Patents by Inventor John Thomas Bradshaw
John Thomas Bradshaw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230101709Abstract: A replacement fluid suitable to replace a target fluid, wherein the replacement fluid is different from the target fluid. The replacement fluid has pipetting characteristics substantially equivalent to the target fluid, wherein for a desired pipetted volume of the target fluid delivered by a pipette, a pipetted volume of the replacement fluid delivered by the pipette is substantially equivalent to the desired pipetted volume of the target fluid. The replacement fluid is a primary equivalent fluid having substantially similar pipetting characteristics. One or more additives may be added to the primary equivalent fluid. The one or more additives may include pipettability modifying additives and non pipettability modifying additives.Type: ApplicationFiled: February 5, 2022Publication date: March 30, 2023Inventors: John Thomas Bradshaw, Rachel Parshley, Heather Macken, Michael Grimaldi, Richard Curtis
-
Publication number: 20230102093Abstract: A replacement fluid suitable to replace a PCR Mastermix, wherein the replacement fluid is different from the PCR Mastermix. The replacement fluid has pipetting characteristics substantially equivalent to the PCR Mastermix, wherein for a desired pipetted volume of the target fluid delivered by a pipette, a pipetted volume of the replacement fluid delivered by the pipette is substantially equivalent to the desired pipetted volume of the PCR Mastermix. The replacement fluid is a primary equivalent fluid having substantially similar pipetting characteristics. One or more additives may be added to the primary equivalent fluid. The one or more additives may include pipettability modifying additives and non pipettability modifying additives.Type: ApplicationFiled: February 5, 2022Publication date: March 30, 2023Inventors: John Thomas Bradshaw, Rachel Parshley, Heather Macken, Michael Grimaldi, Richard Curtis
-
Patent number: 9234833Abstract: A system and related method for improved liquid delivery evaluation using a solution containing one or more dyes such that the solution exhibits multiple distinct detectable light absorbance spectral features for calibrating or testing over extended volume or dilution ranges are described. The system includes: a photometric instrument capable of measuring optical absorbance at multiple wavelengths; one or more sample solutions to be dispensed using the liquid delivery system whose performance is being tested or calibrated; and vessels optionally pre-filled, or filled by the user, with diluent solution. The sample solutions contain one or more dyes, chosen so that multiple distinct detectable light absorbance spectral features, such as peaks and/or valleys and/or plateaus of the solution can be distinguished for volume or dilution ranges of interest.Type: GrantFiled: March 18, 2013Date of Patent: January 12, 2016Assignee: Artel, Inc.Inventors: Richard H. Curtis, Ceara McNally, Charles A. Ewing, John Thomas Bradshaw
-
Patent number: 8692987Abstract: An apparatus used to calibrate microtiter plate readers. The apparatus includes one or more structures having two exterior surfaces wherein one of the exterior surfaces is coated with a coating selected to establish on that surface a reflection loss that mimics reflection loss at an air-liquid interface, and the other of the two exterior surfaces is coated with a coating selected to establish a reflection loss on that surface that mimics the reflection loss at a bottom surface of a microtiter plate. The apparatus may be a single layer, a multi-layered composition or a container. The apparatus is an artifact that may be used to calibrate a plate reader by mimicking a solution-filled microtiter plate. The artifact may be used for a plurality of liquids, including water. The artifact produces reflection losses more closely mirroring reflection losses expected for a liquid-filled microtiter plate well.Type: GrantFiled: August 9, 2011Date of Patent: April 8, 2014Assignee: Artel, Inc.Inventors: Richard H. Curtis, John Thomas Bradshaw
-
Patent number: 8404158Abstract: A system and related method for improved liquid delivery evaluation using a solution containing one or more dyes such that the solution exhibits multiple distinct detectable light absorbance spectral features for calibrating or testing over extended volume or dilution ranges are described. The system includes: a photometric instrument capable of measuring optical absorbance at multiple wavelengths; one or more sample solutions to be dispensed using the liquid delivery system whose performance is being tested or calibrated; and vessels optionally pre-filled, or filled by the user, with diluent solution. The sample solutions contain one or more dyes, chosen so that multiple distinct detectable light absorbance spectral features, such as peaks and/or valleys and/or plateaus of the solution can be distinguished for volume or dilution ranges of interest.Type: GrantFiled: April 7, 2008Date of Patent: March 26, 2013Assignee: Artel, Inc.Inventors: Richard H. Curtis, Ceara McNally, Charles A. Ewing, John Thomas Bradshaw
-
Publication number: 20130038873Abstract: An apparatus used to calibrate microtiter plate readers. The apparatus includes one or more structures having two exterior surfaces wherein one of the exterior surfaces is coated with a coating selected to establish on that surface a reflection loss that mimics reflection loss at an air-liquid interface, and the other of the two exterior surfaces is coated with a coating selected to establish a reflection loss on that surface that mimics the reflection loss at a bottom surface of a microtiter plate. The apparatus may be a single layer, a multi-layered composition or a container. The apparatus is an artifact that may be used to calibrate a plate reader by mimicking a solution-filled microtiter plate. The artifact may be used for a plurality of liquids, including water. The artifact produces reflection losses more closely mirroring reflection losses expected for a liquid-filled microtiter plate well.Type: ApplicationFiled: August 9, 2011Publication date: February 14, 2013Applicant: ARTEL, INC.Inventors: Richard H. Curtis, John Thomas Bradshaw
-
Patent number: 8003405Abstract: A method for determining the volume of a test liquid aliquot used to calibrate a liquid delivery device. The method is useful for determining the volume of an aliquot of a test liquid which is complex, non-aqueous or both. A mixture contains the test liquid and a stock solution including a first dye, the first dye having absorbance characteristics which are measurably distinguishable from the absorbance characteristics of a second dye. The mixture is mixed with a diluent including the second dye to form a sample solution used to measure absorbances of the first dye and the second dye. The test liquid and the stock solution are combined gravimetrically in a controlled ratio so that the flow characteristics of the test-stock mixture correspond to the flow characteristics of the test liquid and without affecting the ability to distinguish the absorbance characteristics between the first dye and the second dye.Type: GrantFiled: December 16, 2005Date of Patent: August 23, 2011Assignee: Artel, Inc.Inventors: Keith J. Albert, John Thomas Bradshaw, Alex L. Rogers
-
Patent number: 7998747Abstract: The invention provides ways to determine the impact of diluting a solution wherein the diluting may be carried out for any of a variety of purposes. In one embodiment, the method enables accurate volume dispensation calculations independent of meniscus shape. In another embodiment, the method enables accurate determination of plate washing efficiency. In yet another embodiment, the method enables the accurate determination of dilution ratio over a plurality of dilution steps. The methods described may be carried out using one or more systems arranged to perform the steps. A kit of the invention includes instructions for carrying out the steps of the methods and, optionally, one or more solutions suitable for conducting photometric measurements.Type: GrantFiled: September 13, 2007Date of Patent: August 16, 2011Assignee: Artel, Inc.Inventors: John Thomas Bradshaw, Richard H. Curtis, Keith J. Albert, Tanya R. Knaide, Ceara McNally, Alex L. Rogers
-
Patent number: 7919327Abstract: The invention provides ways to determine the impact of diluting a solution wherein the diluting may be carried out for any of a variety of purposes. In one embodiment, the method enables accurate volume dispensation calculations independent of meniscus shape. In another embodiment, the method enables accurate determination of plate washing efficiency. In yet another embodiment, the method enables the accurate determination of dilution ratio over a plurality of dilution steps. The methods described may be carried out using one or more systems arranged to perform the steps. A kit of the invention includes instructions for carrying out the steps of the methods and, optionally, one or more solutions suitable for conducting photometric measurements.Type: GrantFiled: July 26, 2010Date of Patent: April 5, 2011Assignee: Artel, Inc.Inventors: John Thomas Bradshaw, Richard H. Curtis, Keith J. Albert, Tanya R. Knaide, Ceara McNally, Alex L. Rogers
-
Publication number: 20100290048Abstract: The invention provides ways to determine the impact of diluting a solution wherein the diluting may be carried out for any of a variety of purposes. In one embodiment, the method enables accurate volume dispensation calculations independent of meniscus shape. In another embodiment, the method enables accurate determination of plate washing efficiency. In yet another embodiment, the method enables the accurate determination of dilution ratio over a plurality of dilution steps. The methods described may be carried out using one or more systems arranged to perform the steps. A kit of the invention includes instructions for carrying out the steps of the methods and, optionally, one or more solutions suitable for conducting photometric measurements.Type: ApplicationFiled: July 26, 2010Publication date: November 18, 2010Applicant: ARTEL, INC.Inventors: John Thomas Bradshaw, Richard H. Curtis, Keith J. Albert, Tanya R. Knaide, Ceara McNally, Alex L. Rogers
-
Patent number: 7791716Abstract: A system and related method for improved liquid delivery evaluation using a solution containing one or more dyes such that the solution exhibits multiple distinct detectable light absorbance spectral features for calibrating or testing over extended volume or dilution ranges are described. The system includes: a photometric instrument capable of measuring optical absorbance at multiple wavelengths; one or more sample solutions to be dispensed using the liquid delivery system whose performance is being tested or calibrated; and vessels optionally pre-filled, or filled by the user, with diluent solution. The sample solutions contain one or more dyes, chosen so that multiple distinct detectable light absorbance spectral features, such as peaks and/or valleys and/or plateaus of the solution can be distinguished for volume or dilution ranges of interest.Type: GrantFiled: April 7, 2008Date of Patent: September 7, 2010Assignee: Artel, Inc.Inventors: Ceara McNally, John Thomas Bradshaw, Richard H. Curtis, Charles A. Ewing, Keith J. Albert, Tanya R. Knaide, Alexis L. Rogers
-
Publication number: 20090250664Abstract: A system and related method for improved liquid delivery evaluation using a solution containing one or more dyes such that the solution exhibits multiple distinct detectable light absorbance spectral features for calibrating or testing over extended volume or dilution ranges are described. The system includes: a photometric instrument capable of measuring optical absorbance at multiple wavelengths; one or more sample solutions to be dispensed using the liquid delivery system whose performance is being tested or calibrated; and vessels optionally pre-filled, or filled by the user, with diluent solution. The sample solutions contain one or more dyes, chosen so that multiple distinct detectable light absorbance spectral features, such as peaks and/or valleys and/or plateaus of the solution can be distinguished for volume or dilution ranges of interest.Type: ApplicationFiled: April 7, 2008Publication date: October 8, 2009Applicant: Artel, Inc.Inventors: Richard H. Curtis, Ceara McNally, Charles A. Ewing, John Thomas Bradshaw
-
Publication number: 20090251681Abstract: A system and related method for improved liquid delivery evaluation using a solution containing one or more dyes such that the solution exhibits multiple distinct detectable light absorbance spectral features for calibrating or testing over extended volume or dilution ranges are described. The system includes: a photometric instrument capable of measuring optical absorbance at multiple wavelengths; one or more sample solutions to be dispensed using the liquid delivery system whose performance is being tested or calibrated; and vessels optionally pre-filled, or filled by the user, with diluent solution. The sample solutions contain one or more dyes, chosen so that multiple distinct detectable light absorbance spectral features, such as peaks and/or valleys and/or plateaus of the solution can be distinguished for volume or dilution ranges of interest.Type: ApplicationFiled: April 7, 2008Publication date: October 8, 2009Applicant: Artel, Inc.Inventors: Ceara J. McNally, John Thomas Bradshaw, Richard H. Curtis, Charles A. Ewing, Keith J. Albert, Tanya R. Knaide, Alexis L. Rogers
-
Patent number: 7061608Abstract: An apparatus and related method for optical calibration of spectrophotometers is described. The apparatus is a calibration plate including one or more cuvettes filled with solutions of interest. The cuvettes are sealed to prevent evaporation. The cuvettes also possess a compressible component to allow for expansion of the solution and a bubble control apparatus to ensure that the compressible component does not intersect the beam path. A piece of neutral density glass is optionally included in the apparatus to track optical changes of the solutions over time.Type: GrantFiled: January 30, 2004Date of Patent: June 13, 2006Assignee: Artel, Inc.Inventors: John Thomas Bradshaw, Richard H. Curtis