Abstract: The present invention is directed to novel heterodimeric antibodies.

Abstract: Methods and systems are described that are utilized for remotely controlling a musical instrument. A first digital record comprising musical instrument digital commands from a first electronic instrument for a first item of music is accessed. The first digital record is transmitted over a network using a network interface to a remote, second electronic instrument for playback to a first user. Optionally, video data is streamed to a display device of a user while the first digital record is played back by the second electronic instrument. A key change command is transmitted over the network using the network interface to the second electronic instrument to cause the second electronic instrument to playback the first digital record for the first item of music in accordance with the key change command. The key change command may be transmitted during the streaming of the video data.

Abstract: A series of cells for use in an electrochemical device, such as an electrochemical cell or battery, that can operate in a single bulk electrolyte solution shared among the cells. Methods of producing hydrogen or both hydrogen and electricity in appreciable quantifies and in various ratios, and vehicles or other devices and applications powered by electrochemical devices comprising the series.

Abstract: A system for stimulating tissue generally comprises a resorbable implant. The resorbable implant includes a substrate, at least one contact, and a transceiver, wherein the substrate, the at least one contact, and the transceiver are resorbable. The system also includes a controller configured to communicate with the transceiver of the resorbable implant and a power supply connected to the controller. The controller delivers power to the resorbable implant from the power supply. The resorbable implant delivers electrical stimulation to tissue when the resorbable implant receives power.

Abstract: Methods, compositions and devices for single molecule sequencing are provided, particularly for solid-state synthesis and processing of expandable polymers (e.g., Xpandomers), as well as methods and compositions for producing new expandable polymer constructs that provide more accurate sequence information when passed through a nanopore sensor.

Abstract: A flow control manifold apparatus includes a housing defining a first flow path from a flow input port to flow output port and a second flow path from a return inlet port to a return outlet port. A first flow regulating valve is placed inline the first flow path and an excess flow path fluidly couples the first flow path to the second flow path. An excess pressure valve is placed inline the excess flow path and is in a closed orientation when the first flow regulating valve is open so that all of the fluid exits through the flow output port. The excess pressure valve is then in a partially open orientation when the first flow regulating valve is partially closed so that a first portion of the fluid exits through the flow output port and a second portion of the fluid exits through the return outlet port.

Abstract: Aspects of the subject disclosure may include, for example, obtaining a model of a communication network, applying first data to the model to generate an updated model, processing the updated model to establish a first control, enabling first communications in the communication network in accordance with the first control, obtaining first parametric data regarding the first communications in the communication network that are based on the first control, processing the first parametric data in accordance with the updated model to generate an updated first control, and enabling second communications in the communication network in accordance with the updated first control. Other embodiments are disclosed.

Abstract: The present invention is directed to methods for filling a container wherein the filled container has no headspace. The present invention is further directed to methods for stabilizing an aqueous drug substance solution by filling a container with the aqueous drug substance solution wherein the filled container has no headspace. The present invention is further directed to methods for detecting headspace in a container.

Abstract: Disclosed biopsy markers are adapted to serve as localization markers during a surgical procedure. Adaptation includes incorporation of materials detectable under ultrasound during surgery, as well as features for co-registration with image guidance or other real-time imaging technologies during surgery. Such biopsy markers, when used as localization markers, improve patient comfort and reduce challenges in surgical coordination and surgery time. Additional disclosed biopsy markers are adapted to serve as monitoring and/or detection apparatuses. Localization of an implanted marker may be done with ultrasound technology. Ultrasound image data is analyzed to identify the implanted marker. A distance to the marker or a lesion may be determined and displayed. The determined distance may be a distance between the ultrasound probe and the marker or lesion, a distance between the marker or lesion and an incision instrument, and/or a distance between the ultrasound probe and the incision instrument.

Abstract: The present application discloses systems, methods, and computer-readable media that utilize computing devices to model multi-outcome transportation-value metrics that account for spatio-temporal trajectories across locations, times and other contextual features, and then utilize computer networks to dispatch provider devices to locations based on the multi-outcome transportation-value metrics. Moreover, the disclosed systems can utilize these multi-outcome transportation-value metrics and/or other models to manage and utilize dynamic transportation dispatch modes to more efficiently align provider devices and requestor devices across computer networks. For instance, the disclosed system can dispatch a provider device based on a discounted multi-outcome transportation-value metric.

Abstract: A jig for assembling a cabinet is disclosed. The jig includes a clamp assembly pivotally attached to a base. The clamp assembly includes a first jaw and a second jaw configured to apply a clamping force therebetween. The clamp assembly can pivot between a first position and a first inclined position. In the first position, a front support plate of the clamp assembly is oriented vertically, and in the first inclined position, a first angle less than 90 degrees is formed between the front support plate and a support surface on which the base rests. The clamp assembly may also pivot to a second inclined position at which a second angle less than the first angle is formed between the front support plate and the support surface.

Abstract: The present disclosure is directed to a method of operating a combustion system to attenuate combustion dynamics. The method includes flowing, via a compressor section, an overall supply of air to the combustion system; flowing, via a fuel supply system, an overall flow of fuel to the combustion system; flowing, to a first fuel nozzle of the combustion system, a first supply of fuel defining a richer burning fuel-air mixture at the first fuel nozzle; flowing, to a second fuel nozzle of the combustion system, a second supply of fuel defining a leaner burning fuel-air mixture at the second fuel nozzle; and igniting the richer burning fuel-air mixture and the leaner burning fuel-air mixture to produce an overall fuel-air ratio at a combustion chamber of the combustion system.

Abstract: Diabetes management systems include an insulin delivery device and a monitoring device for detecting at least one characteristic relating to the insulin delivery device. Monitoring devices may comprise pen caps.

Abstract: Methods for preparing oriented polymer tubes, such as biodegradable polymer tubes suitable for in vivo use, are provided herein. The disclosed methods provide alternatives to the typical extrusion/expansion methods by which oriented polymeric tubes for such uses are commonly produced. Advantageously, the disclosed methods can provide more homogeneous molecular orientation of crystallizable polymers within the tube walls, which can endow such polymeric tubes with enhanced strength (e.g., resistance to compression) and toughness.

Abstract: An apparatus for humidifying a flow of pressurised, breathable air includes varying a first pressure of the flow of breathable gas to vary a level of thermal engagement between the conductive portion of the reservoir and the heater plate, varying a height of the variable portion varies a level of thermal engagement between the conductive portion of the reservoir and the heater plate, use of a humidifier reservoir base component with a maximum water capacity substantially equal to the predetermined maximum volume of water of the humidifier reservoir or the use of intersecting inlet and outlet axes.

Abstract: A method is disclosed for doping a quantity of powder particles. A container having a central chamber is initially charged with a quantity of powder particles. A quantity of precursor is sublimed to form a heated precursor. A quantity of carrier gas is mixed with the precursor to form a mixture of heated precursor/carrier gas. The central chamber is charged with the heated precursor/carrier gas and then moved to cause interaction of the powder particles with the heated precursor/carrier gas to form a first monolayer coating on the powder particles. The heated precursor/carrier gas is then removed from the central chamber and the central chamber is charged with a O2/O3 gas under a plasma. The central chamber is then further moved to produce interaction of the O2/O3 gas with the first monolayer coating on the powder particles to modify the first monolayer coating to create a different, single monolayer coating forming an oxide coating on the powder particles.

Abstract: An electrode for a plasma reactor, the electrode comprising an elongate body having an inlet end and an opposed outlet end, a reaction region extending along a portion of the elongate body, a first sealing region located between the reaction region and the inlet end of the elongate body and a second sealing region located between the reaction region and the outlet end of the elongate body, wherein the first sealing region and the second sealing region each comprise a plurality of receiving portions adapted to receive a sealing member therein, and wherein a barrier member adapted to reduce or eliminate the flow of fluid between the receiving portions provided between each of the plurality of receiving portions.

Abstract: The present disclosure provides methods of treating cancer in a patient determined to have a HER2 mutation, such as an insertion mutation, by administering a third-generation tyrosine kinase inhibitor, such as poziotinib, in combination with a HER2 anti-body-drug conjugate.

Abstract: A park lock for an output drive gear includes a pawl, a rotational cam, and a rotational spring. The pawl has an engagement protrusion that extends outward from a body disposed on a pawl rotational shaft, such that rotation moves the engagement protrusion toward the output drive gear. The rotational cam rotates such that a circumferential side engages with a portion of the pawl opposite the engagement protrusion, causing rotation of the pawl about the rotational pawl shaft to move the engagement protrusion towards the output drive gear. The rotational spring maintains tension on the pawl and cam such that the engagement protrusion maintains an engagement with the output drive gear based on rotation of the cam and a speed of the output drive gear.

Abstract: A sand trap rake for use on golf courses includes an elongate rake head having an elongate body member with a front end, a back end, and first and second lateral sides between the front and back ends. The rake head defines a raking direction aligned with a direction extending from the front end to the back end. A plurality of tines extend downwardly from the body member and are spaced apart along a longitudinal direction of the rake head, transverse to the raking direction. The rake further includes an elongate front blade extending downwardly from the front end of the body member, and an elongate rear blade extending downwardly from the back end of the body member. The rake may be used in one of four selectable raking modes to prepare a sand surface for golf play.