Abstract: In certain aspects, the disclosure relates to anti-idiotype antibodies and antigen-binding portions thereof that specifically bind a KL2B413 containing protein, e.g., an antibody or antigen-binding portions thereof. In some aspects, the anti-idiotype antibodies and antigen-binding portions of the present disclosure can be used in methods to detect and quantify cells expressing chimeric antigen receptors that include KL2B413.

Abstract: The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a human Kallikrein-2 (hK2), and immunoresponsive cells comprising such CARs, for the treatment of cancer.

Abstract: In certain aspects, the disclosure relates to anti-idiotype antibodies and antigen-binding portions thereof that specifically bind a GP5B83 containing protein, e.g., an antibody or antigen-binding portions thereof. In some aspects, the anti-idiotype antibodies and antigen-binding portions of the present disclosure can be used in methods to detect and quantify cells expressing chimeric antigen receptors that include GP5B83.

Abstract: In certain aspects, the disclosure relates to anti-idiotype antibodies and antigen-binding portions thereof that specifically bind a KL2B413 containing protein, e.g., an antibody or antigen-binding portions thereof. In some aspects, the anti-idiotype antibodies and antigen-binding portions of the present disclosure can be used in methods to detect and quantify cells expressing chimeric antigen receptors that include KL2B413.

Abstract: The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a human Kallikrein-2 (hK2), and immunoresponsive cells comprising such CARs, for the treatment of cancer.

Abstract: In certain aspects, the disclosure relates to anti-idiotype antibodies and antigen-binding portions thereof that specifically bind a GP5B83 containing protein, e.g., an antibody or antigen-binding portions thereof. In some aspects, the anti-idiotype antibodies and antigen-binding portions of the present disclosure can be used in methods to detect and quantify cells expressing chimeric antigen receptors that include GP5B83.

Abstract: Implementations described and claimed herein provide systems and methods for improving cash management system operation. In one implementation, a method for improving cash management system operation includes detecting an intervention event in connection with user activity of a user involving a cash management system. The method determines whether the intervention event meets an intervention threshold. A customized intervention particular to the intervention event and a the user is generated when the intervention event meets the intervention threshold. The customized intervention is output for presentation to the user. The customized intervention improves the user activity involving the cash management system.

Abstract: The present invention provides for managing applications associated with an installation. In an embodiment, instructions are received that enable an installation management system to determine how to manage an application associated with the installation. The instructions conform to an application modeling language that specifies a definition that can be used to write instructions for more than one application without requiring knowledge of the installation management system. The instructions are analyzed to enable the installation management system to determine how to manage the application.

Abstract: An apparatus for grinding molded friction products comprises a rotary indexing table with a substantially horizontal indexing table. The table surface indexes from one indexing position to another. Tool fixtures support friction product parts to be ground on a friction surface thereof. The tool fixtures are disposed on the rotary indexing table at the indexing positions. A grind stone is disposed above the indexing table surface for grinding the friction product part supported in the tool fixture at one of the indexing positions. The grind stone rotates about a grind axis which is substantially parallel to said central axis of said indexing grind table, but can be tilted by a small angle so as to provide a skim cut grind to the product. The method provides for performing operations at all indexing positions simultaneously.

Abstract: A thin-film disc fabrication method and structure contemplates a sputtered undercoat. An aluminum base is subjected to a fine polishing step, and a relatively thin undercoat is deposited by sputtering. The preferred undercoat is a 0.3-3 micron layer of nickel-vanadium alloy (on the order of 7% vanadium). The preferred recording layer is a sputtered composite structure comprising a layer of chromium and an overlying layer of a cobalt-chromium alloy. Modulation effects can be substantially eliminated by heating the aluminum base prior to sputtering the nickel-vanadium undercoat, and by oxidizing the undercoat prior to deposition of the overlying layers.