, and a data section carrying the specified URL. The reply message 600 comprises a UDP packet and includes the sequence number and the time stamp from the request message 500, and a data section identifying the category. The request message 500 and the reply message 600 are economical and provide efficient communication across a local area network or the Internet 20.

Abstract: An apparatus, method and system for use in categorising Uniform Resource Locators (URLs) when controlling or monitoring access to the Internet 20 from a client 12. A request message 500 is generated to request categorisation of a specified URL. The request message 500 comprises a licensing field carrying a licence key. A remote server 40 receives the licence key and, if valid, generates a reply message 600 denoting a category of the specified URL. The licence key enables workload at the server 40 to be managed efficiently.

Abstract: A communication and control system particularly for use by the disabled, and carers of the disabled, in a domestic environment is described. The communication and control system has at least two communication modules, each module having a processing unit which has a unique identification code. Each communication module also has a unique hierarchical address corresponding to the identification code, the address defining the physical location of the module. The hierarchical address represents at least two physical domains. Each processing unit has coupled to it a signal receiver or a signal transmitter or both a signal receiver and a signal transmitter, and at least one transducer for detecting a physical parameter and for broadcasting packets of data indicative of the status of a module or for controlling a remote module.

Abstract: An aspartic acid rich protein isolated from human urine, as well as proteins having substantial homology thereto and active portions of the foregoing are effective modulators of mineralization in mammals. These proteins and peptides are useful as therapeutic agents, such as in the treatment of kidney stone disease. Hybridoma cell lines capable of producing monoclonal antibodies to these proteins and peptides and monoclonal antibodies produced by these hybridomas are disclosed. These monoclonal antibodies are also useful as therapeutic agents, such as in the treatment of osteoporosis, and further have utility as diagnostic agents. Other uses are also described.