Abstract: The present invention provides a compound of formula (I), or pharmaceutically acceptable salt or solvate thereof, wherein: Y is selected from C or N; X is O; bond a is a single or double bond; x is 1 when a is a single bond and x is 0 when a is a double bond; R1 is selected from hydrogen and methyl; R2 (when present) is selected from hydrogen and methyl; R3 is selected from hydrogen, (1-6C)alkyl and (1-6C)alkyl-phenyl, wherein said phenyl is optionally substituted by one or more (for example 1 to 3) substituents each independently selected from hydroxy, (1-6C)alkoxy, (1-6C)alkyl and halo (such as chloro and fluoro).

Abstract: The present invention provides a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein: Y is selected from C or N; X is selected from O or S; R1 is selected from hydrogen or methyl; Z is CR2R3, wherein R2 and R3 are each independently selected from hydrogen and (1-5C)alkyl, or R2 and R3 are taken together with the carbon atom to which they are attached to form a cyclopropyl or cyclobutyl ring; Z1 is selected from CR4R5, O, S, C(O) or NR6, wherein R4 and R5 are each independently selected from hydrogen, OH, (1-5C)alkyl and phenyl, or R4 and R5 are taken together with the carbon atom to which they are attached to form a cyclopropyl ring, and R6 is selected from hydrogen and (1-5C)alkyl, provided that one, but not both, of Z and Z1 is CH2.

Abstract: The present invention provides a compound of formula (I), or pharmaceutically acceptable salt or solvate thereof, wherein: Y is selected from C or N; X is O; bond a is a single or double bond; x is 1 when a is a single bond and x is 0 when a is a double bond; R1 is selected from hydrogen and methyl; R2 (when present) is selected from hydrogen and methyl; R3 is selected from hydrogen, (1-6C)alkyl and (1-6C)alkyl-phenyl, wherein said phenyl is optionally substituted by one or more (for example 1 to 3) substituents each independently selected from hydroxy, (1-6C)alkoxy, (1-6C)alkyl and halo (such as chloro and fluoro).

Abstract: Disclosed herein are methods, systems, and processes to perform self-dependent upgrades of Java Runtime Environments (JREs). A request to update a plugin to a new version with a new configuration that includes a location to download a new upgrader-executable is received from a platform computing device at an endpoint computing device. The plugin is uploaded to the new version. The new upgrader-executable that includes an executable with an executable table executed by the plugin is downloaded from the location. The executable is used to halt execution of a JRE application (e.g., a Collector) and download JRE files required for the upgrade. The JRE application (e.g., the Collector) is then re-started with the new configuration, which can be rolled back if the upgrade is unsuccessful.

Abstract: Disclosed herein are methods, systems, and processes to perform self-dependent upgrades of Java Runtime Environments (JREs). A request to update a plugin to a new version with a new configuration that includes a location to download a new upgrader-executable is received from a platform computing device at an endpoint computing device. The plugin is uploaded to the new version. The new upgrader-executable that includes an executable with an executable table executed by the plugin is downloaded from the location. The executable is used to halt execution of a JRE application (e.g., a Collector) and download JRE files required for the upgrade. The JRE application (e.g., the Collector) is then re-started with the new configuration, which can be rolled back if the upgrade is unsuccessful.