Patents by Inventor John Timothy Sheehan

John Timothy Sheehan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid phase synthesis of peptides
    Patent number: 4028315
    Abstract: A process for bonding an amino acid to an insoluble hydroxymethyl polymer by esterifying the C-terminal carboxyl group of an N-terminal protected amino acid with the hydroxyl group of an insoluble hydroxymethyl polymer. The esterifying takes place at about room temperature in the presence of a condensing agent. The insoluble hydroxymethyl polymer is a hydroxymethylated copolymer of styrene and divinylbenzene, hydroxymethylcellulose, hydroxymethylated sulfonated polystyrene or polyvinyl alcohol. The condensing agent is dicyclohexylcarbodiimide, carbonyldiimidazole, thionyl chloride, phosphorous oxychloride or ethoxyacetylene. Peptides can be formed by bonding one or more amino acids to the amino acid bonded to the insoluble hydroxymethyl polymer.
    Type: Grant
    Filed: February 20, 1973
    Date of Patent: June 7, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miklos Bodanszky, John Timothy Sheehan