Abstract: The present invention provides, among other things, methods of engineering a re-editable target locus in a cell, comprising inserting an exogenous re-editable template sequence to a target locus and methods of engineering a re-editable cell comprising a re-editable template sequence flanked by two homology arms such that the re-editable template sequence is inserted into a target locus by homologous recombination, and methods of using the same. In some aspects, provided is a re-editable template sequence, wherein the template sequence has no substantial sequence similarity to any region in the genome, and wherein the template sequence is recognizable by a genome editing system.

Abstract: Included are systems and methods for providing insurer risk data. Some of the methods include receiving insurance data related to an insurer and determining a captured risk score from the insurance data, the captured risk score being determined by a predetermined calculation. Some of the methods include determining a gap risk score from the insurance data, where the gap risk score being determined from a proprietary calculation that is different than the predetermined calculation, and where the gap risk score identifying a second criteria that was not identified in the captured risk score and the qualifies the insurer for an additional compensation. Some of the methods include providing a user interface that includes data related to the captured risk score and the gap risk score.

Abstract: Included are systems and methods for providing insurer risk data. Some of the methods include receiving insurance data related to an insurer and determining a captured risk score from the insurance data, the captured risk score being determined by a predetermined calculation. Some of the methods include determining a gap risk score from the insurance data, where the gap risk score being determined from a proprietary calculation that is different than the predetermined calculation, and where the gap risk score identifying a second criteria that was not identified in the captured risk score and the qualifies the insurer for an additional compensation. Some of the methods include providing a user interface that includes data related to the captured risk score and the gap risk score.

Abstract: This disclosure relates generally to a computing system and method for data encryption and, more particularly, to methods and apparatus for enhanced protection of data transmitted to and from, as well as stored on file systems associated with an internet service application using integrated mechanisms and processes for data obscurity, secure sleep state encryption, and separation of concerns.

Abstract: Included are systems and methods for providing insurer risk data. Some of the methods include receiving insurance data related to an insurer and determining a captured risk score from the insurance data, the captured risk score being determined by a predetermined calculation. Some of the methods include determining a gap risk score from the insurance data, where the gap risk score being determined from a proprietary calculation that is different than the predetermined calculation, and where the gap risk score identifying a second criteria that was not identified in the captured risk score and the qualifies the insurer for an additional compensation. Some of the methods include providing a user interface that includes data related to the captured risk score and the gap risk score.

Abstract: Method and apparatus for generating a low tar, renewable fuel gas from biomass and using it in other energy conversion devices, many of which were designed for use with gaseous and liquid fossil fuels. An automated, downdraft gasifier incorporates extensive air injection into the char bed to maintain the conditions that promote the destruction of residual tars. The resulting fuel gas and entrained char and ash are cooled in a special heat exchanger, and then continuously cleaned in a filter prior to usage in standalone as well as networked power systems.

Abstract: A method and apparatus for removing fine particulate matter from a fluid stream without interrupting the overall process or flow. The flowing fluid inflates and expands the flexible filter, and particulate is deposited on the filter media while clean fluid is permitted to pass through the filter. This filter is cleaned when the fluid flow is stopped, the filter collapses, and a force is applied to distort the flexible filter media to dislodge the built-up filter cake. The dislodged filter cake falls to a location that allows undisrupted flow of the fluid after flow is restored. The shed particulate is removed to a bin for periodic collection. A plurality of filter cells can operate independently or in concert, in parallel, or in series to permit cleaning the filters without shutting off the overall fluid flow. The self-cleaning filter is low cost, has low power consumption, and exhibits low differential pressures.

Abstract: Method and apparatus for generating a low tar, renewable fuel gas from biomass and using it in other energy conversion devices, many of which were designed for use with gaseous and liquid fossil fuels. An automated, downdraft gasifier incorporates extensive air injection into the char bed to maintain the conditions that promote the destruction of residual tars. The resulting fuel gas and entrained char and ash are cooled in a special heat exchanger, and then continuously cleaned in a filter prior to usage in standalone as well as networked power systems.

Abstract: A method and apparatus for removing fine particulate matter from a fluid stream without interrupting the overall process or flow. The flowing fluid inflates and expands the flexible filter, and particulate is deposited on the filter media while clean fluid is permitted to pass through the filter. This filter is cleaned when the fluid flow is stopped, the filter collapses, and a force is applied to distort the flexible filter media to dislodge the built-up filter cake. The dislodged filter cake falls to a location that allows undisrupted flow of the fluid after flow is restored. The shed particulate is removed to a bin for periodic collection. A plurality of filter cells can operate independently or in concert, in parallel, or in series to permit cleaning the filters without shutting off the overall fluid flow. The self-cleaning filter is low cost, has low power consumption, and exhibits low differential pressures.

Abstract: Method and apparatus for generating a low tar, renewable fuel gas from biomass and using it in other energy conversion devices, many of which were designed for use with gaseous and liquid fossil fuels. An automated, downdraft gasifier incorporates extensive air injection into the char bed to maintain the conditions that promote the destruction of residual tars. The resulting fuel gas and entrained char and ash are cooled in a special heat exchanger, and then continuously cleaned in a filter prior to usage in standalone as well as networked power systems.

Abstract: A method and apparatus for removing fine particulate matter from a fluid stream without interrupting the overall process or flow. The flowing fluid inflates and expands the flexible filter, and particulate is deposited on the filter media while clean fluid is permitted to pass through the filter. This filter is cleaned when the fluid flow is stopped, the filter collapses, and a force is applied to distort the flexible filter media to dislodge the built-up filter cake. The dislodged filter cake falls to a location that allows undisrupted flow of the fluid after flow is restored. The shed particulate is removed to a bin for periodic collection. A plurality of filter cells can operate independently or in concert, in parallel, or in series to permit cleaning the filters without shutting off the overall fluid flow. The self-cleaning filter is low cost, has low power consumption, and exhibits low differential pressures.

Abstract: Compounds of formula (1), pharmaceutically acceptable salts, solvates and in vivo hydrolysable esters thereof, have activity as pharmaceuticals, in particular as modulators of chemokine receptor (especially CXCR2) activity, and may be in the treatment (therapeutic or prophylactic) of conditions/diseases in human and non-human animals which are exacerbated or caused by excessive or unregulated production of chemokines.

Abstract: The invention provides N-pyrazinyl-thienylsulphonamides of formula (I) for use in the treatment of chemokine mediated diseases.

Abstract: A universal output control system and method for outputting an output job at a target output location wherein a universal user interface facilitates access to and control of a plurality of output devices located on a network or at an output center such that specific details of each output device are encapsulated. The universal user interface provides searches of available output devices in a network, wherein printer drivers are automatically installed as needed. Alternatively, an output management application service stores an output job until output job data is generated for controlling the output of the output job on the selected output device, at which time the output job is output on the selected output device per the output job data. If the target output location is an output device on a network, an output device database service captures and generates the output job data.

Abstract: An antimicrobial coating slurry includes about 15.5 wt % of a wetting agent, about 6.0 wt % of an insolubilizer, about 1.1 wt % of a biocide agent, and about 7.8 wt % of an inorganic material that includes lithium oxide and the balance water. The slurry is applied to a heat exchanger surface, cured, and washed to form a hydrophilic coating that includes lithium silicate. The hydrophilic coating provides improved moisture wicking and a reduced dissolution rate of biocide, which is held within a lithium silicate matrix.

Abstract: A chemical concentration control arrangement includes two sorbent beds that cooperate to control a chemical concentration in a fluid. One of the sorbent beds selectively removes the chemical to reduce the concentration and the other sorbent bed selectively releases the chemical to increase the concentration. In a cooling system, the sorbent beds are used to control a biocide concentration in circulating coolant.

Abstract: A method and apparatus for removing fine particulate matter from a fluid stream without interrupting the overall process or flow. The flowing fluid inflates and expands the flexible filter, and particulate is deposited on the filter media while clean fluid is permitted to pass through the filter. This filter is cleaned when the fluid flow is stopped, the filter collapses, and a force is applied to distort the flexible filter media to dislodge the built-up filter cake. The dislodged filter cake falls to a location that allows undisrupted flow of the fluid after flow is restored. The shed particulate is removed to a bin for periodic collection. A plurality of filter cells can operate independently or in concert, in parallel, or in series to permit cleaning the filters without shutting off the overall fluid flow. The self-cleaning filter is low cost, has low power consumption, and exhibits low differential pressures.

Abstract: Method and apparatus for generating a low tar, renewable fuel gas from biomass and using it in other energy conversion devices, many of which were designed for use with gaseous and liquid fossil fuels. An automated, downdraft gasifier incorporates extensive air injection into the char bed to maintain the conditions that promote the destruction of residual tars. The resulting fuel gas and entrained char and ash are cooled in a special heat exchanger, and then continuously cleaned in a filter prior to usage in standalone as well as networked power systems.

Abstract: A method, and a system using the method, of managing a scanned document. The method includes identifying information of a profile for the scanned document and generating a virtual coversheet based on the identified information of the profile. The method also includes associating the virtual coversheet with the scanned document.

Abstract: A method, and a system using the method, of managing and using a profile to be associated with a document. The method includes generating an identifier based on the profile and printing the identifier for use in scanning documents to be associated with the profile.