Abstract: HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

Abstract: An antenna assembly has four RF elements, each having a first configured for a first polarization, and a second port configured for a second polarization. An RF network connects to the eight RF element ports with four output ports providing two sets of orthogonal polarizations. The four outputs can be used for 4×4 MIMO. One embodiment uses the arrangement to feed an RF lens antenna.

Abstract: This disclosure describes a pickup location determination system that determines a pickup location for a received transportation request by filtering out door points based on various factors and by utilizing a pickup location model to select a pickup location from the filtered door points. For example, the disclosed systems generate door points relative to intersection points within a request radius of a request location associated with a received transportation request. The disclosed systems generate potential pickup locations by filtering out door points that are impractical and/or inefficient based on proximity to other door points, locations relative to venues, locations relative to side streets, and/or locations between parallel road segments (e.g., medians). The disclosed systems further utilize a pickup location model to select a pickup location from the potential pickup locations.

Abstract: A biodegradable duck nesting system includes a first member having a hollow interior, and a second member disposed in the first member. The system includes a biodegradable hollow enclosure having an opening sized to allow a duck to enter and/or exit the enclosure. The system also includes a predator prevention member located below the enclosure for preventing predators from contacting the enclosure.

Abstract: A method for manufacturing an article, e.g. a nuclear pressure vessel. The method involves: a) charging at least one hopper with steel powder; b) supplying an oxide stripping medium to the steel powder in the at least one hopper; c) removing the oxide stripping medium and any oxide particles stripped from the steel powder from the at least one hopper; d) discharging the oxide stripped steel powder into a can that provides a mould for the article; and e) converting the steel powder to solid steel by hot isostatic pressing to form the article. Stripping the steel powder of oxides whilst the steel powder is in the at least one hopper optimises desirable material properties of the article and thereby quality and safety of the article.

Abstract: The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies and antigen binding fragments thereof may comprise specific VH, VL, and CDR polypeptides described herein. In some embodiments these antibodies and antigen binding fragments thereof bind to and/or compete for binding to specific epitope(s) on human PACAP. The invention is further directed to using these antagonistic anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, mast cell degranulation, and/or neuronal activation, are therapeutically beneficial, e.g., headache and migraine indications.

Abstract: A speaker system can include a first moving mass, such as a diaphragm, coupled to a fixed frame via a first non-rigid suspension and coupled to a voice coil. The speaker system can include a second moving mass, such as a motor assembly, coupled to the fixed frame. The speaker system can include a passive radiator coupled to the fixed frame via a second non-rigid suspension. The motor assembly and the diaphragm are configured to move in response to an audio drive signal, causing a pressure to be generated and a first force to be generated on the fixed frame. The fixed frame is configured so that the pressure is shunted to the first passive radiator that is configured to generate a second force in response to the shunted pressure causing a second force on the fixed frame that cancels at least a portion of the first force.

Abstract: A system for monitoring a joint of a subject is described. The system includes at least one sensor configured to be coupled near the joint of the subject, the at least one sensor configured to sense one or more measurements of the joint. The system also includes a computing device comprising a digital processing device configured to receive the one or more measurements, determine one or more joint parameters based on the one or more measurements, generate a user interface for display, the user interface including a graphical representation of the one or more joint parameters. The digital processing device is also configured to compare the one or more joint parameters to a predetermined threshold and generate an icon for display within the user interface. The icon being generated in response to one of the one or more joint parameters exceeding the predetermined threshold.

Abstract: An adjustable animal washing system includes an enclosure structure forming an interior volume. An animal is to be located at least partially in the interior volume. Spray devices are disposed in the interior volume. At least a portion of the enclosure structure is adjustable to change one or more dimensions of the interior volume based on size of the animal or one or more of the plurality of spray devices are adjustable to wash the animal based on the size of the animal.

Abstract: This disclosure describes a pickup location determination system that determines a pickup location for a received transportation request by filtering out door points based on various factors and by utilizing a pickup location model to select a pickup location from the filtered door points. For example, the disclosed systems generate door points relative to intersection points within a request radius of a request location associated with a received transportation request. The disclosed systems generate potential pickup locations by filtering out door points that are impractical and/or inefficient based on proximity to other door points, locations relative to venues, locations relative to side streets, and/or locations between parallel road segments (e.g., medians). The disclosed systems further utilize a pickup location model to select a pickup location from the potential pickup locations.

Abstract: A communication system includes an array of RF elements that transit and/or receive signals through a lens, and a power divider is configured to provide unequal amplitude and/or phase to at least some of the RF elements. In transmit mode, the shape and direction of the resulting beam is controlled in part by the shape of the array, the relative power distributed to the different RF elements, the operating frequency, the shape of the lens, the position of the lens with respect to the array, and the distance of the lens from the array.

Abstract: An expandable spinal implant having a first portion and a second portion is provided. The expandable implant includes a first moveable portion and a second moveable portion attached to the first portion. The first moveable portion and the second moveable portion are moveable independently of one another. The movement of the first moveable portion and the second moveable portion facilitate independent expansion of a trailing end portion and a leading end portion of the expandable implant.

Abstract: A biodegradable duck nesting system is disclosed. The system includes a first member having a hollow interior, and a second member disposed in the first member. The system includes a biodegradable hollow enclosure having an opening sized to allow a duck to enter and/or exit the enclosure. The system also includes a predator prevention member located below the enclosure for preventing predators from contacting the enclosure.

Abstract: A system includes an authenticated encryption layer comprising logic configured to encrypt data received at the authenticated encryption layer from an authorized application at a source node. The data is encrypted using a first key to obtain first encrypted data. The logic is configured to encrypt the first encrypted data using a second key to obtain second encrypted data and generate a watermark for the first encrypted data and/or a watermark for the second encrypted data. The logic is configured to generate a watermark token for the first encrypted data and/or a watermark token for the second encrypted data.

Abstract: A scrubbing solution for removing contaminants, including particularly hydrogen sulfide, from a fluid. The scrubbing solution includes at least one scrubbing reagent which has a primary or secondary amine and an acid, which may be phosphoric acid. The fluid being scrubbed is passed through the scrubbing solution. The contaminants react with the scrubbing reagent securing them in the scrubbing solution. The fluid being scrubbed and the scrubbing solution are then separated. The scrubbing solution is heated and, if the scrubbing solution is under pressure, the pressure is reduced. The acid facilitates thorough removal of the contaminants, and especially the hydrogen sulfide, from the scrubbing solution. The scrubbing solution is then ready for reuse. Because the scrubbing solution is rendered substantially free of hydrogen sulfides, it can absorb other sulfide contaminants that might not otherwise be absorbed.

Abstract: A computer-implemented method includes receiving, by a storage system, encrypted data and a set of key identifiers. Each key identifier is associated with information specifying a storage location for which the key identifier is authorized. The method also includes storing, by the storage system, the encrypted data in at least one storage location and receiving, by the storage system, at least one key identifier of the set of key identifiers with a data access request. The method includes determining, by the storage system, whether the data access request is authorized for the at least one key identifier.

Abstract: A multi-beam communication system uses an array of antenna assemblies, and RF elements, to provide two or more sets of multiple beams, where each individual set of beams can be considered a beam state. An antenna assembly has a first set of RF elements oriented to produce a first beam state, and a second set of RF elements oriented to produce a second beam state. Each set of RF elements comprise a set of output sectors, where a controller is configured to selectively activate a beam state.

Abstract: A scrubbing solution for removing contaminants, including particularly hydrogen sulfide, from a fluid. The scrubbing solution includes at least one scrubbing reagent which has a primary or secondary amine and an acid, which may be phosphoric acid. The fluid being scrubbed is passed through the scrubbing solution. The contaminants react with the scrubbing reagent securing them in the scrubbing solution. The fluid being scrubbed and the scrubbing solution are then separated. The scrubbing solution is heated and, if the scrubbing solution is under pressure, the pressure is reduced. The acid facilitates thorough removal of the contaminants, and especially the hydrogen sulfide, from the scrubbing solution. The scrubbing solution is then ready for reuse. Because the scrubbing solution is rendered substantially free of hydrogen sulfides, it can absorb other sulfide contaminants that might not otherwise be absorbed.

Abstract: A method, system, and computer program product for key in lockbox encrypted data deduplication are provided. The method collects a set of deduplication information by a host in communication with a storage system via a communications network. A fingerprint is generated for a data chunk to be stored on a storage system. The method encrypts the data chunk using a first encryption key to generate an encrypted data chunk. The fingerprint is encrypted with a second encryption key to generate an encrypted fingerprint. The method encrypts the first encryption key with a third encryption key to generate a first encrypted key. The method encrypts the first encryption key with a fourth encryption key to generate a second encryption key. A data package is generated for transmission to the storage system. The method transmits the data package to the storage system.