Abstract: The subject invention pertains to compositions comprising an opioid receptor antagonist and an opioid receptor agonist and methods of inhibiting an opioid overdose in a subject. The opioid receptor antagonist can be naloxone or a derivative thereof, while the opioid receptor agonist can be nalbuphine or a derivative thereof. The composition can be administered intranasally, intravenously and by autoinjector. The reversal time can be about three minutes.

Abstract: A system is configured to bring about anastomosis between two lumens in a patient or between two sections of a single lumen in a patient. The anastomosis system includes a first tissue-compressing element, a second tissue-compressing element, and an energy source. The energy source can be a thermal energy source or laser energy source. Tissue is interposed between the elements. Magnetic material incorporated into the tissue-compressing elements facilitates the alignment of the elements as well as compression of the interposed tissue. The energy source can deliver energy to tissue. This delivery of energy can cause local changes to the tissue that can help maintain positional stability of the implants, can bring about immediate patency of the anastomosis and can otherwise facilitate achieving desired outcomes for the patient.

Abstract: Methods of production of edible filamentous fungal biomat formulations are provided as standalone protein sources and/or protein ingredients in foodstuffs as well as a one-time use or repeated use self-contained biomat reactor comprising a container with at least one compartment and placed within the compartment(s), a feedstock, a fungal inoculum, a gas-permeable membrane, and optionally a liquid nutrient medium.

Abstract: An orthopedic implant with an inferior portion having a tibia contact surface configured to extend over a tibia; a superior portion opposite to the inferior portion having a tendon contact surface configured to change a position of a patellar tendon by lifting or tilting the patellar tendon when the curved surface of the first portion is engaged with the tibia; and a fixation mechanism adapted to attach the orthopedic implant to the tibia, the orthopedic implant being further configured to change shape from a first configuration to a second configuration in response to a load applied between the tendon contact surface and the tibia contact surface. The invention also addresses corresponding methods.

Abstract: A device to test the seal quality of an earpiece. Audio processing circuitry produces an audio signal for driving a speaker. Output from the microphone while the speaker is being driven by the audio signal is used to determine the seal. The device or method further includes control circuitry to evaluate a seal quality of the device. Other embodiments are disclosed.

Abstract: Disclosed herein is a system for delivering a nitric oxide to a subject, wherein the system comprises: (a) a nitric oxide injection line configured to inject a first gas at an injection point into a breathing conduit comprising a breathing gas, wherein the first gas comprises a first amount of nitric oxide; (b) a sampling line configured to sample a second gas comprising a second amount of nitric oxide and the breathing gas at a sampling location between the injection point of the first gas and a subject and (c) a feedback-loop controller that is in communication with: (i) a nitric oxide set-point controller configured to set a nitric oxide set-point amount; (ii) a source configured to provide a third gas having a third amount of nitric oxide; and (iii) at least one sensor configured to measure the second amount of nitric oxide in the sampling line.

Abstract: An optical sensing module suitable for wearable devices, the optical sensing module comprising: a silicon or silicon nitride transmitter photonic integrated circuit (PIC), the transmitter PIC comprising: a plurality of lasers, each laser of the plurality of lasers operating at a wavelength that is different from the wavelength of the others; an optical manipulation region, the optical manipulation region comprising one or more of: an optical modulator, optical multiplexer (MUX); and additional optical manipulation elements; and one or more optical outputs for light originating from the plurality of lasers.

Abstract: A system for gait training is disclosed. The system includes a frame having a first, second, third and fourth leg. A pivoting bar is rotatably coupled to an upper portion of the frame and configured to rotate independent of the frame. A plurality of flexible support members are connected to the frame, the plurality of flexible support members including at least one upright flexible support member connected to the pivoting bar and at least one lateral flexible support member connected to at least one of the first, second, third and fourth legs.

Abstract: An occlusion device includes a balloon and a catheter. The occlusion device is configured to allow blood to pass through the balloon, instead of around the balloon. By allowing the blood to pass through the balloon, constant traction against the vessel wall is achieved, regardless of flow rate, thereby mitigating distal migration. The balloon includes an orifice to allow blood flow through the balloon. The orifice is independent of the diameter of the vessel, therefore the effect of the diameter of the vessel changing during the procedure will not affect the flow rate of blood. The occlusion device enables finer titration of blood flow by varying the size of the orifice when compared to conventional solutions.

Abstract: A wearable health management system includes a flexible member configured to be worn on an affected area by a patient. At least one actuator is operably coupled to the flexible member. The at least one actuator is configured to be adjusted between a deployed state and a non-deployed state. At least one of a photoplethysmogram sensor and a bioimpedance sensor is coupled to the flexible member to obtain one or more health metrics from the patient. A controller is in communication with the at least one actuator. The controller is configured to adjust the at least one actuator to the deployed state to provide a selected pressure to the affected area.

Abstract: A dispensing system for a floor treatment composition. The dispensing system includes a housing partially enclosing a cavity and a cradle moveable within the housing along a z-axis from a first position to a second position. The dispensing system further includes a chassis and a sliding lock that includes an open frame. An inlet canula projects through the open frame. When the cradle is in the second position, the inlet canula entrance projects through the open frame and through a liquid transport aperture in the cradle. Latches extending from the open frame also project through engagement apertures in the cradle when the cradle is in the second position. The dispensing system further includes a pump in fluid communication with the inlet canula and a mop head in fluid communication with the pump.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: An implantable device for detecting biomarkers in animals, the device comprises: a sensor comprising: a pair of electrodes spaced apart from each other, the pair of electrodes having a first capacitance; an oscillator configured to oscillate at a first frequency and output a first signal at the first frequency; wherein the sensor is configured to receive an amount of biological fluid wherein the biological fluid causes the capacitance of the pair of electrodes to change from the first capacitance to a second capacitance; wherein the oscillator is coupled to the pair of electrodes and arranged such that a change in the capacitance of the pair of electrodes causes a change in oscillation of the oscillator from the first frequency to a second frequency; and wherein the oscillator is configured to output a second signal at the second frequency, the second signal indicative of a biomarker in the biological fluid.

Abstract: The present invention relates to a method of chemovaccination against Plasmodium infection comprising administering to a patient an effective amount of a selective inhibitor of plasmepsin X, or a pharmaceutically acceptable salt thereof.

Abstract: A surgical navigation method utilizing a computer system. The method includes the steps of: (a) fixing a camera relative to a surgical site on a patient such that the camera does not move relative to the surgical site; (b) restraining the body portion of the patient which includes the surgical site relative to an operating table supporting the patient, such that the body portion does not move relative to the operating table; and (c) detecting with the camera the position of a medical instrument having a tracker array.

Abstract: The present disclosure relates generally to pharmaceutical compositions comprising cannabidiol (CBD), ?-9-tetrahydrocannabinol (THC) and linalool. In some embodiments, the pharmaceutical compositions are useful in the treatment of an inflammatory condition, e.g., useful for the treatment of pain.

Abstract: An adapter for removably coupling a tracker to a surgical handpiece includes a proximal member having an interface configured to engage and prevent rotation of the proximal member relative to the surgical handpiece, a distal member slidably and rotatably coupled to the proximal member, a biasing member disposed between the proximal distal members and configured to urge the proximal and distal members in opposing directions, and a tracking array mount coupled to the distal member. The biasing member is configured to be compressed by a reference feature of the end effector and the surgical handpiece when the distal member is disposed on the end effector and the end effector is coupled to the surgical handpiece, the compressed biasing member creating a frictional force between the distal and proximal members that resists rotation of the distal member relative to the proximal member.

Abstract: Disclosed herein are methods for otoprotection against platinum-based antineoplastic agents by administering a thiosulfate salt to a subject in need thereof. Typically, the thiosulfate salt is administered to the subject scheduled to be administered a platinum-based antineoplastic agent within 4 hours. Alternatively, the thiosulfate salt is administered within 7 hours after the administration of a platinum-based neoplastic agent.

Abstract: This disclosure relates to macro- and micro-sized elastin-like polymers (ELP). The addition of a polyethyleneimine (PEI) block to the terminal end of ELP allows the particle radius as well as LCST to be controlled by changing any combination of polymer concentration, ion concentration, and pH. The addition of the PEI block also provides the ability to crosslink the copolymers and achieve a stable particle radius.

Abstract: Disclosed herein is a YNU-5 zeolite and/or a phosphorus modified YNU-5 zeolite, methods of their preparation, and methods of their use in hydrocarbon conversion processes, e.g., as part of a catalyst component and/or as part of a catalyst composition. Catalyst components with YNU-5 zeolite and/or with phosphorus modified YNU-5 zeolites, their methods of preparation, and their methods of use suitable for petroleum refining applications (e.g., hydrocarbon conversion processes such as fluid catalytic cracking and hydrocracking) are described herein. Also disclosed herein are catalyst compositions, which include YNU-5 zeolites and/or phosphorus modified YNU-5 zeolites and catalyst components thereof along with at least one additional catalyst component.