Abstract: This invention relates generally to imidazo[1,2-a]pyridine-based modulators of Liver X receptors (LXRs) having formula (I) and related methods: wherein R2 is C6-C10 aryl or heteroaryl including 5-10 atoms, each of which is: (i) substituted with 1 R7, and (ii) optionally substituted with from 1-5 Re; and R1, R3, R4, R5, R6, R7, and Re are defined herein.

Abstract: This invention provides anti-inflammatory agents of formula I, having the structure wherein A and R1-R10 are as defined in the specification, or a N-oxide thereof or a pharmaceutically acceptable salt thereof or a prodrug thereof.

Abstract: The present invention relates generally to phenanthridine carbonyl compositions such as substituted phenanthridine carbonyl phenols of Formula 1: wherein R1 to R15 are as defined in the specification, or pharmaceutically acceptable salts thereof; and methods of using them.

Abstract: This invention provides compounds of Formula I having the structure wherein A, B, Z, R and R1 are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.

Abstract: An on demand, non-contact sensor controlled flush valve actuation system includes a flush valve between a water supply and a plumbing fixture. An actuator for the flush valve includes a moveable piston in fluid communication with a control water inlet, with a control water conduit carrying water from the flush valve through a solenoid operated control valve to the actuator assembly. A radiation sensing/detecting unit generates a first control signal in response to the return reflection of infrared radiation. A timer receives the first control signal and, in response thereto, generates a second control signal of a predetermined duration which activates the solenoid. When the solenoid is activated, a portion of the pressurized supply water flows into the actuator assembly and against a piston therein, with the piston moving to operate a trip mechanism for the flush valve.