Patents by Inventor John T. Mulligan
John T. Mulligan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7977312Abstract: A novel class or family of TGF-? binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.Type: GrantFiled: October 31, 2007Date of Patent: July 12, 2011Assignee: Darwin Discovery LimitedInventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David J. Winkler
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Publication number: 20110150866Abstract: A novel class or family of TGF-? binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.Type: ApplicationFiled: October 31, 2007Publication date: June 23, 2011Applicant: Darwin Discovery LimitedInventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
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Patent number: 7758858Abstract: Compositions and methods for increasing bone density using antibodies directed to a novel class or family of TGF-? binding proteins are provided. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases associated with a loss of bone density, for example osteoporosis.Type: GrantFiled: February 27, 2004Date of Patent: July 20, 2010Assignee: Darwin Discovery Ltd.Inventors: Mary E Brunkow, David J Galas, Brian Kovacevich, John T Mulligan, Bryan W Paeper, Jeffrey Van Ness, David G Winkler
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Patent number: 7642344Abstract: Methods and compounds, including compositions therefrom, are provided for determining the sequence of nucleic acid molecules. The methods permit the determination of multiple nucleic acid sequences simultaneously. The compounds are used as tags to generate tagged nucleic acid fragments which are complementary to a selected target nucleic acid molecule. Each tag is correlative with a particular nucleotide and, in a preferred embodiment, is detectable by mass spectrometry. Following separation of the tagged fragments by sequential length, the tags are cleaved from the tagged fragments. In a preferred embodiment, the tags are detected by mass spectrometry and the sequence of the nucleic acid molecule is determined therefrom. The individual steps of the methods can be used in automated format, e.g., by the incorporation into systems.Type: GrantFiled: June 21, 2007Date of Patent: January 5, 2010Assignee: Operon Biotechnologies, Inc.Inventors: Jeffrey Van Ness, John C Tabone, J Jeffry Howbert, John T Mulligan
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Patent number: 7572899Abstract: Nucleic acids relating to human TGF-? binding proteins are disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.Type: GrantFiled: March 7, 2002Date of Patent: August 11, 2009Assignee: UCB SAInventors: Mary E Brunkow, David J Galas, Brian Kovacevich, John T Mulligan, Bryan Paeper, Jeffrey Van Ness, David G Winkler
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Publication number: 20090137027Abstract: Polynucleotides having in excess of 1,000 nucleotides can be prepared using a solid phase synthesis technique. A feature of the technique is the use of a reusable solid support that contains covalently bound oligonucleotide. This covalently bound oligonucleotide is annealed to a bridge oligonucleotide, where the bridge is also annealed to a first oligonucleotide that forms a portion of the target polynucleotide. After the target polynucleotide is synthesized, it can be removed from the solid support under denaturing conditions, and the solid support re-used to prepare additional target polynucleotides. The yield of the target polynucleotide increases when shearing force is applied to the solid support that is linked to the growing oligonucleotide. This shearing force is thought to extend the growing end of the oligonucleotide away from contact with other oligonucleotide bound to the solid support and make that end more accessible to annealing with solution oligonucleotide.Type: ApplicationFiled: December 16, 2008Publication date: May 28, 2009Applicant: Blue Heron Biotechnology, Inc.Inventors: Hsing-Yeh Parker, John T. Mulligan
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Patent number: 7482119Abstract: Polynucleotides having in excess of 1,000 nucleotides can be prepared using a solid phase synthesis technique. A feature of the technique is the use of a reusable solid support that contains covalently bound oligonucleotide. This covalently bound oligonucleotide is annealed to a bridge oligonucleotide, where the bridge is also annealed to a first oligonucleotide that forms a portion of the target polynucleotide. After the target polynucleotide is synthesized, it can be removed from the solid support under denaturing conditions, and the solid support re-used to prepare additional target polynucleotides. The yield of the target polynucleotide increases when shearing force is applied to the solid support that is linked to the growing oligonucleotide. This shearing force is thought to extend the growing end of the oligonucleotide away from contact with other oligonucleotide bound to the solid support and make that end more accessible to annealing with solution oligonucleotide.Type: GrantFiled: October 13, 2004Date of Patent: January 27, 2009Assignee: Blue Heron Biotechnology, Inc.Inventors: Hsing-Yeh Parker, John T. Mulligan
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Publication number: 20080234219Abstract: A novel class or family of TGF-? binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.Type: ApplicationFiled: October 31, 2007Publication date: September 25, 2008Applicant: Darwin Discovery LimitedInventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
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Publication number: 20080182788Abstract: A novel class or family of TGF-? binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.Type: ApplicationFiled: October 31, 2007Publication date: July 31, 2008Applicant: Darwin Discovery LimitedInventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
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Patent number: 7285641Abstract: The present invention discloses antibodies that specifically bind to a WRN gene product or a portion thereof.Type: GrantFiled: February 25, 2003Date of Patent: October 23, 2007Inventors: Ying-Hui Fu, Chang-En Yu, Junko Oshima, John T Mulligan, Gerard D Schellenberg
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Patent number: 7247434Abstract: Methods and compounds, including compositions therefrom, are provided for determining the sequence of nucleic acid molecules. The methods permit the determination of multiple nucleic acid sequences simultaneously. The compounds are used as tags to generate tagged nucleic acid fragments which are complementary to a selected target nucleic acid molecule. Each tag is correlative with a particular nucleotide and, in a preferred embodiment, is detectable by mass spectrometry. Following separation of the tagged fragments by sequential length, the tags are cleaved from the tagged fragments. In a preferred embodiment, the tags are detected by mass spectrometry and the sequence of the nucleic acid molecule is determined therefrom. The individual steps of the methods can be used in automated format, e.g., by the incorporation into systems.Type: GrantFiled: July 16, 2003Date of Patent: July 24, 2007Assignee: Operon Biotechnologies, Inc.Inventors: Jeffrey Van Ness, John C Tabone, J Jeffry Howbert, John T Mulligan
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Patent number: 7192583Abstract: Antibodies to a novel family of TGF-? binding proteins are disclosed, for use in methods of altering bone density and bone mineralization, which methods are applicable to the treatment of diseases including osteopenia and osteoporosis.Type: GrantFiled: March 6, 2003Date of Patent: March 20, 2007Assignee: Darwin Discovery Ltd.Inventors: Mary E Brunkow, David J Galas, Brian Kovacevich, John T Mulligan, Bryan W Paeper, Jeffrey Van Ness, David G Winkler
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Patent number: 7164992Abstract: Methods and systems for automated polynucleotide synthesis design are provided. Example embodiments provide an Automated Polynucleotide Synthesis Design System (“APSDS”), which automatically generates a synthesis design for a designated target sequence specification. In one embodiment, the APSDS comprises a synthesis design engine, user interface support, a synthesis rules data repository, and a synthesis data repository. The APSDS automatically generates a synthesis design by receiving a target sequence(s) specification, generating a potential synthesis design, evaluating the potential design against synthesis rules, and when the evaluation indicates that the potential design is not successful according to the synthesis rules, adjusting the design to generate a new potential synthesis design and repeating the process of evaluating and adjusting until a potential synthesis design is found that satisfies the synthesis rules or until no solution is found.Type: GrantFiled: March 22, 2002Date of Patent: January 16, 2007Assignee: Blue Heron Biotechnology, Inc.Inventors: John T. Mulligan, John C. Tabone, R. Gregg Brickner
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Patent number: 7052846Abstract: Tags and linkers specifically designed for a wide variety of nucleic acid reactions are disclosed, which are suitable for a wide variety of nucleic acid reactions wherein separation of nucleic acid molecules based upon size is required.Type: GrantFiled: June 19, 2003Date of Patent: May 30, 2006Assignee: Operon Biotechnologies, Inc.Inventors: Jeffrey Van Ness, John C Tabone, J Jeffry Howbert, John T Mulligan
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Patent number: 6815212Abstract: Methods are provided for detecting the binding of a first member to a second member of a ligand pair, comprising the steps of (a) combining a set of first tagged members with a biological sample which may contain one or more second members, under conditions, and for a time sufficient to permit binding of a first member to a second member, wherein said tag is correlative with a particular first member and detectable by non-fluorescent spectrometry, or potentiometry, (b) separating bound first and second members from unbound members, (c) cleaving the tag from the tagged first member, and (d) detecting the tag by non-fluorescent spectrometry, or potentiometry, and therefrom detecting the binding of the first member to the second member.Type: GrantFiled: October 24, 2001Date of Patent: November 9, 2004Assignee: Qiagen Genomics, Inc.Inventors: Jeffrey Van Ness, John C. Tabone, J. Jeffry Howbert, John T. Mulligan
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Patent number: 6803453Abstract: Compositions and methods for increasing bone density using antibodies directed to a novel class or family of TGF-&bgr; binding proteins are provided. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases associated with a loss of bone density, for example osteoporosis.Type: GrantFiled: September 21, 2000Date of Patent: October 12, 2004Assignee: Darwin Discovery Ltd.Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
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Publication number: 20040158045Abstract: A novel class or family of TGF-&bgr; binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.Type: ApplicationFiled: February 27, 2004Publication date: August 12, 2004Applicant: Darwin Discovery Ltd.Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
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Publication number: 20040115694Abstract: Methods and compounds, including compositions therefrom, are provided for determining the sequence of nucleic acid molecules. The methods permit the determination of multiple nucleic acid sequences simultaneously. The compounds are used as tags to generate tagged nucleic acid fragments which are complementary to a selected target nucleic acid molecule. Each tag is correlative with a particular nucleotide and, in a preferred embodiment, is detectable by mass spectrometry. Following separation of the tagged fragments by sequential length, the tags are cleaved from the tagged fragments. In a preferred embodiment, the tags are detected by mass spectrometry and the sequence of the nucleic acid molecule is determined therefrom. The individual steps of the methods can be used in automated format, e.g., by the incorporation into systems.Type: ApplicationFiled: July 16, 2003Publication date: June 17, 2004Applicant: QIAGEN Genomics, Inc.Inventors: Jeffrey Van Ness, John C. Tabone, J. Jeffry Howbert, John T. Mulligan
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Publication number: 20040058321Abstract: A novel class or family of TGF-&bgr; binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.Type: ApplicationFiled: March 7, 2002Publication date: March 25, 2004Applicant: Darwin Discovery Ltd.Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan Paeper, Jeffrey Van Ness, David G. Winkler
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Publication number: 20040009535Abstract: A novel class or family of TGF-&bgr; binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules. In particular, compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.Type: ApplicationFiled: June 16, 2003Publication date: January 15, 2004Applicant: Celltech R&D, Inc.Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler