Abstract: Ursodeoxycholic acid (UDCA) is a bile acid with demonstrated anti-apoptotic activity in both in vitro and in vivo models. Water-soluble prodrugs of UDCA for use in indications where intravenous administration of UDCA may be preferable, such as reducing damage from stroke or acute kidney injury, are disclosed. The disclosed prodrugs showed significant anti-apoptotic activity in a series of in vitro assays.

Abstract: Ursodeoxycholic acid (UDCA) is a bile acid with demonstrated anti-apoptotic activity in both in vitro and in vivo models. Water-soluble prodrugs of UDCA for use in indications where intravenous administration of UDCA may be preferable, such as reducing damage from stroke or acute kidney injury, are disclosed. The disclosed prodrugs showed significant anti-apoptotic activity in a series of in vitro assays.

Abstract: A magnet structure for use with a loudspeaker may have an interlocking mechanism. The magnet structure may include a magnet, a shell pot and a core cap. The shell pot may contain the magnet in its hollow interior. The magnet may be a single magnet or double magnets. The core cap has two surfaces. For a single magnet, one surface of the core cap may face a magnet. For double magnets, the core cap may be vertically disposed between the two magnets. The magnet, the core cap and the shell pot may interlock with one another such that a position of the magnet relative to the core cap and the shell pot may be rigidly preserved. The magnet may be configured to be, for example, overlapped, inserted, staked and/or engaged with at least one of the shell pot or the core cap.

Abstract: A planar loudspeaker includes a shell pot, a magnet, a diaphragm, and a face plate. The magnet may be positioned in a cavity in the shell pot. The diaphragm may be coupled with the shell pot to cover an entrance to the cavity. The shell pot may include a conductive path having an inner contact proximate the central axis of the diaphragm, and an outer contact proximate to a perimeter of the diaphragm. The face plate may be coupled with the shell pot so that the diaphragm is positioned between the magnet and the faceplate. The face plate may include an inner terminal and an outer terminal that are aligned to be in direct contact with the respective inner contact and the outer contact of the diaphragm and form an electrical connection there between when the face plate is coupled with the shell pot. The inner and outer terminals may be coupled with a source of electrical signals, such as an audio amplifier.

Abstract: A core cap or top plate for use with loudspeakers that includes offset adhesive control grooves on the opposite faces of the disk-like core cap is disclosed. The grooves are offset from one another by a distance that makes the smallest dimension between any feature of the grooves about the same as the nominal thickness of the core cap. The core cap increases the magnetic flux capacity over prior art core cap designs, while maintaining features advantageous to error-proof the orientation of the core cap in the loudspeaker.

Abstract: A loudspeaker cone body made of plastic includes a base carrier material and a filler material. The base carrier material is selected to optimize overall flow, weight and stiffness. The filler material may be a nanomaterial that provides for adjustment of process and acoustic related characteristics in the loudspeaker cone body that become relevant when the loudspeaker cone body is operated in a loudspeaker. Acoustic related characteristics that may be adjusted include a stiffness to weight ratio and an acoustic damping of the loudspeaker cone body. A predetermined weight percent of the filler material may be combined with the base carrier material to obtain repeatable desired acoustic related characteristics. The acoustic related characteristics may be adjusted by changing the predetermined weight percent of the filler material.

Abstract: An electro-dynamic loudspeaker is provided with dampening arrangements that contribute to improved acoustical properties for the electro-dynamic planar loudspeaker. The dampening arrangements include providing a frame having a curved sidewall surface for reducing standing waves. Another design provides for a ferrofluid being disposed between the diaphragm and magnets of the electro-dynamic loudspeaker in order to dampen the resonance frequency of the device. In addition, a diaphragm of an electro-dynamic loudspeaker is provided with a short turn of conductor disposed along a fringe zone at an edge of the diaphragm in order to electro-dynamically dampen the edge resonance of the film.

Abstract: An electro-dynamic loudspeaker is provided with dampening arrangements that contribute to improved acoustical properties for the electro-dynamic planar loudspeaker. The dampening arrangements include providing a frame having a curved sidewall surface for reducing standing waves. Another design provides for a ferrofluid being disposed between the diaphragm and magnets of the electro-dynamic loudspeaker in order to dampen the resonance frequency of the device. In addition, a diaphragm of an electro-dynamic loudspeaker is provided with a short turn of conductor disposed along a fringe zone at an edge of the diaphragm in order to electro-dynamically dampen the edge resonance of the film.

Abstract: A compound pinion for an epicyclic gearbox has a tubular shaft, two pinion portions freely rotatable on this shaft and a torsion bar interconnecting the pinion portions. In the gearbox the torsion bars of the several pinions can "wind up" to ensure that the load is evenly shared by the pinions.