Abstract: An aminopeptidase which is a component of GLUT4-containing vesicles in the natural state, and which cleaves insulin. The claimed protein has an apparent molecular weight of approximately 110 kD in its deglycosylated form and a predicted molecular weight of 117,239 Daltons. It includes the amino acid sequences Phe-Ala-Ala-Thr-Gln-Phe-Glu-Pro-Leu-Ala-Ala (SEQ ID NO: 1) and Ile-Leu-Gln-Asn-Gln-Ile-Gln-Gln-Gln-Thr-Arg-Thr-Asp-Glu-Gly-Xaa-Pro-Xaa-Me t (SEQ ID NO: 2, and reacts with antibodies produced against the peptide identified as (SEQ ID NO: 1). It is encoded by the cDNA of FIG. 20 (SEQ. ID NOs. 15 and 16) and is essentially the protein sequence therein described. Modulators of the activity of the aminopeptidase and a method for treating syndromes of insulin resistance, including diabetes, by administration of such a modulator are also claimed.

Abstract: Ultrasound imaging apparatus having an array of electro-acoustic transducer rings, means for exciting said transducer rings in sequence so as to cause them to transmit successive pulses of pressure waves along a path at intervals at least equal to the time of transit of the pressure waves to a maximum range and back to the array, dynamically controlled delays respectively coupled to each transducer ring that bring the electrical signals the transducers supply in response to pressure of waves of each pulse that are reflected along a given range into reasonable phase coherence, processing means coupled to the delays so as to provide a composite signal, and a summing memory coupled to receive the composite signal.

Abstract: A rigidifier for an inflatable boat of the type having a flexible floor and an inflatable tubular portion around the periphery of the floor forming a cockpit. The rigidifier comprises a floorboard member removable from and receivable in the cockpit to overlay the floor. The member is rigid in one direction to provide rigidity to the floor and collapsible in another direction so that it may be rolled up after being removed from the cockpit. The rigidifier further comprises a framework adapted for detachable connection to the floorboard member to provide rigidity to the floorboard member in another direction so that rigidity is provided to the floor of the boat in substantially all directions.