Abstract: Anti-cancer immune-stimulating therapies have shown inconsistent results when used in humans. The present disclosure provides methods of using eosinophil-depleting agents to increase the therapeutic activity of anti-cancer immune-stimulating therapies. The present disclosure also provides methods of identifying subjects susceptible to respond to anti-cancer immune-stimulating therapies based on their ability to reduce the number of tumor regulatory T cells.

Abstract: In one example, the present disclosure describes a device, computer-readable medium, and method for providing smart mobility assistance. For instance, in one example, a device includes a set of sensors, a processor, a first set of feedback mechanisms, and a communication device. The set of sensors is to monitor an area surrounding a user of a mobility assistance device. The processor is to detect a hazard in the surrounding area, based on the monitoring. The first set of feedback mechanisms is to provide the user with an alert that notifies the user of the hazard. The communication device is to send a notification to a third party informing the third party of the hazard.

Abstract: In one example, the present disclosure describes a device, computer-readable medium, and method for providing smart mobility assistance. For instance, in one example, a device includes a set of sensors, a processor, a first set of feedback mechanisms, and a communication device. The set of sensors is to monitor an area surrounding a user of a mobility assistance device. The processor is to detect a hazard in the surrounding area, based on the monitoring. The first set of feedback mechanisms is to provide the user with an alert that notifies the user of the hazard. The communication device is to send a notification to a third party informing the third party of the hazard.

Abstract: In one example, the present disclosure describes a device, computer-readable medium, and method for providing smart mobility assistance. For instance, in one example, a device includes a set of sensors, a processor, a first set of feedback mechanisms, and a communication device. The set of sensors is to monitor an area surrounding a user of a mobility assistance device. The processor is to detect a hazard in the surrounding area, based on the monitoring. The first set of feedback mechanisms is to provide the user with an alert that notifies the user of the hazard. The communication device is to send a notification to a third party informing the third party of the hazard.

Abstract: An accessory for supporting a handheld electronic device includes a bistable spring to position and support the handheld device. The accessory includes a housing coupled to the handheld device and a bistable spring moveable between a first position and a second position. In the first position the bistable spring is substantially flat and in the second position the bistable spring defines a longitudinal curve away from the housing. The curvature of the bistable spring in the second position can support the handheld device on a surface e.g. table and in a slot such as CD player or air vent in a vehicle. The longitudinal curve of the bistable spring easily deflects to a reduced curvature to be received in and retained with a slot and consistently actuates to same radius in the second position providing proper viewing angle of screen for handheld device.

Abstract: A coffee product and process are provided which produce a coffee product having elevated levels of 3,7-dimethylocta-1,6-dien-3-ol. In various forms, the coffee product is dry roast and ground coffee or a dry soluble coffee product such as a powder or granule form. The process includes adding 3,7-dimethylocta-1,6-dien-3-ol to roast and ground coffee or a soluble coffee to produce an enhanced coffee flavor beverage, or to an extract or solution thereof.

Abstract: A coffee product and process are provided which produce a coffee product having elevated levels of 3,7-dimetylocta-1,6-dien-3-ol. In various forms, the coffee product is dry roast and ground coffee or a dry soluble coffee product such as a powder or granule form. The process includes adding 3,7-dimethylocta-1,6-dien-3-ol to roast and ground coffee or a soluble coffee to produce an enhanced coffee flavor beverage, or to an extract or solution thereof.

Abstract: There is provided a stromal antigen-presenting cell capable of antigen presentation in the context of MHC II. When stimulated with IFN? the stromal cell expresses B7-H1 and/or CD80. These stromal cells can be used to generate an immune response in an animal.

Abstract: There is provided a stromal antigen-presenting cell capable of antigen presentation in the context of MHC II. When stimulated with IFN? the stromal cell expresses B7-H1 and/or CD80. These stromal cells can be used to generate an immune response in an animal.

Abstract: The present invention relates to an immuno-therapy conjugate which comprises A-c-B wherein: A and B are different and are compounds selected from the group consisting of cytokines, chemokines, interferons, their respective receptors or a functional fragment thereof; and c is a linker consisting of a bond or an amino acid sequence containing from 1 to 100 residues. The present invention also relates to a vaccine adjuvant comprising the immuno-therapy conjugate of the present invention. The present invention further relates to a method of reducing tumor growth, for inhibiting a viral infection and for improving immune response in a patient.

Abstract: The present invention relates to genetically-engineered bone marrow stromal cells and method of preparation thereof for ex vivo delivery of protein and peptides of interest into human or animals. The method includes forming a bone marrow stromal cell expression system in vitro and administering the expression system to a human or animal recipient. The invention relates also to implants colonized by bone marrow stromal cells. In accordance with the invention, the implants comprise a matrix which can be composed of a large variety of biocompatible and biodegradable products, and stromal cells which are integrated into the matrix as such or under genetically-engineered forms. Genetically-engineered bone marrow stromal cells or cell colonized implant are also useful for tissue repair and tissue synthesis, as for angiogenesis.