Patents by Inventor John Thornback

John Thornback has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immobilized labeling compounds and methods
    Patent number: 7320784
    Abstract: The invention includes methods and compounds for labelling conjugates with metals which comprise the steps of coupling the conjugate to a support surface; introducing a complex-forming metal to the support; and collecting the metal-conjugate complex released from the support. The metal catalyzes cleavage of the conjugate from the support upon complex formation resulting in a solutions substantially free of unlabeled conjugate.
    Type: Grant
    Filed: August 3, 1999
    Date of Patent: January 22, 2008
    Assignee: Bracco Imaging S.p.A.
    Inventors: Alfred Pollak, David Roe, Linda Fung Lu, John Thornback, Catherine M. Pollock
  • Angiogenesis targeting molecules
    Publication number: 20030194373
    Abstract: The present invention relates to compounds that are effective for targeting sites of angiogenesis for diagnostic and therapeutic purposes. The compounds are of the Formula (I) A-(B)n-C, wherein A is a chelator moiety capable of complexing a radionuclide metal or a moiety capable of binding to a halogen; B is a spacer group; C is an angiogenesis targeting molecule; and n is selected from the integers 0 and 1. The invention also relates to a method of imaging sites of angiogenesis and treating patients through the administration of the compounds of the present invention.
    Type: Application
    Filed: April 22, 2003
    Publication date: October 16, 2003
    Inventors: Theresa Fauconnier, Alfred Pollak, John Thornback, Dennis Eshima
  • Non-receptor cell mediated imaging agents
    Patent number: 5837218
    Abstract: Detectably labelled non-receptor mediated cell-associating compounds are provided for use in the diagnostic imaging of target sites in a mammal. Cell-associating compounds may be directly labelled, or labelled via a chelating compound to form a conjugate. Such cell-associating compounds are particularly useful to image target sites such as tumour sites and sites of infection.
    Type: Grant
    Filed: August 22, 1996
    Date of Patent: November 17, 1998
    Assignee: Resolution Pharmaceuticals Inc.
    Inventors: Susan H. Peers, Anne Goodbody, Alfred Pollak, John Thornback
  • Radiolabeled D4 receptor ligands
    Patent number: 5725838
    Abstract: Herein described are radiolabeled compounds and their precursors useful to image D4 receptors in vivo, of the formula: ##STR1## wherein R is selected from iodo, tri(loweralkyl)tin and a radioisotopically labeled iodide and R.sup.1 is selected from H and alkoxycarbonyl, with the proviso that R is not iodo when R.sup.1 is H.The radiopharmaceutical compounds are useful particularly to image localization of D4 receptor in the human brain, and can therefore aid in the diagnosis of schizophrenia and other medical conditions in which the D4 receptor is implicated.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: March 10, 1998
    Assignee: Resolution Pharmaceuticals, Inc.
    Inventors: Alfred Pollak, Robert Dunn-Dufault, John Thornback
  • Non-receptor mediated imaging agents
    Patent number: 5688489
    Abstract: Detectably labelled non-receptor mediated cell-associating compounds are provided for use in the diagnostic imaging of target sites in a mammal. Cell-associating compounds may be directly labelled, or labelled via a chelating compound to form a conjugate. Such cell-associating compounds are particularly useful to image target sites such as tumour sites and sites of infection.
    Type: Grant
    Filed: September 15, 1995
    Date of Patent: November 18, 1997
    Assignee: Resolution Pharmaceuticals, Inc.
    Inventors: Susan H. Peers, Anne Goodbody, Alfred Pollak, John Thornback