Patents by Inventor John Timothy Lonsdale

John Timothy Lonsdale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polynucleotide encoding the enoyl-acyl carrier protein reductase of , FAB I
    Patent number: 6995254
    Abstract: Prokayrotic FAB I polypeptides and DNA (RNA) encoding such FAB I and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FAB I for the treatment of infection, such as bacterial infections. Antagonists against such FAB I and their use as a therapeutic to treat infections, such as staphylococcal infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FAB I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding FAB I and for detecting the polypeptide in a host.
    Type: Grant
    Filed: January 28, 1997
    Date of Patent: February 7, 2006
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: David John Payne, Peter Henry Milner, Stewart Campbell Pearson, John Timothy Lonsdale
  • FabI
    Patent number: 6753172
    Abstract: Prokayrotic FABI polypeptides and DNA (RNA) encoding such FABI and a procedure for such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FABI for the treatment of infection, such as bacterial infections. Antagonists against such FABI and their use as a therapeutic to treat infections, such asstaphylococcal infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FABI nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding FABI and for detecting the polypeptide in a host.
    Type: Grant
    Filed: April 15, 1999
    Date of Patent: June 22, 2004
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: David John Payne, Peter Henry Milner, Stewart Campbell Pearson, John Timothy Lonsdale
  • Methods of modulating FabH activity
    Publication number: 20040087506
    Abstract: The invention provides FabH polypeptides and polynucleotides encoding FabH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabH polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: September 23, 2003
    Publication date: May 6, 2004
    Applicants: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Alexaxndros K. Konstantinidis, John Timothy Lonsdale, Glen Scott Van Aller
  • Methods of modulating FabH activity
    Publication number: 20030186435
    Abstract: The invention provides FabH polypeptides and polynucleotides encoding FabH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabH polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: May 22, 2003
    Publication date: October 2, 2003
    Applicants: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Alexandros K. Konstantinidis, John Timothy Lonsdale, Glenn Scott Van Aller
  • Polynucleotides encoding staphylcoccal FAB I enoyl-ACP reductase
    Patent number: 6432670
    Abstract: Prokayrotic FAB I polypeptides and DNA (RNA) encoding such FAB I and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FAB I for the treatment of infection, such as bacterial infections. Antagonists against such FAB I and their use as a therapeutic to treat infections, such asstaphylococcal infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FAB I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding FAB I and for detecting the polypeptide in a host.
    Type: Grant
    Filed: April 15, 1999
    Date of Patent: August 13, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: David John Payne, Peter Henry Milner, Stewart Campbell Pearson, John Timothy Lonsdale
  • FabD
    Patent number: 6258934
    Abstract: FabD polypeptides and DNA (RNA) encoding such FabD and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FabD for the treatment of infection, particularly bacterial infections. Antagonists against such FabD and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FabD nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Fab (Fatty acid biosynthesis) and for detecting the polypeptide in a host.
    Type: Grant
    Filed: July 1, 1998
    Date of Patent: July 10, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Daniel Robert Gentry, David John Payne, Stewart Campbell Pearson, John Timothy Lonsdale
  • FabH
    Patent number: 5885572
    Abstract: The invention provides FabH polypeptides and DNA (RNA) encoding such FabH and a procedure for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such FabH for the treatment of infection, particularly bacterial infections. Antagonists against such FabH and their use as a therapeutic to treat infections, particularly bacterial infections are also provided. Further provided are diagnostic assays for detecting diseases related to the presence of FabH nucleic acid sequences and the polypeptides in a host. Also provided are diagnostic assays for detecting polynucleotides encoding novel Fab family proteins and for detecting such polypeptides in a host.
    Type: Grant
    Filed: August 25, 1997
    Date of Patent: March 23, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Daniel Robert Gentry, John Timothy Lonsdale, David John Payne, Stewart Campbell Pearson
  • FabD polynucleotides
    Patent number: 5827689
    Abstract: FabD polypeptides and DNA (RNA) encoding such FabD and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FabD for the treatment of infection, particularly bacterial infections. Antagonists against such FabD and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FabD nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Fab (Fatty acid biosynthesis) and for detecting the polypeptide in a host.
    Type: Grant
    Filed: January 24, 1997
    Date of Patent: October 27, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Daniel Robert Gentry, David John Payne, Stewart Campbell Pearson, John Timothy Lonsdale
  • FabH
    Patent number: 5783432
    Abstract: The invention provides FabH polypeptides and DNA (RNA) encoding such FabH and a procedure for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such FabH for the treatment of infection, particularly bacterial infections. Antagonists against such FabH and their use as a therapeutic to treat infections, particularly bacterial infections are also provided. Further provided are diagnostic assays for detecting diseases related to the presence of FabH nucleic acid sequences and the polypeptides in a host. Also provided are diagnostic assays for detecting polynucleotides encoding novel Fab family proteins and for detecting such polypeptides in a host.
    Type: Grant
    Filed: August 25, 1997
    Date of Patent: July 21, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Daniel Robert Gentry, John Timothy Lonsdale, David John Payne, Stewart Campbell Pearson
  • FabH
    Patent number: 5759832
    Abstract: The invention provides FabH polypeptides and DNA (RNA) encoding such FabH and a procedure for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such FabH for the treatment of infection, particularly bacterial infections. Antagonists against such FabH and their use as a therapeutic to treat infections, particularly bacterial infections are also provided. Further provided are diagnostic assays for detecting diseases related to the presence of FabH nucleic acid sequences and the polypeptides in a host. Also provided are diagnostic assays for detecting polynucleotides encoding novel Fab family proteins and for detecting such polypeptides in a host.
    Type: Grant
    Filed: November 18, 1996
    Date of Patent: June 2, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Daniel Robert Gentry, John Timothy Lonsdale, David John Payne, Stewart Campbell Pearson