Patents by Inventor John Tainer

John Tainer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) INHIBITORS AGAINST COVID MACRODOMAIN AND METHODS OF USING THE SAME
    Publication number: 20240109892
    Abstract: The present disclosure provides compounds of Formula (Ia) and Formula (Ib) and the pharmaceutically acceptable salts and solvates thereof, wherein A1, A2, R1, R2, R3, and R4 are defined as set forth in the specification. The present disclosure also provides the use of compounds of Formula (Ia) or Formula (Ib) to treat a coronavirus infection in a subject.
    Type: Application
    Filed: January 24, 2022
    Publication date: April 4, 2024
    Inventors: John A. TAINER, Zamal AHMED, Darin E. JONES, Davide MOIANI, Chris Arlen BROSEY
  • METHODS FOR TREATING CANCERS WITH INHIBITORS TARGETING THE ROLE OF GRB2 IN DNA REPAIR
    Publication number: 20230366033
    Abstract: Provided herein are methods for selecting and treating cancers that are homology-directed repair (HDR) proficient. As such, methods for sensitizing cancers to PARP inhibitor therapy and ionizing radiation are also provided. In some aspects, cancers are treated with a combination of a GRB2 inhibitor and a PARP inhibitor or a GRB2 inhibitor and ionizing radiation.
    Type: Application
    Filed: August 3, 2021
    Publication date: November 16, 2023
    Applicant: Board of Regents, The University of Texas System
    Inventors: John A. TAINER, Zamal AHMED, Zu YE
  • SMALL MOLECULE PARG INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20220202821
    Abstract: The present disclosure provides methods of inhibiting PARG in cancer cells, including methods comprising administering a PARG inhibitor that modulates position Tyr795 in PARG. Also provided herein are methods of treating and/or preventing cancer comprising administering a PARG inhibitor. In some embodiments, the PARG inhibitors are of the formula: wherein the variables are defined herein.
    Type: Application
    Filed: March 27, 2020
    Publication date: June 30, 2022
    Applicants: Board of Regents, The University of Texas System, Board of Trustees of The University of Arkansas, Washington University
    Inventors: John A. TAINER, Zamal AHMED, Darin E. JONES, In-Kwon KIM, Tom ELLENBERGER, Chris HO
  • SMALL MOLECULE GRB2 STABILIZERS FOR RAS MAP KINASE INHIBITION
    Publication number: 20220151991
    Abstract: The present disclosure compounds of the formula (I-A) or (I), wherein the variables are defined herein, as well as pharmaceutical compositions thereof. The present disclosure also provides methods for the use of said compounds and/or pharmaceutical compositions, such as in the treatment of cancer. The present disclosure also provides methods for the use of compounds of the formula (III), wherein the variables are defined herein.
    Type: Application
    Filed: March 13, 2020
    Publication date: May 19, 2022
    Applicants: Board of Regents, The University of Texas System, Board of Trustees of the University of Arkansas
    Inventors: Zamal AHMED, John A. TAINER, Darin E. JONES
  • DNA glycosylases and their use
    Patent number: 7662601
    Abstract: Novel cytosine-, thymine- and uracil-DNA glycosylases, subcellular localization peptides, nucleic acid molecules containing the same, methods of identifying such enzymes and their use in various methods including mutagenesis, cell killing and DNA sequencing and modification, are desired.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: February 16, 2010
    Inventors: Hans E. Krokan, Geir Slupphaug, Bodil Kavli, John A. Tainer, Clifford D. Mol
  • Novel DNA glycosylases and their use
    Publication number: 20060134631
    Abstract: Novel cytosine-, thymine- and uracil-DNA glycosylases, subcellular localization peptides, nucleic acid molecules containing the same, methods of identifying such enzymes and their use in various methods including mutagenesis, cell killing and DNA sequencing and modification, are desired.
    Type: Application
    Filed: December 23, 2003
    Publication date: June 22, 2006
    Inventors: Hans Krokan, Geir Slupphaug, Bodil Kavli, John Tainer, Clifford Mol
  • DNA glycosylases and their use
    Patent number: 6713294
    Abstract: Novel cytosine-, thymine- and uracil-DNA glycosylases, subcellular localization peptides, nucleic acid molecules containing the same, methods of identifying such enzymes and their use in various methods including mutagenesis, cell killing and DNA sequencing and modification, are described.
    Type: Grant
    Filed: March 3, 1999
    Date of Patent: March 30, 2004
    Inventors: Hans E. Krokan, Geir Slupphaug, Bodil Kavli, John A. Tainer, Clifford D. Mol
  • Metal binding proteins
    Patent number: 5665865
    Abstract: The invention describes a metal binding protein capable of forming a coordination complex with a metal cation. The protein contains a sequence of amino acid residues that defines a variable domain of an immunoglobulin light chain having a L1 region and a L3 region, and also contains three contact amino acid residues in the variable domain that participate as ligands for the metal coordination complex.
    Type: Grant
    Filed: November 22, 1994
    Date of Patent: September 9, 1997
    Assignee: The Scripps Research Institute
    Inventors: Richard A. Lerner, Victoria A. Roberts, Elizabeth D. Getzoff, John A. Tainer, Stephen J. Benkovic