Abstract: A toothbrush assembly comprising an elongated hollow handle defining a chamber for a cartridge filled with toothpaste, a brush head assembly detachably mounted at one end of the handle having a series of flexible valves, an actuator assembly mounted at the opposite open end of the handle including a piston engagable with a rear seal of the cartridge and actuatable axially in the cartridge to displace toothpaste through a channel in the brush head assembly and through the series of valves in the brush head which open to permit release of toothpaste and close automatically to a closed position when piston advance is stopped.