Abstract: Disclosed are compounds for inhibiting lipoamide dehydrogenase (Lpd), and methods of treating tuberculosis.

Abstract: A method of forming an erosion shield for a turbine blade includes depositing a layer of filler material defining an upper surface. The method also includes depositing a layer of erosion-resistant material across the upper surface of the layer of filler material. An interface is defined between the layer of filler material and the layer of erosion-resistant material and has a shape of the upper surface. The method also includes machining the layer of filler material to produce the erosion shield. The erosion shield has the layer of erosion-resistant material, the machined layer of filler material, and the interface defined therebetween. An inner surface of the erosion shield is defined by the machined layer of filler material that is sized and shaped for attaching to a leading edge of the turbine blade. Each of the interface and the inner surface extend a length of the erosion shield.

Abstract: A method of manufacturing an erosion-shielded turbine blade includes providing a turbine blade for use with a rotary machine. The turbine blade includes an airfoil extending between a root and a tip. The airfoil includes a pressure side and an opposite suction side, and each of the pressure and suction sides extends between a leading edge and a trailing edge. The method also includes printing a green body part by an additive manufacturing process by selectively depositing a binder solution across a particulate erosion-resistant material, and sintering the green body part to produce a post-sintering erosion shield that includes densified erosion-resistant material. The method also includes coupling the erosion shield to the leading edge of the turbine blade.

Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

Abstract: A class of pyrimidoheterocyclic compounds, and specifically disclosed is a compound represented by formula (III) or a pharmaceutically acceptable salt thereof.

Abstract: Techniques are provided for single sided beam management in a millimeter wave (mmW) communication system for use in bistatic radio frequency (RF) sensing. An example method of tracking targets with bistatic radio frequency sensing includes receiving a scanning reference signal, generating a scanning signal report indicating one or more target groups associated with the scanning reference signal, transmitting the scanning signal report, receiving tracking signal configuration information indicating a tracking reference signal associated with the one or more target groups, receiving the tracking reference signal identified in the tracking signal configuration information, and tracking the one or more target groups associated with the tracking reference signal.

Abstract: Disclosed is a polymeric blend and a method of making and using the same. The polymeric blend includes 75 wt. % to 99 wt. % of a first polypropylene composition comprising polypropylene and having a melt flow rate (MFR) of A g/10 min as measured by ASTM D1238 (230° C./2.16 kg), wherein the first polypropylene composition has been previously extruded prior to forming the blend, and 1 wt. % to 25 wt. % of a second polypropylene composition comprising polypropylene and an organic peroxide and having a MFR of B g/10 min as measured by ASTM D1238 (230° C./2.16 kg), wherein the second polypropylene composition has been previously extruded prior to forming the blend, wherein the polymeric blend has a MFR of C g/10 min as measured by ASTM D1238 (230° C./2.16 kg), and wherein C is greater than A.

Abstract: This disclosure relates to the cross carrier scheduling of sidelink carrier aggregation, and includes a method and apparatus for determining a component carrier (CC) index for at least one of a first sidelink transmission with a second UE and a Uu transmission with a network entity, the CC index indicating one or more CCs among which at least one of the first sidelink transmission and the Uu transmission occur; and communicating at least one of the first sidelink transmission to the second UE and the Uu transmission to the network entity based on the CC index.

Abstract: The present invention provides for a method for producing a 4-vinylphenol (4VP) and/or 4-vinylguaiacol (4VG), the method comprising: (a) providing a host cell capable of expressing a polypeptide having a phenolic acid decarboxylase (PAD) enzymatic activity wherein the polypeptide is capable of converting p-coumaric (CA) and/or ferulic acid (FA) into 4-vinylphenol (4VP) and/or 4-vinylguaiacol (4VG), respectively; and (b) culturing the host cell in a culture medium to express the polypeptide such that the polypeptide converts CA and/or FA into 4VP and/or 4VG, respectively; wherein the culture medium comprises an organic overlay or phase.

Abstract: A modified Kalman filter may include one or more neural networks to augment or replace components of the Kalman filter in such a way that the human interpretability of the filter's inner functions is preserved. The neural networks may include a neural network to account for bias in measurement data, a neural network to account for unknown controls in predicting a state of an object, a neural network ensemble that is trained differently based on different sensor data, a neural network for determining the Kalman gain, and/or a set of Kalman filters including various neural networks that determine independent estimated states, which may be fused using Bayesian fusion to determine a final estimated state.

Abstract: Described herein are compositions and methods for treating cancer and autoimmune diseases.

Abstract: A control circuit receives personally identifiable information that corresponds to a particular entity. The control circuit uses that personally identifiable information to access a block chain ledger that serves as an identity block chain ledger. The control circuit then receives a synthetic identifier from the block chain ledger. This synthetic identifier correlates to the aforementioned personally identifiable information and also correlates to other data that corresponds to the particular entity and which other data is stored in a data storage element other than the block chain ledger.

Abstract: A coordinating network element manages a protocol that prohibits the coordinating network element from substantively accessing data content that, at least in part, underlies received protocol-compliant requests. By one approach, these teachings provide for preventing substantive access to data information that is included within the protocol-compliant request in tokenized form, wherein the tokens are generated using secrets, at least one of which is unavailable to the coordinating network element.

Abstract: Embodiments of the disclosure relate generally to formulations, methods, kits, and dosage forms for improved stability comprising at least two active ingredients, AMD3100, or similar stem cell mobilizer, and Tacrolimus, or FK506 derivative or analog, and one or more excipients. The formulations may be administered as a single dose subcutaneous injection. The formulations may be useful in treating various diseases, disorders or injuries.

Abstract: A data system and processes that generate structural characteristics and analytics such as various elevations and heights of a structure. Information produced in on-demand fashion and can be certified. It combines human intelligence with machine intelligence to achieve optimal results. Information produced by the system are significant for many purposes, including Flood Risk Assessment, Flood Insurance Rating, and Flood Impacting Threshold (FIT) determination. The system further generates various derivatives such as Flood Impacting Threshold Score (FITS), precise Flood Risk Ratings (e.g. PrecisionRating,) building conditions and valuation. The system generates such information on-demand by computer vision, artificial intelligence, sensors, image analysis, statistical analysis, and mathematical analysis through a Graphic User Interface (GUI) or machine-to-machine, and Application Programming Interface (API.

Abstract: Described herein are compositions and methods for treating cancer and autoimmune diseases.

Abstract: A battery material includes: a conductive substrate; and a silicon material layer disposed on at least one side of the conductive substrate and including silicon fibers, at least some of which aggregate to form silicon fibrous spheres. A preparation method for the battery material includes: (a) providing a conductive substrate; (b) providing a silicon-based material, followed by depositing on a surface of the silicon-based material a film comprising amorphous silicon or crystalline silicon to form a silicon source material; (c) placing the silicon source material of step (b) on at least a side of the conductive substrate of step (a), wherein the distance between the conductive substrate and the silicon source material is less than 100 mm; and (d) heating the conductive substrate and silicon source material thus arranged in step (c) to allow the silicon source material to release amorphous silicon or crystalline silicon.

Abstract: The present invention generates multiple models of water events based on various modeling processes input data. It can generate analytics of water events and integrating water models for displays. The present invention further produces derivatives, tools, and informational services for flood risk assessment; flood determination; and insurance rating. The present invention integrates and maintains all relevant inputs in one system for modeling water events at a given location in a timely fashion. The input datasets include water events' extent, flooded areas, floodplain, inundated areas and measurement of water condition. The datasets may include other data, such as, terrain elevation data, land use land cover data, soil conductivity, water gauge measurements and hydrologic regression equations for calculating flows.