Abstract: Cryogenic methods, systems, and devices cryogenic system for alleviating lower back pain in a patient. The cryogenic device includes a handpiece having a size and shape suitable for supporting in a hand of an operator and a needle probe coupled to a distal portion of the handpiece. The needle probe includes a probe body, at least one needle coupled to the probe body, and a silica supply tube extending within the needle lumen. The system includes an introducer configured to receive and position the at least one needle proximate to a location of a target tissue associated with lower back pain, wherein the cryogenic device is configured to provide a desired ice ball shape that remains on a distal portion of the introducer after the at least one needle is removed therefrom. The system further includes a needle guard configured to house the needle probe.

Abstract: Cryogenic methods, systems, and devices cryogenic system for alleviating lower back pain in a patient. The cryogenic device includes a handpiece having a size and shape suitable for supporting in a hand of an operator and a needle probe coupled to a distal portion of the handpiece. The needle probe includes a probe body, at least one needle coupled the probe body, and a silica supply tube extending within the needle lumen. The system includes an introducer configured to receive and position the at least one needle proximate to a location of a target tissue associated with lower back pain, wherein the cryogenic device is configured to provide a desired ice ball shape that remains on a distal portion of the introducer after the at least one needle is removed therefrom. The system further includes a needle guard configured to house the needle probe.

Abstract: A method of interrupting sympathetic stimulation to the cardiovascular system of a patient in need thereof includes navigating a probe of a hand-held cryogenic therapy apparatus to a stellate ganglion or an autonomic tissue area peripheral to the stellate ganglion of the patient, the probe including a needle configured to produce a cooling zone for focused cryogenic therapy, aligning the needle with one or more desired nerves of the stellate ganglion or the autonomic tissue area peripheral to the stellate ganglion, and producing the cooling zone to provide cryogenic therapy to the desired nerves of the stellate ganglion or the autonomic tissue area peripheral to the stellate ganglion at a temperature sufficient to cause axonotmesis of the nerves.

Abstract: Embodiments of the present disclosure relate to methods of using bupivacaine multivesicular liposomes (MVLs) as stellate ganglion block (SGB) for treating or ameliorating a sympathetic nervous system disorder associated with overactive or unbalanced sympathetic nervous system, including but not limited to, Raynaud's syndrome, post-mastectomy pain, reflex sympathetic dystrophy (RSD), phantom limb pain, hyperhidrosis, trigeminal neuralgia/facial pain, scleroderma, and long COVID.

Abstract: Embodiments of the present disclosure relate to methods of using bupivacaine multivesicular liposomes as stellate ganglion block for treating or ameliorating an anxiety disorder or a traumatic brain injury associated with overactive or unbalanced sympathetic nervous system, including but not limited to, generalized anxiety disorders, panic disorder, and post-traumatic stress disorder.

Abstract: Embodiments of the present disclosure relate to the use of bupivacaine multivesicular liposomes (MVLs) as stellate ganglion block (SGB) for treating or ameliorating various diseases and conditions, including but not limited to cardiac electrical storm or cardiac arrythmia/dysrhythmia following heart surgery.

Abstract: A method of interrupting sympathetic stimulation to the cardiovascular system of a patient in need thereof includes navigating a probe of a hand-held cryogenic therapy apparatus to a stellate ganglion or an autonomic tissue area peripheral to the stellate ganglion of the patient, the probe including a needle configured to produce a cooling zone for focused cryogenic therapy, aligning the needle with one or more desired nerves of the stellate ganglion or the autonomic tissue area peripheral to the stellate ganglion, and producing the cooling zone to provide cryogenic therapy to the desired nerves of the stellate ganglion or the autonomic tissue area peripheral to the stellate ganglion at a temperature sufficient to cause axonotmesis of the nerves.