Abstract: The invention provides compounds of the Formula (I) or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R1, R2, R4, Ra, and the subscripts m, p, and q are as described herein. The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate (“cGMP”), and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose.

Abstract: A lateral tilting system comprising one or more crossbeams that are each pivotably supported by a respective base member for pivotable motion about a common longitudinal axis. A drive mechanism is operably connected to a drive shaft to mechanically drive pivotable motion of the crossbeams about the axis, and resulting lateral tilt of an associated treadmill deck. A control system may be included to receive a user's input for controlling an oscillation rate or other parameter of the lateral tilting, and optionally longitudinal incline of the treadmill deck. A novel treadmill including a lateral tilting system and a lateral tilting accessory for conventional exercise equipment are provided also.

Abstract: A lateral tilting system comprising one or more crossbeams that are each pivotably supported by a respective base member for pivotable motion about a common longitudinal axis. A drive mechanism is operably connected to a drive shaft to mechanically drive pivotable motion of the crossbeams about the axis, and resulting lateral tilt of an associated treadmill deck. A control system may be included to receive a user's input for controlling an oscillation rate or other parameter of the lateral tilting, and optionally longitudinal incline of the treadmill deck. A novel treadmill including a lateral tilting system and a lateral tilting accessory for conventional exercise equipment are provided also.

Abstract: The invention provides compounds of the Formula (I) or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R1, R2, R4, Ra, and the subscripts m, p, and q are as described herein. The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate (“cGMP”), and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose.

Abstract: The invention provides compounds of the Formula (I) or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R1, R2, R4, Ra, and the subscripts m, p, and q are as described herein. The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate (“cGMP”), and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose.

Abstract: A carrying device for large panels, such as drywall, plywood and the like. The carrying device includes a rigid one-piece panel receiving bracket with a dual flexible strap and adjustable handle extending therefrom. The panel is received on a platform portion of the bracket which has multiple impact surfaces for positioning, engaging and releasing the bracket from the panel so positioned thereon and a panel positioning strap handle attachment extending therefrom.

Abstract: A carrying device for large panels, such as drywall, plywood and the like. The carrying device includes a rigid one-piece panel receiving bracket with a dual flexible strap and adjustable handle extending therefrom. The panel is received on a platform portion of the bracket which has multiple impact surfaces for positioning, engaging and releasing the bracket from the panel so positioned thereon and a panel positioning strap handle attachment extending therefrom.

Abstract: A lateral tilting system comprising one or more crossbeams that are each pivotably supported by a respective base member for pivotable motion about a common longitudinal axis. A drive mechanism is operably connected to a drive shaft to mechanically drive pivotable motion of the crossbeams about the axis, and resulting lateral tilt of an associated treadmill deck. A control system may be included to receive a user's input for controlling an oscillation rate or other parameter of the lateral tilting, and optionally longitudinal incline of the treadmill deck. A novel treadmill including a lateral tilting system and a lateral tilting accessory for conventional exercise equipment are provided also.

Abstract: The invention provides compounds of the Formula (I) or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R1, R2, R4, Ra, and the subscripts m, p, and q are as described herein. The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate (“cGMP”), and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose.

Abstract: The invention relates to compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, which are soluble guanylate cyclase activators. The compounds are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.

Abstract: The invention relates to compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, which are soluble guanylate cyclase activators. The compounds are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.

Abstract: A method and apparatus for oral hygiene, in particular having an oral hygiene device similar to a WATER PIK® brand device which has a pump with an inlet port and an outlet nozzle. A reservoir is placed in a sink above a drain and below a faucet and water from the faucet is adjusted for temperature and flows into the reservoir and over and into the drain of the sink. A conduit is provided between the inlet of the pump and the outlet of the reservoir so that, in use, a person can first adjust the temperature of the water in the reservoir and then turn on the pump and use the oral hygiene device as with any other oral hygiene apparatus while either allowing the water to continue to flow from the faucet at the desired temperature; or, if desired, to stop the flow and put medication into the container before use so that the water and medication solution is used rather than just water.

Abstract: A chilled probe for quickly and conveniently cooling a liquid is positioned to permit a user to insert the probe into the liquid to be cooled. Feedback, in the form of an indication of a representative liquid temperature, is also provided to increase the value of the method and apparatus. Individual sleeves are conveniently provided on a roll to keep the chilled probe from coming into direct contact with the liquid, thereby avoiding contamination between liquid samples being cooled.

Abstract: A chilled probe for quickly and conveniently cooling a liquid is positioned to permit a user to insert the probe into the liquid to be cooled. Feedback, in the form of an indication of a representative liquid temperature, is also provided to increase the value of the method and apparatus. Individual sleeves are conveniently provided on a roll to keep the chilled probe from coming into direct contact with the liquid, thereby avoiding contamination between liquid samples being cooled.

Abstract: A device for holding in place a flexible bag, such as a plastic garbage bag, that is attached to the outside wall of a trash can, or molded into the top portion of a trash can. The invention is a resilient one piece clamp formed of an elastomeric material. The clamp has complementary projections and indentations respectively on mating surfaces of the first and second portions of the clamp that hold the bag in place. The present invention can have two embodiments: one being a clamp attached to adhesive material that attaches to the outside wall of a trash can, the other embodiment is where the entire garbage can and clamp is of one piece construction.

Abstract: A method and apparatus for oral hygiene, in particular having an oral hygiene device similar to a WATER PIK® brand device which has a pump with an inlet port and an outlet nozzle. A reservoir is placed in a sink above a drain and below a faucet and water from the faucet is adjusted for temperature and flows into the reservoir and over and into the drain of the sink. A conduit is provided between the inlet of the pump and the outlet of the reservoir so that, in use, a person can first adjust the temperature of the water in the reservoir and then turn on the pump and use the oral hygiene device as with any other oral hygiene apparatus while either allowing the water to continue to flow from the faucet at the desired temperature; or, if desired, to stop the flow and put medication into the container before use so that the water and medication solution is used rather than just water.

Abstract: Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

Abstract: An animal accommodation station includes a base positionable upon a selected surface and supporting a shaft in an upright position. A canopy is carried at the upper end of the shaft. At an intermediate location, a cantilevered beam extends radially from the shaft. Food receptacles are detachably carried by the beam. A collar, rotatably coupled with the shaft intermediate the base and the beam, supports a radially extending arm having a free end to which is attached an animal leash.

Abstract: The present invention relates to spirocyclic ureas, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.

Abstract: A door stop and holder apparatus (10) including a generally wedge shaped stop member (20) connected by a tether member (50) to a hollow receptacle member (40) the rear face (41) of which is affixed to a door (100) and the front face (42) of which is provided with at least one receptacle element (45) dimensioned to receive a portion of a bumper member (60) that projects outwardly from the front face (42) of the holster member (40).