Patents by Inventor John T. Hunt
John T. Hunt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11911027Abstract: A surgical stapler, or fastening instrument, may generally comprise a layer, such as a tissue thickness compensator, for example, releasably attached to a fastener cartridge and/or anvil by a flowable attachment portion. The flowable attachment portion may be indefinitely flowable. The flowable attachment portion may be flowable from the time that layer is installed to the fastener cartridge to the time in which the layer is implanted to patient tissue. The flowable attachment portion may comprise a pressure sensitive adhesive. The flowable attachment portion may comprise an adhesive laminate comprising a base layer comprising the tissue thickness compensator and an adhesive layer on at least a portion of a surface of the base layer comprising the pressure sensitive adhesive. Articles of manufacture comprising flowable attachment portion and methods of making and using the flowable attachment portion are also described.Type: GrantFiled: November 15, 2019Date of Patent: February 27, 2024Assignee: Cilag GmbH InternationalInventors: Taylor W. Aronhalt, Michael J. Vendely, Lauren S. Weaner, Brandon J. Lloyd, Frederick E. Shelton, IV, Michael J. Miller, Michael T. Isaacs, Emily Ann Schellin, John V. Hunt, John E. Feds
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Patent number: 7244733Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.Type: GrantFiled: February 2, 2006Date of Patent: July 17, 2007Assignee: Bristol-Myers Squibb CompanyInventors: John T. Hunt, Rajeev S. Bhide, Robert Michael Borzilleri, Ligang Qian
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Patent number: 7173031Abstract: In general, the instant invention comprises compounds of Formulas I and II including pharmaceutically acceptable salts thereof. The compounds of the invention are useful as protein kinase inhibitors and therefore are useful for treating cancer and other protein kinase mediated diseases.Type: GrantFiled: June 24, 2005Date of Patent: February 6, 2007Assignee: Bristol-Myers Squibb CompanyInventors: Robert M. Borzilleri, Zhong Chen, John T. Hunt, Tram Huynh, Michael A. Poss, Gretchen M. Schroeder, Wayne Vaccaro, Tai W. Wong, Xiao-Tao Chen, Kyoung S. Kim
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Patent number: 7112675Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.Type: GrantFiled: July 27, 2005Date of Patent: September 26, 2006Assignee: Bristol-Myers Squibb CompanyInventors: John T. Hunt, Rajeev S. Bhide, Robert Michael Borzilleri, Ligang Qian
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Publication number: 20060004006Abstract: In general, the instant invention comprises compounds of Formulas I and II including pharmaceutically acceptable salts thereof. The compounds of the invention are useful as protein kinase inhibitors and therefore are useful for treating cancer and other protein kinase mediated diseases.Type: ApplicationFiled: June 24, 2005Publication date: January 5, 2006Inventors: Robert M. Borzilleri, Zhong Chen, John T. Hunt, Tram Huynh, Michael A. Poss, Gretchen M. Schroeder, Wayne Vaccaro, Tai W. Wong, Xiao-Tao Chen, Kyoung KIm
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Patent number: 6982265Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.Type: GrantFiled: May 18, 2000Date of Patent: January 3, 2006Assignee: Bristol Myers Squibb CompanyInventors: John T. Hunt, Rajeev S. Bhide, Robert Michael Borzilleri, Ligang Qian
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Patent number: 6900208Abstract: Disclosed are pyrrolopyridazine compounds of the formula, wherein the substituents are defined herein, methods of preparing such compounds, and their use for the treatment of proliferative, inflammatory, and other disorders.Type: GrantFiled: March 25, 2003Date of Patent: May 31, 2005Assignee: Bristol Myers Squibb CompanyInventors: Mark Salvati, Stephanie A. Barbosa, Zhong Chen, John T. Hunt
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Publication number: 20040063712Abstract: Disclosed are pyrrolopyridazine compounds, methods of preparing such compounds, and their use for the treatment of proliferative, inflammatory, and other disorders.Type: ApplicationFiled: March 25, 2003Publication date: April 1, 2004Inventors: Mark Salvati, Stephanie A. Barbosa, Zhong Chen, John T. Hunt
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Patent number: 6673824Abstract: Compounds of the formula inhibit the activity of endothelin. The symbols are defined as follows: R1, R2 and R3 are each independently (a) hydrogen, except that R1 is other than hydrogen; (b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z1, Z2 and Z3; (c) halo; (d) hydroxyl; (e) cyano; (f) nitro; (g) —C(O)H or —C(O)R6; (h) —CO2H or —CO2R6; (i) —SH, —S(O)nR6, —S(O)m—OH, —S(O)m—OR6, —O—S(O)m—R6, —O—S(O)mOH or —O—S(O)m—OR6; (j) —Z4—NR7R8; or (k) —Z4—N(R11)—Z5—NR9R10; and the remaining symbols are as defined in the specification.Type: GrantFiled: April 19, 2000Date of Patent: January 6, 2004Assignee: Bristol-Myers Squibb Co.Inventors: Natesan Murugesan, John T. Hunt, Philip D. Stein
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Patent number: 6602883Abstract: Disclosed are quinoline and benzazepine derivatives that inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogenic protein Ras. Thus, the compounds are useful as anti-cancer agents. The compounds are also useful in the treatment of diseases other than cancer.Type: GrantFiled: May 5, 2000Date of Patent: August 5, 2003Assignee: Bristol-Myers Squibb CompanyInventors: Rajeev S. Bhide, Charles Z. Ding, John T. Hunt, Soong-Hoon Kim, Katerina Leftheris
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Patent number: 6521759Abstract: The present invention describes compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, m and n are as defined in the specification. The compounds of formula I are protein kinase inhibitors and are useful in the treatment of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of Alzheimer's disease, chemotherapy-induced alopecia, and cardiovascular disease.Type: GrantFiled: April 20, 2001Date of Patent: February 18, 2003Assignee: Bristol-Myers Squibb CompanyInventors: Kyoung S. Kim, S. David Kimball, Zhen-wei Cai, David B. Rawlins, Raj N. Misra, Michael A. Poss, Kevin R. Webster, John T. Hunt, Wen-Ching Han
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Patent number: 6458783Abstract: Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, is effected by compounds of the formulas their enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs and solvates thereof.Type: GrantFiled: April 21, 2000Date of Patent: October 1, 2002Assignee: Bristol-Myers Squibb CompanyInventors: Charles Z. Ding, John T. Hunt, Katerina Leftheris, Rajeev S. Bhide
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Publication number: 20020137778Abstract: The present invention describes compounds of formula I: 1Type: ApplicationFiled: April 20, 2001Publication date: September 26, 2002Inventors: Kyoung S. Kim, S. David Kimball, Zhen-Wei Cai, David B. Rawlins, Raj N. Misra, Michael A. Poss, Kevin R. Webster, John T. Hunt, Wen-Ching Han
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Patent number: 6455523Abstract: Inhibition of farnesyl transferase, which is an enzyme involved in ras ocogene expression, is effected by compounds of the formulas their enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs and solvates thereof inhibit farnesyl protein transferase which is an enzyme involved in ras oncogene expression.Type: GrantFiled: August 13, 1999Date of Patent: September 24, 2002Assignee: Bristol-Myers Squibb CompanyInventors: Charles Z. Ding, Soong-Hoon Kim, John T. Hunt, Toomas Mitt, Rajeev Bhide, Katerina Leftheris
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Patent number: 6387926Abstract: Disclosed are quinoline and benzazepine derivatives that inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogenic protein Ras. Thus, the compounds are useful as anti-cancer agents. The compounds are also useful in the treatment of diseases other than cancer.Type: GrantFiled: May 29, 1998Date of Patent: May 14, 2002Assignee: Bristol-Myers Squibb CompanyInventors: Rajeev S. Bhide, Charles Z. Ding, John T. Hunt, Soong-Hoon Kim, Katerina Leftheris
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Patent number: 6262096Abstract: Compounds of the formula and pharmaceutically acceptable salts thereof. R1 and R2 are independently hydrogen, fluorine or alkyl; R3 is aryl or heteroaryl R4 is alkyl, cycloalkyl, aryl, cycloalkylalkyl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl; m is an integer of 0 to 2; and n is an integer of 1 to 3. The compounds of formula I are protein kinase inhibitors and are useful in the treatment and prevention of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of neurodegenerative diseases such as Alzheimer's disease, cardiovascular diseases, viral diseases and fungal diseases.Type: GrantFiled: December 15, 1999Date of Patent: July 17, 2001Assignee: Bristol-Myers Squibb CompanyInventors: Kyoung S. Kim, S. David Kimball, Zhen-wei Cai, David B. Rawlins, Raj N. Misra, Michael A. Poss, Kevin R. Webster, John T. Hunt, Wen-Ching Han
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Patent number: 6156746Abstract: Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, is effected by compounds of the formula ##STR1## and their enantiomers, diastereomers, and their pharmaceutically acceptable salts, including prodrugs and solvates thereof.The compounds of formula I are useful in the treatment of a variety of cancers. In addition, the formula I compounds may also be useful in the treatment of diseases other than cancer.Type: GrantFiled: July 15, 1999Date of Patent: December 5, 2000Assignee: Bristol-Myers Squibb CompanyInventors: Katerina Leftheris, John T. Hunt, Charles Z. Ding
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Patent number: 6107320Abstract: Compounds of the formula ##STR1## inhibit the activity of endothelin. The symbols are defined as follows: R.sup.1, R.sup.2 and R.sup.3 are each independently(a) hydrogen, except that R.sup.1 is other than hydrogen;(b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z.sup.1, Z.sup.2 and Z.sup.3 ;(c) halo;(d) hydroxyl;(e) cyano;(f) nitro;(g) --C(O)H or --C(O)R.sup.6 ;(h) --CO.sub.2 H or --CO.sub.2 R.sup.6 ;(i) --SH, --S(O).sub.n R.sup.6, --S(O).sub.m --OH, --S(O).sub.m --OR.sup.6, --O--S(O).sub.m --R.sup.6, --O--S(O).sub.m OH or --O--S(O).sub.m --OR.sup.6 ;(j) --Z.sup.4 --NR.sup.7 R.sup.8 ; or(k) --Z.sup.4 --N(R.sup.11)--Z.sup.5 --NR.sup.9 R.sup.10 ;and the remaining symbols are as defined in the specification.Type: GrantFiled: January 11, 1996Date of Patent: August 22, 2000Assignee: Bristol-Myers Squibb Co.Inventors: Natesan Murugesan, John T. Hunt
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Patent number: 6040321Abstract: Compounds of the formula ##STR1## and pharmaceuticaly acceptable salts thereof. As used in formula I, and throughout the specification, the symbols have the following meanings:R.sub.1 and R.sub.2 are independently hydrogen, fluorine or alkyl;R.sub.3 is aryl or heteroarylR.sub.4 is hydrogen, alkyl, cycloalkyl, aryl, cycloalkylalkyl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl; orCO-alkyl,CONH-alkyl,COO-alkyl,SO.sub.2 -alkyl,C(NCN)NH-alkyl,C(NNO.sub.2)NH-alkyl,C(NH)NH-alkyl,C(NH)NHCO-alkyl,C(NOR.sub.6)NH-alkyl,R.sub.5 is hydrogen or alkyl;R.sub.6 is hydrogen, alkyl, cycloalkyl, aryl, cycloalkylakyl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl;m is an integer of 0 to 2; andn is an integer of 1 to 3.The compounds of formula I are protein kinase inhibitors and are useful in the treatment and prevention of proliferative diseases, for example, cancer, inflammation and arthritis.Type: GrantFiled: October 21, 1998Date of Patent: March 21, 2000Assignee: Bristol-Myers Squibb CompanyInventors: Kyoung S. Kim, S. David Kimball, Zhen-wei Cai, David B. Rawlins, Raj N. Misra, Michael A. Poss, Kevin R. Webster, John T. Hunt, Wen-Ching Han
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Patent number: 6011029Abstract: The present invention comprises benzodiazepine compounds having farnesyl transferase inhibitory activity.Type: GrantFiled: February 20, 1997Date of Patent: January 4, 2000Assignee: Bristol-Myers Squibb CompanyInventors: Charles Z. Ding, Soong-Hoon Kim, John T. Hunt, Toomas Mitt, Rajeev Bhide, Katerina Leftheris